Betalok

Description overdue on 07/16/2014

• Latin name: Betaloc
• ATC code: C07AB02
• Active substance: Metoprolol tartrate (Metoprolol tartrate)
• Manufacturer: AstraZeneca AB (Sweden)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use betalok
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

In addition to the main active ingredient ( metoprolol tartrate ), The drug contains the following subcomponents:

• Solution for internal administration : sodium chloride Water.
• Pills : lactose monohydrate . sodium carboxymethyl starch . povidone . magnesium stearate . anhydrous colloidal   silicon dioxide .

Product form

• Solution for internal administration It is a colorless transparent liquid.
• White pills   They are in a plastic bottle (for 100 pcs.), placed in a cardboard box.

Pharmacological action

Renders antiarrhythmic . antianginalnoe   and hypotensive action .

Pharmacodynamics and pharmacokinetics

Metoprolol significantly reduces or completely eliminates the influence catecholamines   at Mental . physical   and emotional voltage . Furthermore, it moderately reduces heart rate, and myocardial contractility . It has hypotensive effect.

Betalok may slightly increase the level of triglycerides and reduce the concentration of free fatty acids in serum. In some cases, significantly reduced the level of Lipoprotein   high density.

The solution at betalok myocardial infarction   It helps reduce the severity of pain, as well as reduce the risk of ventricular fibrillation   and atrial fibrillation . In the early period of myocardial helps limit the affected area and spread Necrosis .

Betalok solution spreads rapidly, within a few minutes. At a dose of 20 mg of linear pharmacokinetics. The half-life of 3-4 hours on average. Absorbs 95% of the remaining substance excreted unchanged.

Indications

Indications Tablets:

• arterial hypertension ;
• irregular heartbeat;
• problems with the heart, accompanied by tachycardia ;
• angina pectoris I .

As part of the complex therapy prescribed for hyperthyroidism   and after myocardial infarction . Can be used to prevent attacks migraine .

Indications for use of the solution:

• tachycardia ;
• myocardial ischemia ;
• pain during myocardial infarction   or suspected it.

It can also be used for prophylaxis tachycardia   and myocardial ischemia .

Contraindications

Tablets and betalok solution should not be taken if you are hypersensitive to the drug, and other beta-blockers And when:

• atrioventricular block   II and III level;
• clinically significant sinus bradycardia ;
• sick sinus syndrome;
• hypotension ;
• Heart Failure   in dekompensatsionnoy stage;
• cardiogenic shock ;
• expressed infringement peripheral circulation ;
• Acute myocardial infarction   with a heart rate of 45 beats / min or less, systolic blood pressure less than 100 mm Hg. v., and from the PQ interval is greater than 0, 24 seconds;
• severe peripheral vascular disease (in the case of threat gangrene ).

In addition, the tool can not make those who receive inotropic   agents and stimulants beta-adrenergic receptors   periodically or continuously.

With caution should be used when Betalok I degree atrioventricular block . COPD , Heavy renal failure . Prinzmetal angina . diabetes . For children, the efficacy and safety of the tool is not set.

Furthermore, a solution for injection should be avoided in the treatment of supraventricular tachycardia . if the arterial pressure is less than 110 mm Hg, and tablets - patients receiving intermittent   long-term therapy inotropic drugs that affect beta-adrenergic receptors .

Side effects

When using betalok side effects are usually mild or reversible.

The studies identified the following possible side effects:

• by Cardiovascular : Cold extremities, bradycardia , Fainting, palpitations, cardiogenic shock   (happens with the treating acute myocardial infarction ) atrioventricular block   degree I and all sorts of other cardiac conduction disorders;
• by GI : nausea . diarrhea , Abdominal pain, constipation . vomiting ;
• by skin Rash, excessive sweating;
• by Metabolism : An increase in body fat;
• by CNS : Fatigue, headache . paresthesia I . depression . drowsiness . convulsions . dizziness , Weakening of attention, insomnia   or nightmares;
• by Respiratory : Appearance shortness of breath during exercise, bronchospasm .

In rare cases arrhythmia . gangrene , Increased nervous irritability, impotence / sexual dysfunction , Anxiety, impaired memory, hallucinations , Depression, dry mouth.

Some patients also noted violations of the liver, hepatitis , hair loss, photosensitization , Worsening psoriasis . rhinitis , Blurred vision, conjunctivitis , Eye irritation, tinnitus, taste disturbance, arthralgia . thrombocytopenia .

Instructions for use betalok

Instructions for use as a solution betalok its introduction only provides medical professionals with appropriate skills and the conditions required for resuscitation.

With supraventricular tachycardia   initial dose - 5 mg (5 mL). The rate of introduction - 1-2 mg / min. Applied every 5 minutes until the desired effect (usually it takes 10-15 mg sodium). But it should not be given more than 20 mg.

With myocardial infarction , Prevention and treatment of myocardial ischemia . tachycardia is administered 5 mg (5 ml) solution every 2 minutes before the onset of the effect, but should not exceed 15 mg dose (15 ml). After a quarter of an hour after the last injection therapy should continue the use of oral metoprolol (50 mg every 6 hours for two days).

If appointed to take pills Betalok, instructions for use provide different dosages for different occasions:

• arterial hypertension : 100-200 mg administered one time sutra or in two (in the morning and evening), if necessary, the dose can be increased or add another antihypertensive   medication;
• cardiac arrhythmia : It is necessary to appoint 100-200 mg per day in 2 divided doses (in the morning and evening), if necessary, can add another antiarrhythmic   medication;
• disorders of the heart in tachycardia : 100 mg administered one time per day (preferably in the morning), if necessary, the dose can be increased;
• hyperthyroidism : Appoint 150-200 mg per day in 3-4 hours;
• angina : 100-200 mg administered daily for 2 doses (in the morning and evening), if necessary, can add another antianginal medication;
• maintenance therapy after suffering myocardial infarction : It is necessary to appoint a 200 mg daily for two doses in the morning and evening;
• prevention migraine : Appoint 100-200 mg per day in 2 divided doses (in the morning and evening).

Pills taken by mouth during a meal or on an empty stomach.

Overdose

Application betalok solution in dose of 7, 5 g may lead to toxicity with a lethal outcome. Doses of 1, 2 and 4 g, 5 g caused respectively moderate and severe intoxication.

When possible overdose bradycardia . asystole . perfusion   weak peripheral, atrioventricular block   I-III degree, marked reduction in blood pressure, cardiogenic shock , heart failure. From the light there is difficulty in breathing, apnea . CNS there is increased fatigue, loss and impaired consciousness. In addition, you may receive tremor , Increased sweating, spasms . vomiting . hypo-   or hyperglycemia . transient myasthenic syndrome . seizures . paresthesias . nausea . hyperkalemia .

The first signs of drug overdose observed after 20-120 minutes after administration.

As treatment is assigned to the activated carbon and / or gastric lavage. Moreover, symptomatic treatment. So if necessary, the intubation and adequate ventilation, ECG monitoring, replenishing BCC and glucose infusion, administered atropine . When suppression infarction   introduced dobutamine   or dopamine . It may also be used glucagon   50-150 mg / kg intravenously every minute until the effect. In some cases use adrenaline . When Arrhythmia   and an increase in the ventricular complex, a solution of sodium. You can use an artificial pacemaker. To prevent bronchospasm   used terbutaline . And when you stop the heart held resuscitation.

With an overdose of pills Betalok be such consequences sinus bradycardia . vomiting   or nausea . atrioventricular block . bronchospasm . coma , Heavy hypotension . cardiogenic shock , Heart failure, heart failure, impaired consciousness, cyanosis .

Treatment is symptomatic. Typically, prescribed Activated carbon   and gastric lavage.

With a significant reduction in blood pressure, bradycardia   and heart failure is administered stimulants beta1-adrenoceptor   (every 3-5 minutes until the result). Also appointed dopamine   and Atropine Sulfate . sympatholytics   ( norepinephrine . dobutamine ) And glucagon at a dosage of 1-10 mg. You can use the driver's heart rate.

When used intravenously bronchospasm stimulants beta2-adrenergic receptors.

Cooperation

In a joint application with betalok ganglioblokatorami Blockers beta-receptor   and MAO inhibitors   you need to carefully monitor the patient's condition.

If you cancel clonidine Received in the background betalok last canceled a few days before.

In addition, the drug can not be combined with verapamil   and a number of other antiarrhythmic agents and calcium antagonists barbiturates . propafenone . Inhaled anesthetics   in conjunction with the offer betalok potentiation cardiodepressive action .

Inductors   and inhibitors   metabolism affect the plasma concentrations betalok. And his   hypotensive action reduced when combined with inhibitors   synthesis prostaglandin .

Terms of sale

Betalok sold strictly on prescription.

Storage conditions

Store this medication in a well-protected from light place at a temperature below 25 ° C.

Shelf life

Store this medication can be no more than 5 years.

Analogs betalok

Match code ATC 4th level:

• Nebivolol
• Biprol
• Bisoprol
• Concor Cor
• Lokren
• Concor
• Niperten
• Betaloc ZOK
• Coronal
• Egilok
• Nebilet
• Atenolol
• Metoprolol

In drugstores such analogs betalok as:

• Azoprol Retard ;
• Vazokardin ;
• Egilok Retard .
• Korvitol ;
• Metokor ;
• Betaloc ZOK ;
• Metoprolol ;
• Metoprolol Zentiva ;
• Metoprolol tartrate.

Betaloc ZOK   It belongs to the same manufacturer and are usually self Betalok compared with it.

What is different from the Betaloc ZOK betalok?

The forums are often asked the question: what is different Betaloc ZOK   by betalok. Experts explain that in the first case, the drug does not act immediately. Active substances are allocated gradually, and therefore better tolerated preparation is different. Its side effects are less pronounced. Both drugs, however - and Betalok Betaloc ZOK   - Strictly dispensed in pharmacies by prescription.

Reviews betalok

Reviews betalok are generally positive, it is well tolerated by most patients. Some, however, note the general deterioration of the appearance of weakness and irritability. Despite the occurrence of side effects, drug effect.

Price betalok where to buy

Price betalok tablets on average 450 rubles. Despite the fact that it has a much cheaper analogues, the drug is popular due to its effectiveness.

Price betalok as a solution for injection is even higher - about 800 rubles.

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