Livial

Description overdue on 08/19/2014

• Latin name: Livial
• ATC code: G03CX01
• Active substance: Tibolone (Tibolone)
• Manufacturer: Organon (Netherlands)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Livial, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Active substance - Tibolone   -2, 5 mg.

Excipients:

• 100 mg - lactose ;
• 10 mg - potato starch;
• 0, 2 mg - ascorbyl palmitate;
• 0, 5 mg -   magnesium stearate;
• purified water (removed during the production).

Product form

Available in tablet form with the active substance Tibolone   - 2, 5 mg.

The tablets are flat, round white, or close to it in color. The edges are bevelled tablets, embossed on different sides - «MK» on «2» + «ORGANON» and five-pointed star.

One package contains 28 tablets (1 blister) or 84 tablets (3 blisters).

Pharmacological action

Estrogen-progestin, antiklimaktericheskoe.

Pharmacodynamics and pharmacokinetics

The drug Livial exhibits estrogenic, progestogens, and weak androgenic activity. It helps stabilize the hypothalamic-pituitary system during menopause,   induces a decrease in generation gonadotropins .

In the period menopause   retards bone destruction attenuates these symptoms menopausal syndrome , as headache, increased sweating, "tides" of blood to the face.

A positive impact on the overall mood and libido, concentration increases due to the peripheral and central opioids . It does not have a stimulatory effect on the proliferation of the endometrium at the same time, stimulating the mucous membrane of the vagina. Suppress process Ovulation in fertile women.

Prevents the development of the disease - osteoporosis , Lowers serum calcium and phosphate.

Tibolone   It has a high absorption. The process of absorption following oral administration is rapid and completely.

Transformation occurs in the liver to release the active and inactive metabolic products.

Concentration Tibolone   in plasma are relatively low and reaches its peak after 60-90 minutes after the internal reception.

T1 / 2 metabolites of the drug is about 7 hours with no subsequent storage in the body.

It is shown mainly as metabolites via the kidneys. A small portion is excreted in the feces and bile.

Indications

• symptomatic therapy estrogen deficiency in postmenopausal women   women;
• prevention osteoporosis in postmenopausal women in women who are prone to frequent fractures and if you are hypersensitive to other groups of drugs used to prevent the disease.

Contraindications

• breastfeeding;
• pregnancy;
• vaginal bleeding of unknown etiology;
• the period of time less than 12 months since the last menstrual period;
• diagnosed or suspected malignant   mastoncus   (including history);
• endometrial hyperplasia untreated;
• diagnosed or suspected estrogen-dependent malignant tumors , in particular endometrial cancer   and others (including history);
• embolism and thrombosis   (arterial or venous) is there at present or in the past (including thrombophlebitis and deep vein thrombosis, myocardial infarction, pulmonary embolism, ischemic or hemorrhagic cerebrovascular disease );
• predtromboznye state (including angina pectoris and transient ischemic attack ) Occurring at present or observed in the past;
• confirmed thrombophilic diseases (including antithrombin deficiency, protein C or S);
• cardiovascular failure,   which is in the stage of decompensation;
• multiple or severe causes of possible development of arterial or venous thrombosis (including uncontrollable hypertension, atrial fibrillation, heart valve lesions with complications, infective endocarditis,   major surgery with prolonged   immobilization obesity , Extensive trauma);
• hepatic impairment;
• Acute liver disease or liver disease previously deferred, leading to changes in its functions;
• detected or previously diagnosed benign or malignant neoplasms of the liver (including liver adenoma );
• otosclerosis Which has developed in patients receiving hormonal contraceptives or during the previous term pregnancy;
• porphyria;
• rare hereditary diseases (including lactase deficiency, galactose intolerance, glucose-galactose malabsorption);
• hypersensitivity to Livia.

Precautions should be prescribed Livial:

• at uterine fibroids (leiomyomas) and / or endometriosis;
• at an elevated risk of developing estrogen-dependent tumors (e.g. mammary cancer Discovered in the immediate family);
• in cardiovascular disease without symptoms of decompensation;
• at a controlled hypertension;
• elevated levels of cholesterol in the blood;
• at cholelithiasis;
• at diabetes;
• systemic lupus erythematosus;
• when severe headaches or migraine;
• at epilepsy;
• at endometrial hyperplasia   history;
• in renal failure;
• at asthma;
• at otosclerosis, which is not associated with hormonal contraceptives or pregnancy.

Have any of these pathologies observed before or at the moment, it is a risk factor of aggravation or relapse during use Livia. If such condition of the patient is required to be under the constant supervision of a doctor.

Side effects

Digestive system:

• abdominal pain;
• dyspeptic disorders ( flatulence, diarrhea );
• liver dysfunction.

Central nervous system:

• dizziness;
• migraine;
• headache;
• Depression.

Endocrine system:

• weight changes;
• pretibial edema.

Reproductive system:

• thickening of the endometrium;
• vaginal discharge;
• bleeding or spotting from the vagina;
• genital itching;
• breast tenderness;
• vulvovaginal candidiasis;
• cervical dysplasia;
• pain in the pelvic area;
• vulvovaginitis.

Allergic symptoms:

• itching;
• seborrheic dermatitis;
• rash.

Others:

• blurred vision;
• fluid retention;
• pain in muscles and joints.

Livial, instructions for use (method and dosage)

Instructions on Livial recommends 1 tablet well as a daily dose of the drug. Adjust the dose of a drug based on the age of the patient, is not required. The tablet is trying to take the same time of day, and swallowing it whole with water.

The drug Livial is available in blisters on the underside of which marked with days of the week. The day you start taking the tablets should coincide with the day marked on the blister.

For example, when taking the first tablet should be taken on Monday tablet from the top row of the blister with marking - "Monday» (Mon). Further the drug is carried out successively (along the rows of pellets) according to the markings and the day of reception, including subsequent blisters.

During therapy, try not to miss the next dose and not to treatment interruptions, unless previously recommended by your doctor.

If you accidentally pass everyday Livian reception time, the next tablet should be taken as soon as possible for 12 hours.

At the end of 12 hours, skip this method and take the next pill in a blister pack at the usual time. Do not take double the dose to compensate the missed reception.

Overdose

Perhaps vaginal bleeding, nausea, feeling of malaise.

The most common symptoms of overdose are mild and require no specific treatment.

Cooperation

The drug may increase the effects Livial anticoagulants In this regard, subject to adjustment in the dose of the latter.

Barbiturates, hydantoins, carbamazepine, rifampicin, may enhance the metabolism Tibolone.

Medicaments containing composition St. John's wort (Hypericum perforatum ), Increase metabolism progestins and estrogens.

Terms of sale

Livial drug prescription.

Storage conditions

Livial Keep protected from light and away from children.

At a temperature of 2 ° C to 25 ° C.

Shelf life

2 years.

Cautions

The drug is not used as a contraceptive agent.

Livial is recommended to appoint not earlier than 12 months after the last menstrual period (natural menopause). When surgical menopause   the drug is prescribed immediately after surgery.

Livian exceed the daily dose (1 tablet) is not recommended because of the risk of bleeding from the vagina.

During treatment requires medical control of patients suffering epilepsy, migraine, diabetes, hypercholesterolemia, impaired renal function   (including history).

Analogs Livia

Among the drugs commonly prescribed hormone replacement therapy for menopause, there are analogues of Livia:

• Angelique;
• Femoston;
• Klimodien;
• Tsikloproginova;
• Klimonorma;
• Divina;
• Proginova   etc.

When searching for an effective drug in the period menopause   often discuss on the topic - which is better Angelique   or Livial; Femoston   or Ledibon   etc.

It is worth noting that while hormone replacement therapy menopause   may appoint only an experienced gynecologist, after a detailed examination
and anamnesis.

Therefore, to give an unambiguous answer to which of the existing products better: Livial, Angelique, Proginova   and others can not. Hormone therapy is selected individually for each patient, and conducted under the constant supervision of a physician in compliance with all of its recommendations.

Synonyms

• Velledien;
• Ledibon.

During pregnancy (and lactation)

The drug Livial is contraindicated during pregnancy and during breastfeeding.

Reviews Liviale

Doctors about Liviale, an individual approach to each patient, talking about it as an effective and relatively safe drug in the treatment of menopause.

Reviews of Women Liviale increasingly positive, although with reference to the various negative side effects. Recall that pick their own hormones can not. Adequate treatment can only assign a gynecologist.

Price Livian where to buy

Price Livia 2 tablets, 5 mg №28 in Russia range from 1,400 rubles to 2,000 rubles.

The drug Livial (2, 5 mg №28) can be bought in Moscow approximately for 1750 rubles.

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