Ksefokam

Description overdue on 21.10.2012

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NSAIDs . Active Ingredient - lornoxicam . The basic substance is classified as oxicams. The drug Ksefokam has analgesic, anti-inflammatory, antipyretic and antiplatelet effects. The mechanism of the main impact is directed to the suppression of pro-inflammatory factors, metabolic disorder arachidonic acid , Inhibition of cyclooxygenase-1, 2, reduced platelet aggregation, reduced production prostaglandins   in inflammatory foci in healthy organs and tissues, suppression of the proliferative phase of the inflammatory and exudative process. Ksefokam available in tablet dosage form, and FIDE lyophilizate.

Indications:

Ksefokam prescribed for ankylosing spondylitis, osteoarthritis, rheumatoid arthritis , Tenosynovitis, bursitis. The drug is used in gout exacerbation (articular form), with pain syndrome: headache, sciatica, lumbago Neuralgia, myalgia, arthralgia, burns, injuries, algodismenoree, headache, toothache, when feverish syndrome , Followed by infectious and respiratory diseases.

Contraindications:

Ksefokam does not apply to erosive and ulcerative lesions of the digestive system ( ulcerative colitis , Peptic ulcer disease), intolerance to drugs of the NSAID, with bleeding in the brain, lack of glucose-6-phosphate dehydrogenase, renal failure , Liver failure, breastfeeding, pregnancy. After surgery, with moderate renal failure, bleeding from the digestive system and erosive and ulcerative lesions of the history Ksefokam used with caution.

Side effects, overdose:

The digestive tract:   epigastric pain, heartburn , Vomiting, nausea, dry mouth, dyspepsia, abnormalities in liver function, NSAID-gastropathy as erosive ulcers, gastritis, esophagitis . Nervous system:   agitation, drowsiness, dizziness, headache, aseptic meningitis Tremor, depression, sleep disorders. Subcutaneous fat, the skin: puffiness. Urinary system:   acute renal failure, peripheral edema , Nephrotic syndrome, papillary necrosis, glomerulonephritis, interstitial nephritis, and violation of the reduction of glomerular filtration, dysuria. Senses:   periodic tinnitus. Cardiovascular system:   increase in blood pressure, tachycardia, worsening or development Heart Failure . Bodies of hematopoiesis, hemostasis system:   thrombocytopenia, anemia, leukopenia, agranulocytosis . Local reactions:   painful reaction at the injection site, flushing of the skin. Also, a change in body weight, sweating, angioedema . hives . itching , Rash. In case of overdose observed acute renal failure, increased severity of the above adverse reactions from the digestive system, nervous system. Requires gastric lavage, posindromnaya therapy, reception activated carbon adsorbents. Dialysis   not proved effective.

Mode of application:

Ksefokam taken before meals, preferably drinking plenty of fluids. When pain syndrome of moderate to severe pronounced appoint 8-16 mg, in the future, if necessary, an additional medication administered at a dose of 16 mg in the first 24 hours, then move on to receive 8 mg twice daily. Adults with inflammatory processes prescribed initial dose of 12 mg, and then move on to receive 8-16 mg 2-3 times daily. At night you can take no more than 16 mg. Powder Xefocam before administration diluted in 2 ml of water for injection. The drug is administered intravenously over 15 seconds, or intramuscularly for 5 seconds. The initial dose is 8-16 mg, more times per day to 8 mg. The daily dosage in the pathology of the renal system, liver diseases, disorders of the digestive tract and the elderly is 12 mg (3 doses).

Special instructions:

Ksefokam drug therapy requires regular monitoring over the work of the digestive system due to the risk of gastrointestinal bleeding, ulcerogenic effects . It is recommended to assign a synthetic prostaglandin analogs such as misoprostol, histamine receptor blockers, omeprazole. During treatment requires monitoring of liver function, renal system, peripheral blood. Patients with kidney disease require correction mode, dynamic monitoring. Ksefokam retards lithium ions, potassium, sodium and water in the body worsens heart failure, arterial hypertension. Ksefokam Rapid affect the management of vehicles, concentration.

Drug Interactions:

Ksefokam improves antiplatelet agents , Anticoagulants, fibrinolytic agents, reduces the effectiveness of uricosuric medications . The drug usblivaet severity of side effects estrogen , Corticosteroids, diuretics , Antihypertensive drugs, ISS. The drug increases the severity of hypoglycemic effects of sulfonylureas. Ksefokam Rapid is able to reduce the renal clearance of digoxin. The drug increases the concentration Methotrexate   blood preparations lithium. Cimetidine increases the concentration of drug in the blood. Gematotoksichnosti   the drug is enhanced by the appointment of myelotoxic agents. Kolestiramin , Antacids may reduce absorption of lornoxicam.