Benarin

Description overdue on 11.02.2012

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Glucocorticosteroids.   Active substance - budesonide . It has anti-allergy and anti-inflammatory effects. It is based on strengthening development lipokortina - An inhibitor of phospholipase A2, which leads to reduced production arachidonic acid , Inhibition of the process of synthesizing prostaglandins   and endoperekisey Which are products of arachidonic acid metabolism. Benarin reduces the speed of the processes granulation   and Infiltration It inhibits the migration of macrophages, inhibits the formation Substance chemotaxis reduces the production of cytokines, reduces the inflammatory exudation, prevents the formation of regional clusters of neutrophils. Under the action of budesonide reduced the release of inflammatory mediators from mast cells That inhibits the development of chronic allergic rhinitis and chain reactions. With prolonged use Benarin well tolerated, does not have a resorptive effect. Significant therapeutic effect is formed after 1-3 weeks. Benarin available as a nasal spray, drops.

Indications and contraindications:

Benarin indicated for allergic rhinitis (seasonal and year-round variants of the course). Spray Benarin used in inflammatory processes in nasal noninfectious origin, for preventing the growth of nasal polyps to be effective in vasomotor rhinitis . Benarin not prescribed for   pulmonary tuberculosis , Viral, fungal and bacterial respiratory lesions. Budesonide does not apply to fresh trauma of the nose, in the acute period after surgical treatment for nasal cavity, pregnancy, breastfeeding, in pediatric practice before reaching adulthood.

Side effects and overdose:

Use of the drug Benarin may be accompanied by irritation of the mucous membrane in the nasal cavity, a burning sensation, itching. Perhaps the development of bleeding, allergic reactions, headache, sore throat, sneezing Dizziness. Rarely recorded ulceration, atrophy of the mucosa, increased intraocular pressure, conjunctival hyperemia , Nasal septum perforation, dyspepsia, cough, increased drowsiness, myalgia, vomiting, growth retardation, candidiasis throat candidiasis of the nasal cavity , Nasal congestion, heart palpitations, stomachalgia . If overdose is formed Cushing's syndrome . acne . dysmenorrhea . It recommended a gradual reduction in dose drug Benarin.

Mode of application:

Spray Benarin:   2 injection (total 100mcg) in each nostril, twice a day. Supportive therapy - 1 dose twice a day, or a double dose in the morning. Drops Benarin:   2-3 drops (50-150 mcg) instilled into each nostril. At night no more than 400 micrograms. The course of treatment up to 3 months. If you forget to apply a dose of the drug as soon as possible, the planned dose should go to the body, not earlier than one hour.

Special instructions:

If you get the drug into the eyes formed corneal ulceration. The transition from a system of glucocorticosteroid on topical glucocorticosteroid may trigger the development of syndrome adrenal insufficiency . Achieving therapeutic effect in the treatment of allergic rhinitis is performed during regular use of the drug.

Drug Interactions:

Ketoconazole Estrogens increase the efficiency and methandrostenolone Benarina. Rifampicin, phenobarbital and phenytoin - reduce the effectiveness of the drug.