Description overdue on 11/11/2014
- Latin name: Amigrenin
- ATC code: N02CC01
- Active substance: Sumatriptan (Sumatriptan)
- Manufacturer: OAO Veropharm, Russia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Amigrenin (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- During pregnancy (and lactation)
- Analogs
- Reviews
- Price, where to buy
Composition
The composition of the tablets: 50 or 100 mg sumatriptan ( sumatriptan succinate ) + Additional ingredients (microcrystalline cellulose, potato starch, magnesium stearate, hypromellose, macrogol, titanium dioxide, talc, lactose, carboxymethylstarch sodium, povidone, polyethylene glycol 4000).
Product form
The drug is released in the form of white or slightly grayish round tablets, biconvex shape. If you split the tablet in half, you can clearly see the two layers. Internal - white or yellowish, appearance - the color of the shell. The drug release in two doses of 50 or 100 mg in blisters on 2 pieces each. In a cardboard bundle two tablets of the drug.
Pharmacological action
Protivomigrenoznoe .
Pharmacodynamics and pharmacokinetics
Sumatriptan It constricts blood vessels of the brain by interacting with 5-HT1-receptors in the brain. It is noteworthy that the material does not affect 5-HT2 - 5-HT7- receptors . Serotonin 5-HT1D-receptor It is also involved in the mechanism of action of the drug, however, in a polling manner. Thereby, system It is not activated, and specific stimulatory protein kernels Trigeminal It does not accumulate. Vessels that during a migraine attack has been extended, narrowed, the attack stops. Direct analgesic effect does not have the means.
intranasal the application of the active ingredient means of rapidly absorbed into the systemic circulation. When administered intranasally this occurs after 1, 5 hours.
The drug has a low degree of binding to plasma proteins, about 17%, its biotransformation in the body taking part MAO . The major metabolite sumatriptan - him glucuronide . Withdrawal of the drug through the kidneys and GI .
Improvements in the patient begin to occur in half an hour after administration of 100 mg of the means and 15 minutes after intranasal administration.
Within one day after the onset of dosing and relapses may occur in this connection means reused.
Indications
The drug is prescribed for relief of attacks migraine Originating Wrath or without Aura .
Contraindications
The drug is contraindicated:
- pregnant and lactating women;
- at hemiplegic migraine ;
- oftalmoplegicheskoy migraine ;
- basilar migraine ;
- at stroke
- at ischemia ;
- adolescents and the elderly;
- in case of serious liver disease;
- at epilepsy ;
- allergies on the components of the means;
- at transient ischemic attacks ;
- when taking drugs is not combined with Amigrenin example MAO inhibitors . ergotamine (see. lek. Interactions).
Side effects
Side effects from the : Pressure reduction, tachycardia and angina , Palpitations, increased Blood Pressure . bradycardia . ischemia . Very rarely possible Raynaud's syndrome .
allergy ( hives , Skin rashes or itching).
Side effects from the ZHTK Vomiting, indigestion, pain in the stomach, nausea. Rarely ischemic colitis or raising Hepatic transmiaz .
On the side Nervous System may occur: weakness, drowsiness, blurred vision, apathy.
It is also observed: sensation of warmth, compression, tingling or heaviness, pain in the muscles.
Instructions on Amigrenin (method and dosage)
The medicine can only be used for sudden attacks migraine As a means of emergency.
: The drug is prescribed for adults. The maximum amount per day - 300 mg. As a general rule, appoint 50 or 100 mg at one time.
If after some time the symptoms resumed, then another dose may be taken no earlier than 2 hours, but no later than one day after the original.
If the drug does not bring relief condition should consult a doctor and take other medicines.
Overdose
If an overdose of the drug, should be carried out symptomatically. Wherein hemodialysis It is not effective against an overdose. The clinician should observe the condition of the patient within 10 hours after ingestion.
Cooperation
The preparation pharmacologically incompatible with MAO inhibitors .
The combination of funds from ergotamine It can lead to the permanent vascular spasm.
Simultaneous reception Antidepressants and increases the risk of Amigrenin hyperreflexia , Impaired coordination of movements and asthenia .
The drug increases the toxicity and lithium preparations .
It is not recommended to combine the drug with selegiline .
Terms of sale
In order to buy medicine, require a prescription.
Storage conditions
Shelf life
2 years.
Cautions
Particular caution should be exercised when administering the drug epileptics At a controlled hypertension or people with reduced seizure activity.
To avoid spasm coronary artery Cardiovascular system, the first receiving the drug should be done under medical supervision.
With increased sensitivity to sulfonamides , Severe allergic reactions are possible. The drug is not recommended to assign.
There are no pharmacokinetic especially in patients older than 65 years have been identified.
Due to the high risk of drowsiness when receiving funds, it is advisable to refrain from driving or performing activities that require high concentration and speed of reaction.
During pregnancy and lactation
Use of the drug during pregnancy and breastfeeding is prohibited.
Analogs Amigrenin
Sumatriptan
The closest analogues: Sumitran, Imigran, Rapimed, Sumamik, sumatriptan, Sumig, Trimigren, Migrepam, sumamigren, Sumarin, Zomig .
The forums on the Internet has a lot of good reviews Amigrenin. The drug helps to quickly and eliminates the agonizing migraine headaches . Sometimes side effects occur, but patients still continued to take the drug, since, in their opinion, it is the only way to avoid attacks.
Price Amigrenin
Price Amigrenin - about 155 rubles for 2 tablets of 50 mg.
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