Safotsid

Description overdue on 03/09/2013

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Combined product: azithromycin, fluconazole, seknidazol. The drug has antibacterial, antifungal and antiprotozoal effects. The first component - fluconazole   has antifungal effect . Selectively inhibits sterol synthesis process in fungal cell. It is active against fungi Candida, Trichophyton, cryptococci, microspores.

The second component - azithromycin   It is azalide antibiotic . Component bactericidal effect when creating high concentrations in inflammatory foci. It affects streptococci, Gardnerella, Neisseria, Chlamydia, Mycoplasma, Treponema, ureaplasmas. Azithromycin has no effect on gram-positive microflora, which is resistant to erythromycin.

The third component - seknidazol   It has antimicrobial, antiprotozoal effects. It is a derivative of nitroimidazole synthetic origin. It does not affect the aerobic bacteria. Component characteristic teturamopodobnoe action, it causes sensitization to alcohol and increases the sensitivity of tumors to irradiation. The principle is based on the impact of the destruction of the spiral structure, the suppression of the process for synthesizing nucleic acid strand breaks, cell death. Safotsid available in tablet dosage form.

Indications:

Drug Usage Safotsid recommends prescribers when co-infection in the urogenital system, sexually transmitted diseases: chlamydia, gonorrhea, urethritis , Cystitis (specific and nonspecific), a fungal infection, trichomoniasis, bacterial vaginosis, cervicitis, vulvovaginitis .

Contraindications:

Safotsid does not apply in case of intolerance of fluconazole, azithromycin, seknidazol, macrolides, nitroimidazoles, with organic pathology of the central nervous system, pregnancy, breastfeeding, concurrent therapy astemizole, terfenadine and other drugs, on the background of which there is lengthening of the interval QT. When treating drugs that are metabolized by P450   (e.g., rifabutin, cisapride) Safotsid prescribed with caution.

Side effect:

Senses:   rare in violation of taste perception. Cardiovascular system:   rarely develop cardiac arrhythmia . Hepatic system, the digestive tract:   violation of appetite, flatulence, problems with the digestive system, diarrhea, nausea, vomiting, epigastric pain. Hematopoietic system:   leukopenia. Allergic response: anaphylactic reactions Itching, skin rash. Occasionally during treatment developed stomatitis , Headaches and dizziness.

Mode of application:

Safotsid take once, inside. The blister contained 4 tablets to be taken 1 hour before eating or 2 hours after a meal (taking into account the effect of azithromycin change depending on the time of reception).

Special instructions:

Responses to the drug Safotsid show high efficacy in the treatment of infections, sexually transmitted diseases. The medicament is discharged in the form of a set of tablets. The price of the drug Safotsid varies depending on the pharmacy and region. The drug is released upon presentation of a medical prescription form. Blisters should be kept at a temperature not exceeding 30 degrees Celsius, in a dry place.

Drug Interactions:

Due outside the medication components.
Fluconazole.   Simultaneous treatment with warfarin can lead to an increase in prothrombin index 12%. When treating anti kumarinovyh   mandatory control over changes in prothrombin time. In healthy people, a component capable of increasing the half-life sulfonylureas (tolbutamide, glibenclamide, chlorpropamide, glipizide) oral hypoglycemic agents   (increased risk hypoglycemia ). Fluconazole reduces the rate of average clearance rate of theophylline. It is unacceptable simultaneous treatment astemizole , Terfenadine and other drugs that prolong the QT.

Azithromycin . Ethanol, and aluminum-magnesium- antacids , Food reduce and slow down the speed and completeness   Absorption . Simultaneous treatment with azithromycin and warfarin leads to increased anticoagulant effect, which requires close monitoring of prothrombin time. In the treatment of digoxin and azithromycin observed increase in the first drug in the blood. Dihydroergotamine, ergotamine   enhance the toxic effects (dysesthesia, vasospasm).

Azithromycin is able to raise the level, slows down and increases the toxicity of methylprednisolone , Indirect anticoagulants, felodipine, cycloserine, and also drugs that are subject to microsomal oxidation (cyclosporine, terfenadine, carbamazepine, valproic acid, geksobarbital, theophylline, phenytoin, bromocriptine , Disopyramide, alkaloids sporyni.yu xanthine derivatives) due to inhibition of the process microsomal oxidation azithromycin cells hepatocytes. Efficiency component amplify chloramphenicol, tetracycline, weaken -linkozamidy.

Seknidazol.   The component is able to enhance the hypoglycemic effects of antidiabetic oral medication and insulin . Disulfiramopodobnyh reaction   develop while taking alcoholic beverages (headaches, vomiting, epigastric cramps, flushing of blood flow to the face, nausea).