Ornidazole

Description overdue on 20.05.2012

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Antiprotozoal agent.   The active ingredient is a derivative of 5-nitroimidazole. It has antimicrobial activity . The basic principle of the impact of based on the reduction 5- of the nitro group on the biourovne transport proteins the simplest and anaerobic microorganisms. After the reduction process the 5-nitro group of the drug begins to interact with the DNA of microorganisms, which leads to the inhibition of nucleic acid synthesis in microorganisms, causing the death of the bacteria and protozoa. Ornidazole no effect on the insensitive types of aerobic bacteria. Ornidazole produced in the form of tablets: vaginal, film coated.

Indications, contraindications:

Ornidazole prescribed for extra-intestinal form amebiasis , Trichomoniasis, for surgical interventions on the colon, in gynecological practice, with giardiasis, amoebic abscess genesis in the liver, intestinal amebiasis. Ornidazole not prescribed for the main component of the medication intolerance.

Side effect:

Ornidazole cause dizziness, headache, drowsiness, nausea, dyspepsia , Convulsions, impaired coordination of movement, muscle rigidity, tremor of limbs, increased liver enzymes, allergic reactions, perversion of taste, a mixed form of peripheral neuropathy, a temporary loss of consciousness, sensory neuropathy .

Mode of application:

Treatment of trichomoniasis: in combination with vaginal tablets Vaginal Ornidazole 500 mg administered once 1 gram inside; or shows a single dose of 1, 5 grams of the drug. The therapy is conducted 5 days, the first day administered 2 times 500 mg orally, 1 tablet intravaginally vaginal. Vaginal tablet inserted deep after careful antiseptic processing of external genital organs woman. Therapy extraintestinal forms of amebiasis: for 0, 5 grams twice a day, the course is designed for 5-10 days. Treatment for giardiasis: 1, 5 grams a day, the course is designed for 1-2 days. For the prevention of anaerobic infections Ornidazole prescribed in doses of 0, 5-1 grams before the surgery, after the surgery takes 3-5 days medication twice a day for 0, 5 grams.

Special instructions:

Protivotrihomoniaznaya Ornidazole therapy involves the simultaneous treatment of exposed sex partners.

Drug Interactions:

Ornidazole miorelaksiruyuschego lengthens the effect of the drug vecuronium bromide, significantly enhances the effectiveness of all coumarin anticoagulants . The distinctive feature in comparison with other imidazole derivatives (e.g., metronidazole) is that Ornidazole compatible with ethanol.