Prozhestozhel

Description overdue on 08/12/2014

• Latin name: Progestogel
• ATC code: G03DA04
• Active substance: Progesterone (Progesterone)
• Manufacturer: Besins Healthcare, Belgium

Photos of the drug

Tweet

• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications for use of the drug
• Contraindications
• Side effects
• Instructions on Prozhestozhel (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

In Progestogel gel contained 10 mg or 1 g of active substance - progesterone.

Supporting components are: carbomer 934, triethanolamine, polyoxyethylene, ethyl alcohol, purified water, 2-octyl-dodecanol, and polyoxyethylated hydrogenated castor oil.

Product form

Produced product in the form of 1% gel packed in 80 g tube.

Pharmacological action

The gel has progestational .

Pharmacodynamics and pharmacokinetics

This ointment is for external use in the treatment of mastodynia . Active ingredient progesterone   providing blocking action for estrogen receptors, a process which improves the suction of the liquid from the tissue and decreasing tightness ducts. Concurrently noted blocking prolactin receptor in the mammary gland, leads to a decrease in laktopoeza . Generally Prozhestozhel begins to act by increasing the concentration of active substance in the tissue of the breast .

Use of the drug, even if the creation of a high concentration progesterone   the site of application, does not cause systemic effects and undesirable effects.

Also, there was some natriydiureticheskoe action   as a result of inhibition of tubular reabsorption and increased cell filter that prevents fluid retention during transformation secretory mammary gland glandular component and pain syndromes.

With   transdermal route   introduction progestogen   has a significant impact on the vasculature and glandular epithelium, thereby decreasing the permeability of capillaries, decreases swelling breast tissue eliminates the symptoms mastalgia.

The transdermal method of using the gel facilitates the rapid penetration in the breast tissue, bypassing the process of destruction of the liver and does not cause undesirable systemic action in the body. When this absorption progesterone   It is about 10% of the dose and stored at least one hour after application of the drug without altering the hormonal level.

With skin application in the breast creates a high concentration at the site of application, even at smaller doses.

Second metabolism   drug in the liver. This produces conjugates with sulfuric acid and glucuronic acid. In addition, it noted the participation of isoenzyme CYP2C19.

Withdrawal of the drug mainly with kidney - which is about 50-60%, and a small amount in the bile, about 10%. The number of metabolites that are excreted through the kidneys depends on luteal phase.

Indications for use of the drug

Gel Prozhestozhel administered in combination therapy:

• at fibroadenoma;
• at mastodynia and other diseases of the breast tissue.

Before you start using this tool, you can see Picture how to apply the gel   on the affected area.

Contraindications

It is not recommended to use this tool in the outer:

• nodular fibrocystic breast;
• tumors   and tumor formations in the mammary glands of unknown origin;
• monotherapy Breast Cancer   or sex organs;
• II and III trimesters pregnancy ;
• intolerance or hypersensitivity to the drug and so on.

Caution should apply the gel to patients who have a hepatic, renal failure, asthma, epilepsy, migraine, depression, ectopic pregnancy, propensity to thrombosis, acute forms of phlebitis, diabetes, hypertension   and other diseases or special states.

Side effects

In rare cases the use of gel may cause disturbances in the activity of the reproductive system, such as:

• improving breast tenderness;
• the strong rush of blood;
• decreased libido;
• metrorrhagia.

In addition, there may be allergic reactions   - irritation at the site of application, swelling of the lips and neck, fever, headache, nausea   and other.

Instructions on Prozhestozhel (method and dosage)

This ointment is administered transdermally by. To calculate the daily dose used special spatula dispenser of plastic. When you need to apply the gel Prozhestozhel, instructions for use advises click on the tube at a location above the line spatula. One dose corresponds to the length of the column of gel grooves on the line. Typically, the tube is enough for 30 doses.

Extruded means applied to the skin surface of each Breast . Women often question the accuracy of the application of this tool and would like to see Video "How to apply correctly Prozhestozhel" . However, in this process, no big deal. To carry out this procedure you need every day, regardless of the frequency of the menstrual cycle or during the specified person. After application, the gel must fully absorb into the skin. The average duration of treatment is 3 months. To carry out re-treatment is necessary doctor's appointment.

Overdose

Cases of overdose of this tool is unlikely due to its low systemic absorption.

Cooperation

Simultaneous use Combined hormonal contraceptives   It enhances the effect of the gel.

Terms of sale

Holiday preparation is carried out with a prescription.

Storage conditions

It is recommended to store the gel at a temperature of 25 ° C, out of reach of children.

Shelf life

3 years.

Analogs

Match code ATC 4th level:

• Progesterone is
• Depo-Provera
• Utrozhestan

Main counterparts Prozhestozhelya: Utrozhestan, Progesterone, ehndometrin.

Alcohol and Prozhestozhel

The manufacturer's instructions are no data on the interaction of the tool with alcohol. According to experts, the joint use of alcohol is possible, but in reasonable quantities.

Reviews Prozhestozhel

It should be noted that many patients using the gel Prozhestozhel, reviews of which a very different character. Women often report on its effectiveness, such as through the use of external tools "soften sealing reduces pain" improves the general condition of the female body. However, there are also reviews of patients as a result of the treatment gel on the contrary, they began to feel severe pain, hardening and roughness at the application site. Other ladies simply afraid to use hormones, believing that they further undermine health.

This reviews the doctors indicate that accessing specialist performed a full selection of complex treatment, of which often include Prozhestozhel. If treatment is started promptly, in most cases, it is highly effective. The main problem is the fact that women are not in a hurry to see a doctor, trying to make ways to eliminate the unpleasant symptoms of traditional medicine. This approach, and causes severe consequences to the development of pathologies, significantly complicating further treatment.

Price Prozhestozhel where to buy

As it turned out, the price Prozhestozhel pharmacies in Moscow varies 445-577 rubles. About the same price Prozhestozhel gel is observed in other Russian regions. To carry out a course of treatment may be required 2-3 tube preparation.

Get the best price and buy