Parlodel

Description overdue on 02/09/2013

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Dopamine receptor agonists.   The drug suppresses physiological lactation It inhibits prolactin inhibits hypersecretion of growth hormone promotes the stabilization of the menstrual cycle, reduces the number of cysts in the mammary gland and their sizes (due to restore the balance between the level of estrogens and progesterone). The drug stimulates the central and peripheral D2-dopamine receptors.

The active substance is an ergot alkaloid derivative. Large quantities of the medication is able to stimulate the receptors black nucleus and the striatum of the brain, the hypothalamus and mesolimbic system. The main ingredient in the drug Parlodel - bromocriptine . The drug is able to inhibit the hormone ACTH and growth hormone. Bromocriptine has antiparkinsonian effects . Receiving unit dosage rate decreases prolactin 2 hours, the maximum therapeutic effect is observed after 8 hours. Reduced levels of growth hormone occurs after 1-2 hours, the maximum effect is recorded after 4-8 weeks of therapy. Antiparkinsonian effect observed after 30-90 minutes, and the maximum - in 2 hours after administration of a single dose. Parlodel available in tablet dosage form.

Indications:

Instructions for use of the drug Parlodel recommends that prescribers in the menstrual cycle, female infertility: prolaktinzavisimye conditions and diseases that are accompanied or not accompanied by giperplolaktinemiey (luteal phase deficiency, oligomenorrhea, amenorrhea, hyperprolactinemia secondary to the background of antihypertensive drug therapy and psychoactive drugs). The drug is prescribed for premenstrual syndrome, manifested by swelling, breast tenderness, mood lability, increased flatulence. The drug is indicated for use in the prolaktinnezavisimom female infertility: the anovulatory cycles (in the complex therapy in conjunction with antiestragenami) in polycystic ovary syndrome.

Persons male Parlodel prescribed for prolaktinzavisimom hypogonadism (loss of libido, oligospermia, impotence). The drug is prescribed for prolactinoma: conservative therapy of pituitary microadenomas and macroadenomas, prolactin-secreting. Bromocriptine may be appointed before surgical treatment to reduce the size of the tumor and facilitate its lysis. The drug is used in an increased level of prolactin in the postoperative period. Acromegaly Parlodel used as further medicament in combination therapy in conjunction with surgical treatment or radiation therapy, and in some cases as an alternative radiation therapy and surgery.

The drug is prescribed to suppress lactation for medical reasons (for developing postpartum mastitis, to prevent lactation after an abortion at the postpartum breast engorgement). The drug is used in fibrocystic breast, cystic and nodular changes in the breast benign nature, with mastalgia. In Parkinson's disease Parlodel can be assigned to all stages of idiopathic disease in postencephalitic parkinsonism (monotherapy or combination therapy together with other antiparkinsonian drugs).

Contraindications:

Parlodel does not apply to endogenous psychosis , Chorea Gettingtona at family tremor, bromocriptine intolerance - the main substance of the drug, with hypertension in the postpartum stage, hypotension, ulcerative lesions of the digestive tract, essential tremor , Gestosis, arterial hypertension, diseases of the cardiovascular system. Simultaneous treatment of antihypertensive drugs, with gestation pregnancy, with symptoms of parkinsonism dementia   the drug is prescribed with caution. The active substance is excreted in milk during lactation, which limits the use of medication during breastfeeding.

Side effect:

Occasionally during treatment with bromocriptine developed orthostatic hypotension , Dizziness, vomiting and nausea. There are headaches, disturbances of vision, stroke, hypersomnia, psychomotor agitation, psychosis, hallucinations, constipation, myocardial infarction, psychomotor agitation , Dry mouth (orokandidoz, caries Discomfort, periodontal disease), skin rash, cramps in the calf muscles, allergic reactions, nasal congestion. Long-term therapy can bring to the development of Raynaud's syndrome.

In the treatment of Parkinson's disease with high doses of the drug may fainting , Bleeding from the digestive tract (in the form of black stool, and the appearance of blood in the vomit) peptic ulcer , The allocation of cerebrospinal fluid from the nose, confusion, retroperitoneal fibrosis   (frequent urination, nausea, back pain, loss of appetite, abdominal pain, vomiting, weakness in the whole body).

Overdose:

Manifested headaches, a fall in blood pressure. It is necessary to parenteral administration of the drug metoclopramide.

Mode of application:

Parlodel Inside, during a meal. At day - 100 mg. When female infertility, menstrual irregularities   bromocriptine taken three times a day for 1, 25 mg. In case of failure of the daily amount of medication may be increased to 5, -7, 5 mg. Therapy is conducted to restore ovulation, the stabilization of the menstrual cycle. Treatment involves several cycles, if necessary, prevent a recurrence. When hyperprolactinemia in males:   three times a day for 1, 25 mg 2-3 times a day with gradual increase in the daily dose of 5-10 mg. When premenstrual syndrome: on the 14th day of the menstrual cycle administered 1 25 mg per day, the amount of drug increased gradually to 5 mg per day (every day 1, 25 mg) to the onset of menstruation.

When prolaktinoma   administered 2-3 times a day for 1, 25 mg, DAILY amount of drug can be increased by the need to stabilize certain level of prolactin in blood. The initial dose is 1 acromegaly, 25 mg 2-3 times a day, further treatment strategy depends on the severity of side-effects and the clinical effectiveness of the medicament. For suppression of lactation   administered on the first day 1, 25 mg bromocriptine twice daily for 2 more weeks - 2, 5 mg twice a day. The drug is recommended to take immediately after birth to prevent the start of lactation (after stabilization of the mothers). Possible slight secretion of milk in 2-3 days after discontinuation of therapy. In this case, treatment is extended for one week at the same doses.

When postpartum breast engorgement   the drug is prescribed in a dose of 2, 5 mg dose, repeated reception is possible in 6-12 hours (does not cause an undesirable suppression of lactation). When developing postpartum mastitis   similar to the treatment regimen of therapy to suppress lactation. You can add to the antibiotic regimen. When benign breast Parlodel take 2-3 times a day 1, 25 mg of the drug daily amount gradually increased to 5-7, 5 mg.

In Parkinson's disease   treatment is initiated with minimal doses 1, 25 mg for optimum portability. Weekly, daily quantity of the medicament is increased by 1, 25 mg. The therapeutic effect is seen after 6-8 weeks of therapy. Otherwise weekly dose escalation continues. When side effects on the background of the selection and increase the dosage amount of the drug is reduced by 1 week. After stabilization of the titration continue. Patients with movement disorders caused by levodopa before drug treatment Perlodel lower dose of levodopa. In some cases, achieved a complete removal of the drug L-dopa.

Special instructions:

It requires regular monitoring of renal function, hepatic system, the level of blood pressure. For the prevention of vomiting, nausea before treatment is prescribed antiemetic medications. The drug affects the control of a motor vehicle and perform activities that require attention. Against the background of treatment with Parlodel may prompt restoration of ovaries after birth, which requires the use of contraceptives for the prevention of early conception.

Patients who take medication, pregnancy occurs when therapy is stopped except when the effect of the drug outweigh the potential risk to the fetus. During treatment, non-hormonal contraception is recommended that bromocriptine. In the event of pregnancy, a pituitary adenoma, after the cessation of treatment requires the study of the visual fields, the systematic observation of the adenoma. Responses to the drug Parlodel demonstrate high efficiency of medication in compliance with all medical prescriptions.

Before the treatment of benign tumors of the mammary glands necessarily exclude malignant nature of the tumor. If a peptic ulcer of the digestive tract bromocriptine therapy is not indicated. It is necessary to inform patients about the necessity of seeking medical help with the appearance of side effects from the digestive tract. It requires careful oral hygiene during treatment. Buy Parlodel drug can be in the pharmacy network upon presentation of a medical prescription form.

Drug Interactions:

Parlodel is able to reduce the effectiveness of oral contraceptives.   Clarithromycin, erythromycin and troleandomycin can increase the maximum concentration and bioavailability of the drug; butirofenov application leads to the opposite effect. Furazolidone, MAO inhibitors, selegiline, procarbazine, loxapine, haloperidol, ergot alkaloids, metoclopramide, methyldopa, reserpine, fenotiazidy, thioxanthine increase the risk of side effects by increasing the concentration of active substance in the blood plasma.

Parlodel increases the effect of antihypertensive agents, levodopa. Development disulfiramopodobnyh reactions   observed while taking ethanol (appears cough reflex tachycardia, flushing of the skin, chest pain, vomiting, nausea, convulsions, disturbances of vision, throbbing headache). If necessary, treatment with Ritonavir is necessary to reduce the daily dose of 2 times.