Trifas

Description overdue on 11/17/2014

• Latin name: Trifas
• ATC code: C03CA04
• Active substance: Torasemide
• Manufacturer: Berlin-Chemie AG (Menarini Group), Germany

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Tablets Trifas, instructions for use
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

Tablets Trifas (Trifas 10) include 10 mg torasemide - Active substance.

Additional ingredients:

• fumed silica;
• lactose monohydrate;
• magnesium stearate;
• corn starch.

Product form

Trifas 10mg available in tablet form from 30, 50 or 100 pieces in one pack.

Pharmacological action

Diuretic.

Pharmacodynamics and pharmacokinetics

Torasemide It refers to the group saluretics Whose action is inhibition renal reabsorption   ions Chlorine and sodium Upstream knee loop of Henle . It has fast diuretic action   After the inner and / in use, which reaches its maximum at 2-3 hours and is effective for almost 12 hours. Diuretic action is quite strong and is celebrated even in cases where other diuretics ineffective. Torasemide eliminating the edema, with Heart Failure   reduces symptoms of the disease and has beneficial effects on the function infarction By means of pre- and afterload reduction.

When an internal reception shows antihypertensive action That develops slowly and is at the most effective for 3 months. Antihypertensive Trifasa efficiency is achieved by lowering PR   due to the normalization of previously impaired electrolyte balance   and substantially lowering activity in the muscles of the arteries of free Ca2 +. It is known that torasemide reduces susceptibility to internal vessels vasopressor Substances such as catecholamines .

Suction torasemide after internal reception complete, rapid and extends over 60-120 minutes, regardless of the meal.

Bioavailability - 80-90% of the plasma protein binding of about 99%.

The end products of the transformation - metabolite M1, M3 (active) and M5 (inactive).

Kinetics of torasemide and its metabolites are characterized by linear, that is, Cmax in plasma and AUC increases in accordance with the highest dose.

T½ in healthy volunteers was equal to 3-4 hours.

Renal clearance   about 10 ml / min total clearance   - 40 ml / min.

Displays 80% of the urine, bile otherwise.

Availability renal failure   almost no effect on T½ and Total clearance of torasemide.

Indications

The drug is used in therapy Trifas essential hypertension As well as in the prophylaxis or treatment of relapsed effusions and / or edema That developed because Heart Failure .

Contraindications

• hypovolemia ;
• hypersensitivity   to Torasemide Trifasa or other ingredients;
• with renal insufficiency anuriei ;
• hyponatremia ;
• hypotension ;
• state hepatic coma   or prekomatosnoe;
• hypokalemia ;
• expressed pathology system micturition , such as prostatauxe ;
• children's age;
• during breast feeding.

Side effects

• itch skin, photosensitization . eczema ;
• anemia . leukopenia . thrombocytopenia ;
• predisposition to thrombosis . hypotension ;
• metabolic alkalosis , Hypovolemia, hypokalemia, hypomagnesemia, hyperlipidemia, hyperglycemia, hyperuricemia;
• azotemia , Acute urinary retention;
• dryness of the mouth, pancreatitis , Weakening appetite, diarrhea . vomiting , Elevated liver enzymes, constipation ;
• paresthesia . headache , Feeling of weakness, feeling sleepiness . dizziness , Confusion, convulsions ;
• visual impairment , noise in ears, deafness .

Tablets Trifas, instructions for use

Trifas in the form of tablets taken orally (po), one tablet can be divided into two or four parts.

With essential hypertension , Instructions for use Trifas 10 mg recommends to start with a quarter pill (2, 5 mg) per day. Due to the fact that the action of the drug is gradually, and the maximum efficiency is observed only after 3 months, this dose should be taken during this period. After 3 months, in the case of lack of effectiveness of reduction BP Dose can be increased twice Trifasa (5 mg). Also, the dose of 5 mg is recommended as the initial failure at renal function   or severe hypertension . A further increase in dosage is not appropriate and can take place only after consultation with your doctor.

With effusions and / or edema therapy should be initiated with 5 mg per day Trifasa (half tablets). In severe cases, the dosage may be increased torasemide Up to 20 mg per day.

Overdose

In case of overdose observed an increase diuresis In this connection, the possible development of dehydration violations electrolyte metabolism . Also exhibit drowsiness , Impaired consciousness, cardiovascular failure Symptomatic hypotension . dyspeptic violations.

Typically, symptoms intoxication runs alone at low doses Trifasa or its abolition. Displaying holding infusion therapy   to adjust electrolyte balance . Hemodialysis It does not output Torasemide from blood.

Cooperation

Admission Trifasa enhances the effects of other antihypertensive means, including ACE inhibitors .

In parallel with taking drugs digitalis ( Digoxin ) shortcoming Potassium It caused torasemide can cause increased side effects of both drugs.

Action antidiabetic funds may be reduced when taking torasemide .

NSAIDs and Probenecid lower diuretic and as a consequence hypotensive action.

Perhaps greater toxic effect salicylates When co-administered with Trifasom.

Torasemide, especially in high doses, leads to increased Oto-and nephrotoxicity cytostatics and antibiotics aminoglycoside series ( kanamycin . Tobramycin . Gentamicin ) And nephrotoxicity cephalosporins .

Laxatives, glucocorticoids and mineralocorticoid , When combined with the admission Trifasom, increase potassium loss.

Treatment with Trifasa may enhance the effects of curariform relaxants   and Theophylline .

At the same time pursued therapy preparations lithium It can increase its concentration in blood.

Torasemide may reduce the vasoconstrictor effect catecholamines ( Epinephrine . Norepinephrine ).

Kolestiramin It reduces the absorption of torasemide and thus its effectiveness.

Terms of sale

To purchase Trifasa in the pharmacy requires a prescription.

Storage conditions

The preparation can be stored at room temperature, away from children and sunlight.

Shelf life

5 years.

Cautions

Trifasom therapy should be under constant monitoring electrolyte balance , including Potassium in plasma. Also, it is necessary to control the levels of Uric acid . Glucose . lipids and creatinine .

With diabetes   We need to monitor the metabolism of carbohydrates.

There should be regular evaluation of the blood picture (content erythrocyte . leukocytes . Platelet ), As well as to monitor the symptoms of blood clots and loss electrolytes , Particularly for elderly patients.

It is not necessary to prescribe medication use torasemide at arrhythmias . anemia , Disorders of acid-base balance, gout . thrombocytopenia .

Analogs

Match code ATC 4th level:

• Diuver
• Lasix
• Furosemide

If you can not find Trifas in the free market, you can buy its analogs. In Russia, these drugs are:

• Torasemide Canon;
• Britomar;
• Trigrim;
• Diuver;
• Furosemide.

Babies

Trifas, due to the lack of experience of application, do not prescribe in childhood.

During pregnancy (and lactation)

Do not use this during Trifasa Lactation .

During pregnancy It can be administered only in extreme cases, under strict control and in minimal doses.

Reviews Trifas

In the circle of doctors applying loop diuretics , Drug Trifas gets positive reviews and is the drug of choice. According to many studies of its use can not only increase the effectiveness of diuretic therapy, but also to avoid the serious complications associated with its purpose. Trifas has a less pronounced effect on the excretion of potassium, magnesium, calcium, etc., And greater efficiency in comparison with Furosemide Easier tolerated in elderly patients and patients with heart and other diseases.

Among the reviews of patients can be met and a negative opinion about the effectiveness of Trifasa. You can often read complaints of not passing swelling or insufficient diuretic effect. Recall that the action of torasemide develops gradually improved and disease states can be seen, most often a month or two of continuous use.

Price Trifasa where to buy

In Ukraine, the price Trifas 10 mg on average №30 - 160 hryvnia; №50 - 200 hryvnia; №100 - 270 hryvnia.

The average price in rubles, not including delivery in Russia is 1,400 rubles for 30 tablets.

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