Description overdue on 08/22/2014
- Latin name: Triphtazinum
- ATC code: N05AB06
- Active substance: Trifluoperazine (Trifluoperazine)
- Manufacturer: JSC "Dalkhimpharm" (Russia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications triftazin
- Contraindications
- Side effects
- Triftazin, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
The chemical composition can vary depending on the form of. One tablet medicament contains 5 or 10 mg. trifluoperazina hydrochloride and excipients such as: aerosil, gelatin, refined sugar, wax, magnesium carbonate, potato starch, calcium stearate, talc, indigo carmine, titanium dioxide and polyvinylpyrrolidone.
In the 1 ml. Triftazine (0, 2% solution) contains 2 mg. the active drug substance.
Product form
The drug is produced in tablet form or as a solution, which is designed to intramuscular .
Having a lenticular shape pills Triftazin coated marble-blue color, containing 5 or 10 mg. trifluoperazina . Valium planimetric packaged in blisters 10 or 100 pcs., as well as polymeric jars of 50 pcs. in each.
The drug solution was packed in cartons for 5 or 10 vials (1 ml.) Each.
Pharmacological action
The drug belongs to the group neuroleptic , and antiemetics .
Pharmacodynamics and pharmacokinetics
The drug is a antipsihotropnoe means , Which includes a derivative phenothiazines . It actively acting neuroleptic drug affects CNS (central nervous system) . Under influence trifluoperazina going blocking postsynaptic mesolimbic brain .
This drug is superior in efficiency Hloropromazin and has an intensive antipsihotropnoe impact. In addition, the drug has alpha adrenoblokiruyuschey and anticholinergic activity And has pronounced antiemetic effect .
Triftazin quickly absorbed by the stomach. Its maximum concentration of the drug compound in blood plasma reaches several hours after intramuscular administration. The preparation metabolized by the liver And then eliminated from the body kidney As well as bile .
Indications triftazin
The main indications for use of the drug are the following diseases:
- schizophrenia ;
- psychomotor agitation;
- psychoses Including senile, involutional or alcohol;
- hallucinations;
- the heat of passion;
- delirium ;
- vomiting or nausea .
Contraindications
Do not use the drug if:
- hypersensitivity ;
- comatose states ;
- cardiovascular diseases ;
- states, CNS depression;
- blood diseases , and liver and kidneys ;
- beremennost and ;
- Children under 3 years of age;
- Lactation .
Precautions Triftazin used in the treatment of the elderly, and patients with alcohol intoxication , Suffering from cachexia . Reye's syndrome or Parkinson's disease, gastric ulcers, duodenal ulcers, breast cancer and epilepsy .
Side effects triftazin
Side effects of the drug are expressed in appearance:
- extrapyramidal disorders of the CNS;
- dyskinesia ;
- dystonic disorders;
- akatazii ;
- akinetorigidnyh manifestations ;
- autonomic disorders ;
- dizziness;
- fatigue ;
- blurred vision ;
- insomnia ;
- muscle weakness ;
- dry mouth ;
- Liver Diseases ;
- anorexia ;
- allergic reactions ;
- amenorrhea ;
- neuroleptic syndrome .
Triftazin, instructions for use (method and dosage)
According to the instructions triftazin tablet taken orally in the recommended dosage (maximum therapeutic) 40 mg. per day. The dosage as well as the medication schedule determines physician, considering in each case the state of health of the patient and the severity of whitening. To be most effective medication is best taken after a meal.
The dosage of the drug begin to gradually decrease after reaching the maximum effect of a therapeutic treatment. Typically, the initial dose for adult patients is 1 mg. twice a day. Usually the course of treatment is a maximum of 3 weeks.
The initial therapeutic dose for children aged 6 to 12 years is 1 mg. twice a day. If there is a medical need for a daily dose can be increased to a maximum of 4 mg. At treatment of children over the age of 12 years using a dosage equal to 5.6 mg. twice a day.
The recommended dose for adults with vomiting is 2 mg. per day. The initial dose for elderly patients should be reduced by half.
Overdose
Exceeding the recommended dose triftazin appear the following symptoms of overdose:
- reduction blood pressure;
- arefleksiya ;
- distortion visual perception ;
- arrhythmia ;
- shock ;
- hyperreflexia ;
- tachycardia ;
- ventricular fibrillation at ;
- agitation ;
- confusion ;
- drowsiness ;
- convulsions ;
- dry mouth ;
- disorientation ;
- respiratory depression ;
- hyperpyrexia ;
- muscle stiffness ;
- mydriasis ;
- hypothermia .
When the above-described side effects primarily used Triftazin stop and start symptomatic treatment.
Cooperation
To avoid severe depression and other Mental Disorders should not use the drug in conjunction with drugs that affect the central nervous system depressing. The risk of neuroleptic syndrome increases while taking this drug with monoamine oxidase inhibitors, antidepressants and maprotiline. Reduction seizure threshold possible when used in conjunction with Triftazin anticonvulsant drugs .
The increase in the severity and frequency of violations extrapyramidal nature , Increasing the risk of agranulocytosis appear at the same time taking triftazin and preparations causing extrapyramidal reactions, as well as for the treatment of hyperthyroidism .
Before the drug in conjunction with antihypertensive drugs may develop hypotension , from Ephedrine - Weakening its effectiveness, and to Prochlorperazine - Long loss of consciousness . Triftazin affect the force of the impact Guanethidine . amphetamines And, moreover, Clonidine .
Risk extrapyramidal complications may increase when combined with triftazin preparations containing lithium . This medicine may distort the display ototoxicity . In addition, it is not necessary to combine the drug with antacids That slow down absorption of the active drug substance.
Terms of sale
Exclusively by prescription.
Storage conditions
Since Triftazin refers to List B, the drug should be stored in a dark place and away from children.
Shelf life
The drug may not be used after a 3-year shelf life.
Cautions
When using triftazin recommended to continuously monitor the work kidney and liver As well as to conduct research analysis blood , Measure pulse and blood pressure . During the period of administration of the drug as possible to abstain from driving.
Analogs
By the same medicines include: Trazin, trifluoperazine-Apo, Triftazin-Darnitsa, Eskazin, Triftazin hydrochloride, L'Aquila, Vespezin, Flupirin, Kalmazin, Trifluperazin, Yatroneural and Vespezin.
Babies
Triftazin not recommended for use in the therapeutic treatment of children under the age of 3 years.
With alcohol
During treatment triftazin drinking alcohol is strictly forbidden.
During pregnancy (and lactation)
Do not take Triftazin without urgent medical need while pregnancy and lactation.
Reviews triftazin
Doctors about triftazin, however, as the patients are quite ambiguous, since they both say as a negative factor impressive list of side effects and contraindications of the drug.
Price triftazin where to buy
Average price triftazin (pack 50 tablets) does not exceed 50 rubles.
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