Description overdue on 04/23/2014
- Latin name: Perineva
- ATC code: C09AA04
- Active substance: Perindopril
- Manufacturer: LLC "Krka Pharma" Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Perinevy (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
Medicine Perineva includes the following components:
- perindopril erbumine;
- lactose monohydrate, calcium chloride hexahydrate, Valium;
- colloidal silicon dioxide, MCC, magnesium stearate.
Product form
The drug comes in the form of a round biconvex white tablets with Valium on one party of 8, 4 and 2 mg. The blister pack is 10, 14 or 30 tablets.
Pharmacological action
Perineva has a hypotensive, vasodilating and cardioprotective effects.
Pharmacodynamics and pharmacokinetics
Perindopril has a therapeutic effect due perindoprilat (active metabolite). It reduces the systolic and diastolic blood pressure, systemic vascular resistance, resulting in decreased blood pressure. Peripheral blood flow while accelerating, but the pulse does not increase.
The maximum effect occurs after taking an average of 4-6 hours, and persists for days.
Arterial pressure reduced quickly enough. Stabilization of the pressure is observed after about a month of therapy. After cessation of treatment withdrawal symptoms do not develop.
It increases the elasticity of the arteries, helps to eliminate their structural changes. It normalizes the heart muscle, reduces preload and afterload .
The maximum concentration perindopril in the blood observed after taking an hour. It is rapidly absorbed from the gastrointestinal tract. Bioavailability - 65-70%.
Simultaneous food intake with the drug reduces the conversion of perindopril perindoprilat , Which accordingly reduces its bioavailability. Excreted through the kidneys do not cumulate.
Indications
From what Perineva pills? Perineva drug is prescribed in the following cases:
- prevention of recurrent stroke (complex therapy in conjunction with indapamide );
- congestive heart failure ;
- arterial hypertension ;
- stable ischemic heart disease .
Contraindications
The drug should not be taken if:
- sensitivity to any component of the formulation;
- malabsorption syndrome glucose / galactose ;
- age 18 years;
- lactase deficiency ;
- anginevrotichesky swelling history (angioedema, idiopathic or hereditary swelling as a result of receiving ACE inhibitors);
- galactose intolerance .
Be wary if the drug is used:
- bilateral renal artery stenosis ;
- chronic renal failure ;
- renovascular hypertension ;
- artery stenosis of a solitary kidney ;
- decompensated heart failure ;
- hyponatremia, hypovolemia ;
- hyperkalemia ;
- cerebrovascular diseases ;
- hypertrophic obstructive cardiomyopathy ;
- after kidney transplantation;
- connective tissue diseases ;
- general anesthesia;
- diabetes ;
- in old age.
Side effects
As a result of taking the drug Perineva may experience the following side effects:
- paresthesia . dizziness . headache ;
- noise in ears;
- blurred vision;
- a significant reduction in blood pressure, angina . Arrhythmia . stroke . myocardial infarction . vasculitis ;
- breathlessness , Bronchospasm, coughing, rhinitis . eosinophilic pneumonia ;
- abdominal pain, nausea, dysgeusia, vomiting . constipation . diarrhea . dyspepsia , Dry mouth, pancreatitis . cholestatic or cytolytic hepatitis ;
- itch , Swelling of the extremities, face, skin rashes, hives . mulformnaya erythema ;
- muscle cramps;
- impotence . renal failure ;
- increased sweating, asthenia ;
- decrease in hemoglobin and hematocrit neutropenia . leukopenia . thrombocytopenia . pancytopenia . agranulocytosis (shown in use in a high dose for a long period of time) hemolytic anemia (rarely seen in patients with deficiency of glucose-6-phosphate dehydrogenase);
- increased concentration of urea and creatinine, hyperkalemia (reversible after discontinuation of the drug) hypoglycemia , Increased activity of hepatic enzymes.
Instructions for use Perinevy (method and dosage)
The drug should be one time, morning, orally before a meal.
The instructions tablets noted that the dose selected for an individual patient, depending on the severity of disease and response to therapy.
At hypertension Perineva medicine can be used as monotherapy or concomitantly with other drugs to lower blood pressure. The initial daily dose should not exceed 4 mg. If therapy for a month not successful, the dose can be increased to 8 mg (when normal transfer of the previous dose).
Before you start taking this medicine, you need at least 3 days to stop taking diuretics as concomitant use of these drugs can lead to hypotension.
Elderly patients is not recommended at the beginning of the course taken daily dose greater than 2 mg. If necessary during normal tolerance can be increased to 4 mg, and then to 8 mg.
At chronic heart failure you need to take the drug only under medical supervision, should start with the lowest dose (2 mg). Increased to 4 mg dose can be no earlier than a week.
As prophylactic of recurrent stroke dose to start is 2 mg. Start taking the drug can be in two weeks after suffering a stroke.
The recommended dose CHD is 4 mg. When monitoring of renal function after two weeks the dose may be increased to twice (8mg).
At kidney disease the dose is prescribed individually, based on the diagnosis and extent of violations. It is necessary to constantly monitor the condition of the patient, and the particular level of creatinine and potassium ions in blood.
Adjust dose at liver diseases required.
Overdose
In case of overdose, the patient may experience the following symptoms: shock, renal failure . bradycardia , A sharp decrease in blood pressure, hyponatremia , Dizziness, cough, hyperkalemia . tachycardia , Anxiety, hyperventilation , Palpitations.
With a sharp decrease in blood pressure the patient should take the prone position, legs slightly raised, as it is necessary to take measures to fill the bcc. If bradycardia That is refractory to therapy (in particular, antropinic ), You must install pacemaker (artificial pacemaker). Perindopril from blood can be removed by hemodialysis.
Cooperation
Simultaneous with the adoption Perinevy diuretics It may lead to hypotension. Reduce the risk of its occurrence is possible by the abolition of diuretics or to take the drug at lower doses. In the future, increasing the dose Perinevy should be administered with caution.
The combination of perindopril potassium-sparing diuretics . products and additives , and potassium supplements It can lead to hyperkalemia. Assign them to be exclusively at hypokalemia with the utmost care, while controlling the level of ions.
Perindopril together with lithium preparations It can cause lithium toxicity and enhance the level of lithium in the blood, so it is not recommended to assign them simultaneously. If necessary, such a combination should monitor the concentration of lithium in the blood.
Reduction of the antihypertensive effect may occur as a result of the combination with Perinevy NSAIDs . As such therapy can lead to a deterioration of the kidneys. In some cases, this may lead to acute renal failure.
Strengthen the antihypertensive effect of perindopril can simultaneously taking other agents that lower the pressure, or vasodilators .
Gipoklikemicheskie funds (including insulin ) And Perineva a joint application may cause increased hypoglycemic effect until glucose.
Sympathomimetics oslavlyayut therapeutic effect of perindopril, in their appointment is necessary to monitor the effectiveness of Perinevy.
Strengthen the anti-hypertensive effect may be antidipressanty . neuroleptics and general anesthetics .
Can be combined with Perinevy nitrates . antsetilsalitsilovoy acid . beta-blockers and thrombolytic agents .
Terms of sale
Prescription.
Storage conditions
In a dark place at 25 ° C.
Shelf life
3 years.
Cautions
Perindopril is not recommended at the same time lithium preparations . potassium-sparing diuretics and potassium-containing drugs . products and additives .
At diabetes first 3 months of Perinevy patients should monitor the level of glucose in the blood.
When driving a car should consider the risk of side effects such as dizziness and a sharp decrease in pressure.
Analogs Perinevy
Monopril
Renitek
Charter
Fozikard
Amprilan
Ramipril
Perindopril
Prestarium
Capoten
Berlipril
Akkupro
Diroton
Enap
Enalapril
Analogs of this drug are the following products: arentopres . gipernik . kovereks . parnavel . perinpress . perindopril .
Reviews Perineve
Among patients feedback on this medicinal product is quite contradictory. On one hand, many note its effectiveness, on the other - the effect from taking medication port side effects, including dizziness and coughing.
Price Perinevy
Cost tablets in Russian depending on the packaging of RUB 220 (4 mg), 330 rubles (8 mg). In Ukraine, the price of 8 mg - 180 UAH., 4 mg - 130 UAH.
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