Xenical

Description overdue on 06.10.2011

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Main, an active substance - Orlistat . Drugs for weight loss. Xenical   is a specific inhibitor of gastrointestinal lipases, acting for a long time.

Therapeutic effect develops in the stomach and small intestine. Orlostat gastric and pancreatic lipases   (serine part) forms a strong covalent bonds. After inactivation of the enzyme is not able to break down fats, which come in the form of food triglycerides   on monoglycerides   and free fatty acids. Body weight decreased due to lower amount of digestible triglycerides. The therapeutic effect of the drug Xenical achieved without absorption into the systemic circulation. PM takes effect after 1-2 days. The normal absorption of fat recovered after 2 days after discontinuation of the drug.

Under the influence of orlostata reduced intake of fats, the body starts spending its own reserves, thereby achieving weight reduction. Xenical does not accumulate in the body, it does not affect internal organs. Orlostat does not cause dependence and addiction, you can take long courses.

Dosage Form:

Capsules.

Indications:

Long-term treatment of patients with obesity. The drug is taken in combination with hypoglycemic drugs in patients with type 2 diabetes.

Contraindications:

Cholestasis syndrome, chronic malabsorption, allergies.

Side effect:

GI: oily discharge from the feces, increased discharge of gases urgency to acts of defecation, loose stools, more frequent bowel movements, steatorrhea, discomfort in the epigastric region. These side effects increase with increasing fat content in the food received. The severity of side effects is reduced after 3 months of treatment. Marked increase in Alkaline phosphatase, liver transaminases . Rare pancreatitis, diverticulitis, rectal bleeding, cholelithiasis, bullous rash, dysmenorrhea, anxiety, headaches, urinary tract infections.

Mode of application:

Adults 1 capsule (120 mg) three times a day together with a meal. If the food contains a small amount of fat - intake of Xenical can be skipped. Increasing the dose of the drug did not lead to increased therapeutic effect. In pediatrics is not applicable.

Overdose:

With an increase in the recommended doses of the drug noted increased side effects. The symptoms are rapidly reversible.

Special instructions:

Xenical for weight loss is effectively used in long-term programs for the control of body weight. The drug reduces the risk of many diseases, reduces the amount of visceral fat.
During the period of treatment is recommended to include in the diet of plenty of fruits and vegetables. Daily Intake fats, proteins, carbohydrates   It must be spread evenly over 3 admission. Side effects from the gastrointestinal tract increased while taking the drug on a background of a diet rich in fats. The daily amount of fat must also be divided into 3 admission. Weight loss when taking drugs improves carbohydrate metabolism in diabetes mellitus type 2, which may require adjustment of doses of hypoglycemic agents.

Drug Interactions:

There was no interaction between the drug Xenical and biguanide, atorvastatin, amitriptyline, phenytoin, losartan, fluoxetine, warfarin, nifedipine, phentermine, pravastina   and others. The preparation can reduce the absorption of fat-soluble vitamins (betakaroten, vit. A, D, E, K).
An adequate supply of nutrients to the body is achieved by taking multivitamin complexes   before going to bed or after 3h or more after taking Xenical. Simultaneous treatment with cyclosporine   It reduces the plasma concentration of the latter. It is recommended to control the content of cyclosporine in the blood. Orlostat reduces the bioavailability dezetilamiodarona, amiodarone .
Do not combine the drug Xenical and acarbose .