Legalon

Description overdue on 08/31/2014

• Latin name: Legalon70, Legalon 140
• ATC code: A05BA03
• Active substance: Milk Thistle fruit extract (Silybi mariani fructuum extract)
• Manufacturer: Madaus (Germany)

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• Composition
• Product form
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications legalon
• Contraindications
• Side effects
• Legalon - Instructions for use
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

• Legalon 70 1 capsule contains the active ingredient - dry extract of milk thistle fruits 86.5-93.35 mg, which corresponds to a content of 70 mg silymarin ; Excipients - povidone .   polysorbate 80 . mannitol . sodium carboxymethyl starch . magnesium stearate ; Capsule composition: gelatin, red oxide, titanium dioxide, sodium lauryl sulfate, black oxide.
• 1 capsule contains 173-188 Legalon 140, 7 mg   dry extract of milk thistle fruits , Which corresponds to 140 mg silymarin ; auxiliary substances and the composition of the capsule such as a capsule 70 Legalon.

Form release Legalon 70

• Solid gelatine capsules brown in 10 capsules in blister; in a cardboard bundle by 2, 3 or 6 blister (20, 30 or 60 capsules);
• pills 20 pills in a blister pack in a cardboard box.

Form release Legalon 140

• Solid gelatine capsules brown 10 capsules in blister; in a cardboard bundle 2, 3 or 6 blister (20, 30 or 60 capsules).

Pharmacological action

The product has the following pharmacological effects:

• hepatoprotective   - Protects the liver cells (hepatocytes) from destruction and toxic effects;
• regenerative   - Contributes to the regeneration of liver cells;
• detoxification   - It clears liver toxins, including free radicals (antioxidant effect);
• anti-inflammatory   - Inhibits inflammatory processes in the liver.

Pharmacodynamics and pharmacokinetics

Legalon - a herbal preparation, the active ingredient in it is a dry extract of milk thistle. The included fruit extract of milk thistle silymarin   - Is a vegetable Antioxidant   complex has a healthy effect on the liver. The milk thistle found a lot of biologically active substances, including several species silymarin   and isomer silymarin silibinin Providing hepatoprotective effect.

Action   silymarin   and its isomers based on their antioxidant properties. They inhibit lipid peroxidation, thus preventing the destruction of the membranes (membrane) of hepatocytes. Silymarin   promotes restoration of hepatocytes by enhancing the action of intracellular enzymes. It stimulates the formation of intracellular proteins and phospholipids, which are major components of cell membranes. Strengthening the membrane contributes to the preservation and rapid recovery of hepatocytes.

Silymarin   Prevent entry into hepatocytes some hepatotoxic poisons, such as poison mushroom pale toadstool. Furthermore, suppresses the formation of silymarin prostaglandins   - The main components of the inflammatory process, ie, has inflammatory action .

Recovery of cellular metabolism contribute contained in milk thistle fruit tocopherols, minerals (potassium, magnesium, copper, selenium), unsaturated fatty acid. Last actively promote oxidation cholesterol That prevents the spread of atherosclerosis .
Biologically active substances of milk thistle fruits also have positive effects on the gastrointestinal tract, the digestive processes and education bile .

After treatment Legalon   in patients with liver disease improves the general condition, including their less worried about weakness, pain in the right upper quadrant ,, vomiting, pruritus, appetite disorders, etc. At the same time improving and laboratory findings that say about the state of the liver.

Set the entire process of promotion legalon in humans is impossible, because it contains too many biologically active substances. But found that after administration Legalon   inside, its concentration in plasma reaches a maximum within half an hour.

The bulk of the drug is excreted in bile   in the form of metabolic products. Maximum excretion in the bile is reached after 2 hours. As a result of interaction with the intestinal microflora evolved with almost half of the bile silymarin   again absorbed in the intestine, forming the enterohepatic circulation.

Indications legalon

The drug is prescribed in the following diseases and conditions:

• after infectious or toxic hepatitis to, hepatic injury;
• at toxic (including alcohol), and drug-induced liver;
• chronic hepatitis   any origin;
• while the exchange-dystrophic diseases of the liver, including, when fat hepatosis ;
• at cirrhosis - Long-term use legalon slows the progression of cirrhosis;
• in diseases of the bile ducts and gall bladder of any origin;
• chronic   pancreatitis   and after acute pancreatitis;
• in disorders of fat metabolism, hyperlipoproteinemia and atherosclerosis   - Long-term use legalon inhibits the spread of these violations;

Contraindications for use legalon

Hypersensitivity to the drug

Side effects legalon

The drug is well tolerated. Because of side effects known to only a small legalon laxative effect Which is quite rare.

Legalon - Instructions for use

Capsules and pills taken by mouth, swallowed whole with water. Admission legalon not associate with eating. The dosage of the drug, the multiplicity of its reception during the day, the duration of treatment is determined by the attending physician, depending on the condition and age of the patient.

Instructions on Legalon 70 : Drug take 1 - 2 capsules twice or thrice a day. In the long course of treatment is sufficient to take the drug twice a day. Babies Depending on the age and general condition prescribed by half or one capsule three times a day. In the long course of treatment is sufficient to take the drug twice a day, at the same dosage.

Instructions for use Legalon 140 : Drug taking 1 capsule twice or thrice a day. In the long course of treatment is sufficient to take the drug twice a day.
The standard course of treatment - not less than 12 weeks, but can last several months.

Legalon Interaction with other drugs

The drug is perfectly combined with other drugs. But there is evidence that it is an antagonist of certain drugs, e.g., Yohimbine   (a treatment for Impotence ) And F entolamina (preparation of groups blockers expanding peripheral blood vessels).

Terms of sale

The drug is released at a pharmacy without a prescription.

Storage conditions

Capsules and pills should be stored in a dark place at a temperature no higher than 30 ° C. The drug should not be accessible to children.

Shelf life

5 years

Analogs

Match code ATC 4th level:

• Enerliv
• Laennek
• Progepar
• Antral
• Potassium Orotate
• Hepa-Merz
• Glutargin
• Phosphogliv
• Galstena
• Karsil
• Essentiale

Analogs - a variety of dosage formulations groups which are used to treat the same disease. Legalon belongs to the hepatic - drugs protects and restores the liver cells. He has many counterparts, both vegetable and animal, synthetic origin. There are also homeopathic remedies with hepatoprotective properties:

• vegetable hepatoprotectors - Apkosul, Liv 52;
• hepatoprotectors animal origin -   Syrepar Erbisol ;
• hepatoprotectors, which include essential phospholipids - Livolin forte, polyols, Liping, lipophile, Essentiale;
• hepatoprotectors containing amino acids - Ademetionine, Gepasteril B Glutargin, lecithin, methionine, ornithine, Tsitrarginin;
• synthetic hepatoprotectors - Antral, ziksorin, Thiotriazoline ;
• homeopathic hepatoprotectors - Galstena, Hepar compositum Hepel, Hall-Grand .

Available as a set of synonyms legalon - drugs, the active ingredient of which is a fruit extract of milk thistle. It CARS Geparsil, Leprotek, Naturkarsevt, Natursil, Silegon, Silibinin, Silibor, Silimar, Silymarin, Siromin.

Combined hepatoprotectors, which include milk thistle and other vegetable components: Gepabene, Gepatofalk plantations, Gepatovet and etc.

Reviews legalon

Reviews of this preparation mostly positive: long-term use consistently improves the condition of patients.   Reviews on Legalon 140   It indicates that a large dose of the drug in most cases justified. Reviews of doctors all positive - the drug is effective as a part of complex treatment and as monotherapy.

Negative reviews   about this drug is very small. But if you go to the forum, you can find them. Mostly negative feedback due to the fact that when taking legalon no immediate therapeutic effect. Indeed, this herbal product, so it acts slowly.

Price legalon

Legalon price depends on the number of capsules in the package. Prices in Moscow are different:

• Price Legalon 70, 20 units-from 183 to 208 rubles;
• Price Legalon 70, 30 pcs. - From 245 to 272 rubles;
• Price Legalon 70, 60 pcs. - From 385 to 477 rubles;
• Legalon price 140, 20 pieces - from 310 to 314 rubles;
• Price Legalon 140, 30 pcs. - From 320 to 399 rubles;
• Price Legalon 140, 60 pcs. - From 550 to 698 rubles.

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