Description overdue on 12/15/2014
- Latin name: Captopril
- ATC code: C09AA01
- Active substance: Captopril (Captopril)
- Manufacturer: KRKA (Slovenia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications captopril
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
The active component acts Captopril . Additional substances: lactose, anhydrous colloidal silica, maize starch, hydrogenated castor oil.
Product form
Captopril is available in tablet form. The dosage depends on the manufacturer. Acceptable dosages of 12.5, 25, 50 and 100 mg. The tablets are packed into blisters of 10 pieces. Each pack contains 2 cardboard blister and the instructions from the manufacturer.
Pharmacological action
The drug has hypotensive effects . Active substance inhibits the angiotensin converting enzyme, which inhibits transition angiotensin I to Form II. It Angiotensin II is a basic component of the renin-angiotensin system, which possesses a strong vasoconstrictive (vasoconstrictor) effect. By reducing levels of angiotensin II, a decrease in production of aldosterone and due to the accumulation of vasodilating substance bradykinin hypotensive effect is achieved.
The drug reduces the overall resistance of the flow of blood vessels, lowers blood pressure, and afterload in the pulmonary circulation. Medicine for further pressure capable of reducing the level of aldosterone in the adrenal glands.
Pharmacodynamics and pharmacokinetics
About 75% of the active substance sufficiently rapidly absorbed from the digestive system. Food intake may reduce the absorption of 30-40%. The maximum level of active substance in the blood is recorded after 30-90 minutes. Albumin binds to the active ingredient is 25-30%.
Captopril is excreted in milk during lactation. Metabolism It carried out in hepatic system. Metabolites not possess pharmacological activity. 95% of the medicament is output via the renal system, almost half - in its original form, the remaining part - in the form of metabolites. In severe renal pathology observed effect cumulation (accumulation).
Indications captopril
Captopril Tablets by what? The drug is mainly used for relief hypertensive crisis , Reduction blood pressure .
The main indications for the use of captopril:
- renal hypertension ;
- essential hypertension (rise in blood pressure of unknown etiology);
- malignant hypertension (with resistance to other medications).
From what Captopril Agos? Indications Captopril Agos:
- diabetic nephropathy patients diabetes (type 1);
- left ventricular dysfunction in patients who underwent myocardial infarction and achieved a clinically stable condition.
Contraindications
Captopril Tablets pressure are widely used in cardiology practice, but have certain contraindications:
- narrowing of the aorta;
- primary hyperaldosteronism ;
- narrowing of the mitral valve;
- condition after kidney transplantation;
- vynashivanie pregnancy ;
- renal artery stenosis ;
- tendency to edema;
- Individual hypersensitivity ;
- myocardiopathy ;
- breast-feeding .
In pediatric medicine can only be assigned upon reaching 14 years of age. Patients are advised to abstain from work that requires concentration.
Side effects
From the nervous system may occur following side effects:
- paresthesia;
- migraine headache ;
- dizziness ;
- asthenia;
- fatigue.
Cardiovascular system:
- heart palpitations;
- orthostatic hypotension.
The digestive tract:
- pancreatitis ;
- cholestasis;
- violations of the chair ( diarrheal syndrome or constipation );
- epigastric pain;
- violation of taste perception;
- nausea;
- hepatitis ;
- level increase bilirubin ;
- increase in ALT and AST.
Hematopoietic system:
- reducing the number of Platelet ;
- anemia ;
- neutropenia;
- agranulocytosis (if any autoimmune disease).
Metabolism:
- acidosis;
- increase in K + in the body.
Urinary system:
- abnormalities in the kidneys;
- detection of protein in urine.
In some cases, it recorded a dry, nonproductive cough. There are allergic responses :
- bronchospasm;
- the presence of anti-nuclear antibodies;
- angioedema ;
- lymphadenopathy ;
- serum sickness .
When registering other adverse reactions should be consulted doctors and temporal self-removal of the drug captopril.
Instructions for use (method and dosage)
The tablets are for oral use. The drug quickly enough to reduce blood pressure. Only a doctor can prescribe pills Captopril. Instructions for use PNDS crises : 25 mg dose tablet placed under the tongue that allows faster hypotensive effect. Instructions for use Captopril Akos renovascular hypertension in the form : Three times a day for 12, 5 mg. Efficacy increases when taken on an empty stomach.
Treatment with captopril STADA recommended to start with small dosages: 6, 25-12, 5 mg twice a day, gradually increasing the dosage depending on the blood pressure.
How to take the medication Heart failure : three times a day to 12 mg of 5-25. The maximum daily dozirovka- 150 mg.
What pressure to take captopril? The drug belongs to a group of medicines "ambulance" and is recommended for use in cases of emergency, when treatment with the standard scheme was increased pressure to high numbers of the stress, physical exertion.
Overdose
Improper use of pills overdose can happen, which is shown a pronounced decrease in blood pressure levels. The patient can get complicated thromboembolism . cerebrovascular blood supply , Myocardial infarction.
It is recommended to give the patient a horizontal position, raise the lower limbs, to try to restore blood pressure by intravenous infusion of normal saline. Peritoneal Dialysis It does not give the desired effect. On the background Hemodialysis positive dynamics.
Cooperation
Together with cytostatics and immunosuppressants may develop leukopenia . Perhaps the development of hyperkalemia in the concurrent therapy potassium-sparing diuretics:
- Amiloride;
- Spironolactone;
- Triamterene .
The treatment Azathioprine may develop anemia due to inhibition of the activity Erythropoietin . The medical literature describes cases of leukopenia diagnosis-related additive bone marrow hematopoiesis. Allopurinol It may enhance the severity of hematological influence. Acetylsalicylic acid is able to reduce the hypotensive effect of captopril. The drug is able to increase the concentration Digoxin . The most common drug interactions seen in patients with severe renal pathology system. Captopril with Cinnarizinum not contraindicated.
Terms of sale
It is recommended to bring a prescription in Latin:
Rp. Tab. Captoprili 25 mg of
D.t.d. 20 N
S. 1 tablet under the tongue.
Storage conditions
The manufacturer recommended temperature in the range of 15-25 degrees. Restrict the admission of children to blister.
Shelf life
4 years.
Cautions
What's better Captopril or Capoten ? These two drugs are identical, because the active substance in them INN Captopril acts. The main difference in the hood and captopril Manufacturer.
During treatment, a false positive reaction can be detected in the determination of acetone in urine. The pediatric medicament may be used in the absence of the effect of other antihypertensives.
Analogs of captopril
Monopril
Renitek
Charter
Fozikard
Amprilan
Ramipril
Perindopril
Prestarium
Perineva
Capoten
Berlipril
Akkupro
Diroton
Enap
Enalapril
Structural analogues of captopril:
- Kaptopres;
- A cowl;
- Alkadienes.
Captopril and alcohol
Alcohol can increase the hypotensive effect of the drug. There sharing a negative impact on the work of the hepatic system.
Reviews of captopril
This is one of the most talked about of antihypertensive drugs on the Internet. Many patients share their years of experience captopril and note its high efficiency in emergency cases where the normal daily therapy does not work and the pressure remains high numbers. There are reviews of captopril, among which is often described side effects such as dry cough, is characteristic of all the medicines group ACE inhibitors. In general, patient testimonials about the positive captopril.
Price captopril, where to buy
Captopril is the most affordable of antihypertensive drugs, which can be found in the home medicine cabinet every hypertensive. The cost of the medication depends on the dosage, the manufacturer and the sales region. Price captopril in Russia is in the range of 20-140 rubles (captopril Akos - 20 rubles, Captopril Sandoz - 140 rubles).
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