Description overdue on 11/11/2014
- Latin name: Neurobex
- ATC code: A11DB
- Active substance: Thiamine or Vitamin B1 nitrate + Pyridoxine hydrochloride or vitamin B6 + B12 is cyanocobalamin or vitamin (Thiamine + + Ryridoxine Syanocobalamin)
- Manufacturer: Balkanfarma AT-Dupnitsa, Bulgaria
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Neurobeks (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
One pellet includes in its membership the active substance: thiamine nitrate - 15 mg, pyridoxine hydrochloride - 10 mg, cyanocobalamin - 0, 02 mg.
Additional ingredients: lactose monohydrate, povidone, wheat starch, magnesium stearate, talc, colloidal silicon dioxide.
The shell composition includes sugar, cellulose acetate phthalate, gum arabic, talc, macrogol 400, macrogol 6000, glycerol and dye E124.
Product form
Produced product as pink round shaped tablets coated. The package includes 10 or 30 pieces.
Pharmacological action
Neurobeks - it combined preparation , Which included B vitamins .
Pharmacodynamics and pharmacokinetics
The action of vitamin preparations due to its constituent substances.
Thiamine Entering the body is subjected to phosphorylation, resulting in a kokarboksilaza - Coenzyme of many enzyme reactions. This material is necessary for the performance of carbohydrate, protein and fat metabolism, carrying nerve impulses in the synapses. At deficiency Vitamin B1 It accumulates in the body dairy and pyroracemic acid That often leads to polyneuritis, beriberi, Korsakoff's syndrome, Wernicke's encephalopathy, polyneuropathy, malfunction of the heart, damage to the gastrointestinal tract.
Pyridoxine essential for the full activity of the nervous system. The phosphorylated form of the substance - is coenzyme metabolism of amino acids and enzymes functioning in the nerve tissues. Also noted is involved in the biosynthesis of pyridoxine neurotransmitters : norepinephrine, epinephrine, dopamine, serotonin, GABA and histamine . The reason for the deficit of B6 may not be enough food, the problem of absorption in the gastrointestinal tract, reception of medicines - antagonists When radiation treatment. Deficiency symptoms appear seborrheic lesions around the nose and eyes, glossitis, stomatitis, peripheral neuritis, convulsive states and anemia .
Cyanocobalamine It participates in the process of hematopoiesis and provides a full maturation of red blood cells. Also, using B12 carried out important biochemical reactions that provide the vital activity of the human body - the transfer of methyl groups, the synthesis of proteins and nucleic acids, the exchange of amino acids, carbohydrates and lipids. This material affects the function of the nervous system: the production of RNA, DNA, and so on myelin. Coenzyme form cyanocobalamin - adenosylcobalamin and methylcobalamin required for growth and replication of cells. At deficiency vitamin B12 emergent adverse symptoms affecting the nervous system and hematopoiesis.
Erythropoiesis converted to megaloblastic and severe cases cause the development of pancytopenia. Disorders of the nervous system can occur irreversible damage - demyelination, loss of neurons in the spinal cord and the cerebral cortex, followed by unstable gait, paresthesia in the extremities, a violation of basic reflexes. At a later stage there may be mental disorders, hallucinations, mood swings, memory loss and vision, the development of psychosis.
Absorption thiamine and pyridoxine comes from the upper intestine is uniformly distributed in the body. The degree of absorption depends on the dosage of the drug.
Cyanocobalamine mainly absorbed in the upper intestine and stomach. The fabric material is delivered to the transport protein transcobalamin II. B vitamins that are part of this drug is metabolized in the liver.
Excretion from the body thiamine and pyridoxine carried out by the kidneys, high dose - through the intestines. Withdrawal cyanocobalamin It takes place in the bile, a small part of the kidney.
Indications
Neurobeks often prescribed in treatment when:
- asthenic syndrome, chronic fatigue syndrome, vegetative-vascular dystonia, encephalopathy, osteochondrosis, neuritis, polyneuritis, radiculitis, sciatica, neuralgia , Spastic states of central origin, myasthenia Traumatic lesions of CNS, and so forth;
- chronic circulatory failure, myocarditis, myocardial dystrophy Cardiovascular diseases;
- diabetes and its complications, obesity , Thyroid disease, disorders of metabolism of hormones hypothalamic-pituitary system;
- circulatory disorders of the retina, myopia, astigmatism, amblyopia, glaucoma, macular degeneration, optic neuritis, diabetic retinopathy, cataract;
- neurodermatitis, eczema, acne, dermatitis various origins , Herpes zoster;
- neuritis auditory nerve sensorineural hearing loss, labirintopatii;
- menstrual irregularities, mastitis, conservative treatment uterine fibroids, salpinogooforite, endometrial hormonal contraception;
- diseases of young children - diathesis, malnutrition, paratrofii The lag in the development of the child, in the period of intensive growth, recovery after infectious diseases, syndrome of school exclusion, cerebral palsy;
- antibiotic therapy , Chronic diseases, alcoholism In old age and in the diet.
Contraindications
Do not take this medicine if:
- acute thromboembolism;
- erythrose;
- eritremii;
- high sensitivity to its components.
Side effects
When treating Neurobeksom may develop allergic manifestations, such as: itching, hives.
Also available: tachycardia, nausea.
Instructions on Neurobeks (method and dosage)
This drug is used to treat adults and children from 2 years.
According to the instructions for use Neurobeksa, adult recommended daily intake of 2-3 tablets 3-4 times.
For children older than 10 years, the daily dosage is - one tablet 3 times, 5-10 years - one tablet 2 times a day, 2-5 years - one tablet once per day.
Treatment is carried out for a long time, on average - 2-3 months.
It is recommended to take the tablets at the same time or after a meal, as a whole, washed down with plenty of liquid.
Overdose
In cases of overdose in patients developing nervous excitement, pain in the heart, tachycardia.
This is carried out following treatment: gastric lavage, Activated carbon and other symptomatic therapy. It must be remembered that the antidote is pyridoxine isoniazid.
Cooperation
Concomitant use with oral contraceptives Neurobeksa drugs can reduce the content vitamin B6 in the body. Pyridoxine is able to provide a variety of effects on the metabolism of various drugs, as well as lowering the anti-Parkinsonian effect levodopa.
Antagonists vitamin B6 relate thiosemicarbazone and isoniazid . The positive effect of pyridoxine on the condition of patients in the sideroblastic anemia that cause these anti-TB drugs. Also deficit vitamin B6 may occur during long-term treatment penicillamine.
Antagonists pyridoxine represented by the compounds - cycloserine and hydralazine . The combination vitamin B6 and these antagonists are capable of lowering the neurological effects of these drugs.
During the reception Neurobeksa to refrain from the use of other multivitamin complexes, including in its composition B vitamins
Terms of sale
The drug is sold without a prescription.
Storage conditions
For storage Neurobeksa suitable dark, dry place inaccessible to children, with temperatures up to 25 ° C.
Shelf life
3 years.
Analogs
Neurobeks Forte
Milgamma
Milgamma Compositum
Neyrorubin
Analogs of this drug: Neurobeks Neo Neurobeks Forte Milgamma, Aevitum, Citoflavin, Neyrorubin and others.
Alcohol and Neurobeks
The combined use of alcohol and drugs Neurobeksa may reduce the absorption of thiamine in the body.
Reviews Neurobekse
As the reviews of Neurobekse, the most popular vitamin preparation is enjoyed by women. It shall take all who wish to improve the condition of the body - appearance, hair, nails and so on. However, many note the high efficiency of the funds, provided a full course of reception in addition to preparations of zinc, calcium, and vitamins A and C.
Women often say that under treatment at least twice a year. In addition, the common lot of reviews on the use of Neurobeksa after undergoing the complicated diseases. In most cases, therapy was highly effective.
Also at the forum found many discussions on the topic:
What is different from Neurobeks Neurobeks Forte?
As experts, the main difference of these drugs is that Neurobeks Forte Admission is contraindicated during pregnancy and patients under 14 years. The main reason for this is in the composition, the dosage of components and features of the impact on the human body.
Price Neurobeksa where to buy
Price Neurobeks in Moscow varies between 300-350 rubles. The cost of this drug in Ukraine is 107-120 UAH.
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