Description overdue on 07/08/2014
- Latin name: Depakine Chronospere
- ATC code: N03AG01
- Active substance: Valproic acid (Valproic acid)
- Manufacturer: Sanofi-Aventis France (France)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Depakine Chronosphere
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Reviews
- Price, where to buy
Composition
Depakine Chronosphere is composed of the following active ingredients: valproic acid . sodium valproate .
Supporting components of the preparation: solid paraffin . aqueous colloidal silica . glycerol dibehenate .
Product form
The drug is available in the granules.
Pharmacological action
Protivoepileptichesy drug.
Pharmacodynamics and pharmacokinetics
Depakine Chronosphere is an antiepileptic drug that has sedative And central miorelaksiruyuschee action . Active substance affects drug GABAergic system . This increases the concentration of GABA (gamma-aminobutyric acid) in the central nervous system and activates GABAergic transmission .
The bioavailability of the drug in blood after oral administration of approximately 100%. It enters the brain and CSF . For the therapeutic effect the minimum drug concentration in blood serum - 40-50 mg / l. At a concentration of 200 mg / l is necessary to reduce the dosage. The maximum content in the blood plasma - approximately 7 hours.
Sustained concentration in plasma is formed by 3-4 day use. The high degree of connection with plasma proteins. The drug is mainly excreted in urine. Food intake has no effect on pharmacokinetics.
Indications
Adults are recommended to take Depakine Chronosphere for the treatment of:
- Bipolar affective disorder ;
- generalized seizures ;
- partial seizures .
Babies drug prescribed for the treatment of partial and generalized seizures .
In addition, it is used as a preventive agent at high temperature in order to avoid the appearance of convulsions if necessary.
Contraindications
The medicine should not be taken in case of hypersensitivity to its components, malfunctions of the pancreas, as well as hepatic insufficiency .
Side effects
During the application of Depakine Chronosphere may include the following side effects:
- genetic disorders : teratogenic risk ;
- by CNS : tremor limbs, drowsiness . ataxia ;
- by Hearing : Reversible and irreversible deafness;
- by GI : Pain epigastric , nausea, vomiting, diarrhea ;
- by skin : Transient and dose-dependent alopecia ;
- by immune system : allergic reactions . angioedema Syndrome, drug rash with eosinophilia ;
- by psyche Irritability, confusion, hyperactivity condition hallucinations ;
- by blood and lymphatic system : thrombocytopenia . agranulocytosis , Reducing the concentration fibrinogen in blood;
- by organs of vision : diplopia . nystagmus ;
- by genital : Male infertility;
- by Metabolism Isolated and reasonable ammoniemia ;
- common disorders: weight gain.
In addition, in rare cases, the drug can:
- pancytopenia ;
- leukopenia ;
- anemia ;
- disorders of bone marrow hematopoiesis;
- pancreatitis ;
- toxic epidermal necrolysis ;
- Stevens-Johnson syndrome ;
- erythema multiforme ;
- rash ;
- vasculitis ;
- amenorrhea ;
- dysmenorrhea ;
- extrapyramidal disorder;
- Dementia ;
- enuresis ;
- syndrome of inappropriate secretion of antidiuretic hormone;
- hyponatremia ;
- minor peripheral edema;
- liver disease;
- changes in behavior, mood;
- feeling tired;
- psychoses ;
- restlessness;
- depression ;
- aggressiveness;
- unusual excitement;
- ataxophemia .
Instructions for use Depakine Chronosphere
Instructions on Depakine Chronosphere includes receiving the drug inside while eating 2-3 times a day. At the same time it should drink plenty of water. The starting dose for adults and children who weigh more than 25 kg, - 5-15 mg per 1 kg of body weight per day. Gradually, it is possible to increase by 5-10 mg / kg per week. However, the maximum dose of the drug per day should not exceed 30 mg / kg.
Overdose
Overdose of the drug might lead to Coma Accompanied by muscle hypotonia . metabolic acidosis . hyporeflexia . respiratory depression . There are cases of intracranial hypertension and seizures. In general, the symptoms of an overdose may be different. At very high doses, and possible death.
As an emergency room do gastric lavage, supporting effective diuresis And supervise the functioning of the cardiovascular and respiratory systems. In some cases, effective use Hemodialysis and hemoperfusion .
Cooperation
The active substance Depakine Chronosphere activates other psychotropic drugs, while the application, so you need to adjust the dose if needed.
In addition, Depakine Chronosphere increases plasma concentrations of Phenobarbital . Primidone . Zidovudine with amplification of some effects, including sedation by Phenobarbital . The drug also reduces total plasma concentration Phenytoin .
Valproic Acid activates toxicity Carbamazepine and A amotridzhina . Preparations should be accepted together only under the strict supervision of a specialist. In addition, Depakine Chronosphere hinders metabolism Lamotrigine in the liver and increases its half-life period of almost 2-fold.
Valproic acid reduces the mean clearance Felbamata and enhances the hypotensive effect Nimodipine .
Antiepileptic drugs that induce hepatic microsomal enzymes, reduces the content of active ingredient Depakine Chronosphere plasma. The same effect has Felbamate when combined with the drug.
It is not advisable to combine Mefloquine and valproic acid Otherwise the probability of an epileptic seizure. Efficiency Depakine Chronosphere also be affected by simultaneous use of St. John's wort rifampicin . Its concentration conversely increases in combination with drugs that are known to high degree of binding to plasma proteins. The serum concentration of the drug also increases in the use of Cimetidine or Erythromycin .
Do not combine with Depakine Chronosphere Carbapenems and Topiramate . If this can not be avoided by the administration of drugs should be under strict medical supervision.
Ethanol and other potentially hepatotoxic drugs together with valproic acid increase hepatotoxic effects latter. And in combination with Clonazepam may increase symptoms Status of absence .
Myelotoxicity drugs when used together with Depakine Chronosphere increase the risk of suppression of bone marrow hematopoiesis.
Terms of sale
The drug is released strictly on prescription.
Storage conditions
Depakine Chronosphere should be stored in a dry, warm place. The temperature should be no higher than 25 ° C.
Shelf life
The shelf life of the preparation - 2 years.
Reviews of Depakine Chronosphere
Reviews of Depakine Chronosphere report on the effectiveness of the drug. This new form of Depakin, which enjoyed great success. Many parents are afraid of the unusual form of a known substance, but in this case should not be afraid. Babies this tool, you can also give. This is just a new form of treatment epilepsy Which allows the drug to facilitate young patients.
Many also point out that thanks to an improved form of Depakine Chronosphere very convenient to carry.
Price Depakine Chronosphere where to buy
Price Chronosphere Depakine 500 mg on average about 700 rubles. Other dosages do not differ much in value. So granules 250 mg can get at an average price of 670 rubles, and 750 mg granules are sold in about 930 rubles.
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