Description overdue on 09/18/2013
- Solu-Medrol Price
- Powder cough Fluifort
- Kartilag Vitrum, instructions for use
- Luvox Antidepressant
In the treatment of aspirin reduces the risk of an unstable form of angina, myocardial infarction, reduced mortality rates from diseases of the cardiovascular system. The drug Aspinat effectively used for primary and secondary prevention of myocardial infarction, especially in males over 40 years old. The daily dosage of 6 mg increases the rate of prothrombin time and inhibits the synthesis of prothrombin in the hepatic system. It is important to bear in mind that in patients receiving aspirin significantly increases the risk of bleeding, and various hemorrhagic complications during and after surgery. Aspinat reduces the concentration of vitamin K dependent clotting factors 2, 7, 9 and 10. The medicaments enhances fibrinolytic activity of blood plasma, stimulates excretion Uric acid from the body in small amounts (by disrupting reabsorption in the renal tubule system). When the blockade of cyclooxygenase-1 in the gastric mucosa decreases gastroprotective activity (protective) prostaglandins, which can cause ulceration of the stomach wall and the development of bleeding. The least irritating to the mucous wall of the stomach have a special "sparkling" form of acetylsalicylic acid, and enteric dosage forms which include buffering agents.
Indications:
Aspinat prescribed for relief febrile syndrome Which accompanies many infectious and inflammatory diseases. Currently, acetylsalicylic acid is not used to treat pericarditis Rheumatoid arthritis, Rheumatic chorea . rheumatism and infectious-allergic myocarditis . Drug Usage Aspinat recommends prescribers to achieve the antiplatelet effect (at a dose of 300 mg per day) in patients with unstable angina, coronary heart disease, repeated myocardial infarction, ischemic stroke, with prosthetic heart valves, to stent placement, after the coronary balloon angioplasty . The drug is used to relieve pain of various origins: lumbago , Arthralgia, headache (including migraine pain caused by alcohol withdrawal syndrome), neuralgia, toothache, tuberculosis, thoracic radicular syndrome, pain in the muscles. The Allergy and Clinical Immunology Aspinat recommended for use in increasing doses for the development of persistent tolerance (stability) to NSAIDs in patients "Aspirin triad" and "Aspirin asthma" .
Contraindications:
Aspinat not indicated in case of intolerance of acetylsalicylic acid, ulcers and erosive lesions of the digestive system (acute stage), with "aspirin" triad of a history of bleeding from the gastrointestinal tract, haemorrhagic diathesis , Recurrent nasal polyposis, paranasal sinuses, with gipoprotrombinemii , Hemophilia, thrombocytopenic purpura , Von Willebrand disease, intolerance to medications pirazolonovogo row, thrombocytopenia, telangiectasia. The drug is not prescribed for deficit Vitamin K . dissecting aortic aneurysm At gestation gestation, portal hypertension, kidney disease and liver, with inadequate glucose-6-phosphate dehydrogenase. When decompensated form of chronic heart failure, renal pathology system in ulcerative diseases of the stomach and duodenal ulcers, gout, urate nefrourolitiaze , Hyperuricemia Aspinat used with caution when evaluating the possible risks of the therapy.
Side effect:
The treatment may experience nausea, diarrhea, Reye's syndrome (rapid formation of liver failure, acute fatty liver, and encephalopathy), appetite disorders, allergic responses in the form of bronchospasm, skin rash and angioedema. Aspirin can cause "aspirin triad" and "aspirin asthma" due to the formation haptenated mechanism. Long-term treatment is accompanied by headaches, disturbance of vision, erosive and ulcerative lesions of the digestive system, tinnitus, vomiting, dizziness, nephrotic syndrome , Papillary necrosis, bronchospasm, a violation of auditory perception, anticoagulation , Interstitial nephritis, hypercalcemia, pre-renal azotemia, edema, hepatic enzyme elevations system increased symptoms of chronic heart failure, aseptic meningitis .
Overdose:
High doses leads to the development Aspinata syndrome salitsizma Headaches, tinnitus, fever, disturbance of vision, vomiting and nausea. In severe poisoning notes metabolic acidosis , Hyperventilation (at central level), cyanosis, suffocation , Respiratory alkalosis, respiratory acidosis. When poisoning moderate requiring emergency hospitalization and treatment in the hospital: designation laxatives, control electrolyte balance and CBS, activated carbon and other ehnterosorbentov introduction sodium lactate, sodium citrate, sodium hydrogencarbonate, depending on the state of the metabolic processes. At the expense of oshchelachivanija of urine is amplified the excretion of Aspinata at increase of reserve alkalinity. Alkalinization urine achieved by intravenous infusion of sodium hydrogen carbonate. Special care is required Elderly patients who have an increased risk of pulmonary edema during an intense infusion of fluid. For alkalinization urine acetazolamide is not recommended because of the risk of acidemia and increased toxic effects of salicylates. At the level of more than 100-130 mg of salicylate%, with severe lesions of the central nervous system, in refractory acidosis, renal failure, pulmonary edema, progressive deterioration of the general condition prescribed hemodialysis. When pulmonary edema requires mechanical ventilation with a special mixture enriched with oxygen.
Mode of application:
Soluble tablets Aspinat recommended before use to dissolve in a small amount of the liquid 2-3 times daily and 400-800 mg (but no more than 6 grams). Aspirin in doses 50-70-100-300-325 mg is used to achieve antiplatelet effect ; in a dose more 325 mg - for Achievements analgesic and anti-inflammatory effect . In the acute form of rheumatism administered 100 mg per 1 kg a day for 5-6 doses. When expressed pain and fever syndromes Adults appoint 0, 5-1 grams per day (3 admission). The duration of therapy Aspinatom should not exceed 14 days. Effervescent medicament form to be dissolved in 100-200 mL of water prior to ingestion, preferably after the meal. Duration of treatment may vary from one reception to a few months. Patients with myocardial infarction, prescribe medication for secondary prevention dose of 40-325 mg per day (mean dose of 160mg). Improvement of the rheological properties of blood is achieved by using 0, 15-0, 25 grams of aspirin a day (therapy designed for a few months). At a dose of 300-325 mg per day of the drug inhibits cell aggregation of blood platelets. With tromboemboliah cerebral genesis in dynamic circulatory disorders of the brain in males administered 325 mg per day (the amount of the drug is gradually increased to 1 gram per day). Relapse prevention is achieved by taking 125-300 mg per day. To prevent occlusion of the aortic graft thrombosis and recommended the introduction of the drug through a special gastric tube mounted intranasally at a dose of 325 mg every 7 hours. Further it recommended oral aspirin three times a day 325 mg (usually appoint more dipyridamole for a week).
Special instructions:
Aspirin with prolonged use causes NSAID-gastropathy (a day is recommended to appoint no more than 5-8 grams). As an antipyretic Aspinat can apply no more than three days and for pain relief - no more than a week. Patients should be warned before the operation surgeons abdominal surgery and other interventions about taking aspirin to prevent heavy blood loss. Be sure to study fecal occult blood and evaluation of the state of the blood. Not to prescribe drugs containing acetylsalicylic acid to children because of the high risk of Reye's syndrome (a long and uncontrollable vomiting, severe forms of encephalopathy development, enlargement of the liver). Enteric form acetylsalicylic acid have the least Irritation of the digestive tract wall. Aspinat able to provide teratogenecity when used during child bearing. The active substance is excreted in breast milk during breastfeeding, which significantly increases the risk of bleeding in children infants because of functional disorders in platelet blood cells. In individuals predisposed to gout medication could trigger another attack due to the accumulation of uric acid in the body. Unacceptable use of alcoholic beverages while taking aspirin.
Drug Interactions:
Aspinat increases the toxicity of heparin, sulfonamides, hypoglycemic agents, narcotic analgesics, reserpine , Co-trimoxazole, anticoagulants . Methotrexate , Platelet aggregation inhibitors, cell thrombolytics. The drug is able to reduce the effectiveness of the impact of diuretic drugs ( Furosemide , Veroshpiron), antihypertensive medications. The risk of gastrointestinal bleeding increases significantly while taking ethanol-containing preparations, glucocorticosteroids . Gematotoksichnosti Aspinata increases in the treatment of myelotoxic agents. Antacid medicines impair the absorption of acetylsalicylic acid.
No comments:
Post a Comment