Reopirin

Description overdue on 24.01.2012

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Non-narcotic analgesics . It is a combined drug containing phenylbutazone, aminophenazone. It has antipyretic, analgesic and anti-inflammatory effects. The mechanism of action is based on inhibition of synthesis prostaglandins . Reopirin comes in the form of pills, injectable solution.

Indications and contraindications:

Reopirin prescribed for ankylosing spondylitis, gouty arthritis, rheumatoid arthritis   and other non-infectious arthritis. The drug is effective at Parameters , Adnexitis, retinitis, iridocyclitis , Iritis, polyneuritis , Neuralgia, polyserositis, pericarditis, lumbago . Reopirin not apply when failure renal / hepatic systems leukopenia , Inhibition of bone marrow hematopoiesis, ulcerative lesions of the digestive tract, heart disease, arrhythmias, heart failure, intolerance aminophenazone and phenylbutazone. Injectable forms are contraindicated in epilepsy , Tendency to spazmofilii .

Side effect:

The drug Reopirin can cause fluid retention, ulcerative lesions of the digestive system, diarrhea, vomiting, dyspepsia, dizziness, increased drowsiness, tachycardia, neuritis, thrombocytopenia, anemia, tubular necrosis   in the renal system, hematuria, glycosuria, allergies. At the injection site may occur sterile abscess , Pain.

Overdose:

Higher doses of the drug causes increased severity of side effects, disruption of water and electrolyte metabolism, increased body temperature, convulsions , Coma, psychosis, hallucinations , Vomiting with blood. After 2-7 days celebrated hypocoagulation , Increased bleeding, disturbances on the ECG, jaundice, swelling, disruption of the hepatic system. Requires posimptomnaya therapy.

Mode of application:

Parametritis , Adnexitis: until disappearance main signs of inflammation every five days intramuscularly injected with 5 ml. Inside take 4-6 pills daily. Rheumatic diseases:   solution is introduced slowly, deep intramuscularly in the gluteal muscles using a long needle, 5 ml each day.

Special instructions:

Reopirin in pills prescribed as maintenance therapy, and in extreme cases, in the acute stage of the disease is recommended intramuscular administration of the drug. In pediatric appoint an exceptional testimony, only in a hospital, regularly assessing hepatic function of controlling the state of the blood. Long-term therapy requires an assessment of the dynamics of the number of leukocytes.

Drug Interactions:

Reopirin enhances the action of barbiturates, sulfonamides . anticoagulants , Hypoglycemic drugs. The drug weakens cephalosporins . griseofulvin , Phenytoin, imipramine. Myelotoxic drugs increase haematotoxicity reopirin.