Veroshpiron

Description overdue on 07.09.2011

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The main ingredient - spironalokton . Veroshpiron - Competitors aldosterone antagonist . potassium-sparing diuretic . Spironalokton in the distal nephron prevents water retention of sodium and aldosterone reduces kaliyvyvodyaschee action of aldosterone decreases Synthesis permeases . The maximal effect of the drug observed after 7 h after administration of the capsule, last for 24 hours. The decrease in blood pressure is achieved diuretic effect, it appears after 2-5 weeks of treatment.

Indications:

Veroshpiron used in a combination therapy with essential hypertension . The drug is effective When edema in chronic heart failure, nephrotic syndrome, ascites, cirrhosis of the liver. As an adjuvant in preventing hypomagnesemia / hypokalemia   with diuretics. The drug has been used successfully in the Cohn syndrome   in a short period of pre-treatment as well as for the purpose of diagnosis " Primary hyperaldosteronism ".

Contraindications:

Veroshpiron contraindicated in case of hypersensitivity to the components of the drug, hyperkalemia, hyponatremia, Addison's disease . anurii , Severe renal insufficiency (creatinine clearance less than 10 ml / min), pregnancy and lactation. With extreme caution in metabolic drug prescribed acidosis , Hypercalcemia, AV-blockade, diabetes mellitus, diabetic nephropathy, menstrual irregularities, carrying out general and local anesthesia for liver, kidney, and the elderly.

Side effects:

Gastrointestinal tract : Diarrhea, nausea, vomiting, gastritis . constipation , Intestinal colic, liver malfunction.

Central nervous system : Lethargy, ataxia, headaches, dizziness, lethargy, drowsiness, muscle spasms, confusion, leg cramps.

Forming Organs Thrombocytopenia, agranulocytosis, megaloblastoz.

Metabolism : Hypercreatininemia, hyperuricemia, hyperkalemia, increased levels of urea, hyponatremia, hyperchloraemic metabolic alkalosis and acidosis.

Endocrine system : Men may develop gynecomastia, Erectile Dysfunction , Reduced potency. Women can amenorrhea , Dimenoreya, hirsutism , Terorragii, breast carcinoma.

Allergic reaction : Itching, drug fever, urticaria, erythematous, maculo-papular rash.

Dermatological reactions : Hypertrichosis, alopecia .

The urinary system : Acute renal failure.

Mode of application:

Essential hypertension Adults: 50-100 mg once daily. The dosage may be gradually increased up to 200 mg, the amount of drug increased 1 time in 2 weeks.

Idiopathic hyperaldosteronism : 100-400 mg per day.

Expressed hyperaldosteronism, hypokalemia : 300 mg per day for 2-3 hours. Gradually reduce the dose of 25 mg per day.

Hypomagnesemia, nipokaliemiya provoked by the action of diuretics : 25-100 mg per day, once or in several stages.

Diagnosis and treatment of primary hyperaldosteronism : 400 mg a day for 4 days. The daily dose is divided into several stages.

Edema in nephrotic syndrome : 100-200 mg per adult per day. Veroshpiron used only if other treatments have proved ineffective.

Edematous syndrome in CHF : 100-200 mg per day (multiple doses) for 5 days in combination with a thiazide and "loop" diuretics. The daily dose can be reduced to 25 mg.

Swelling cirrhosis : The ratio of Na + / K + in urine above 1, 0, 100 mg is prescribed. If less than 1, 0, the daily dose - 200-400 mg.

Edema in Children : Initially 1-3, 3 mg per 1 kg of body weight, or 30-90 mg / m2 per day for 1-4 reception. After 5 days, the correction of the dose.

Special instructions:

Veroshpiron in gynecology prescribed to reduce the rate of androgens in women with PCOS ( polycystic ovary syndrome ). The drug can cause bleeding, disrupt the menstrual cycle. Veroshpiron often advised to take in conjunction with contraceptives to normalize menstrual cycles, reduce hirsutism.

Overdose:

Symptoms include diarrhea, dizziness, nausea, vomiting, skin rashes. Treatment is aimed at flushing the stomach, high blood pressure.

Interaction with other drugs:

The drug reduces the effectiveness of mitotane . anticoagulants It increases the effect of diuretics and antihypertensive. Stimulating effect buserelina . triptorelin . gonadorelin . When concomitantly with potassium supplements increase the risk of hyperkalemia. It reduces the toxicity of cardiac glycosides. Indomethacin Salicylates reduce the diuretic effect of the drug. Veroshpiron increases the metabolism of antipyrine, increases the half-life Digoxin .