Levamisole

Description overdue on 14.02.2012

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Anthelmintic agent.   The mechanism of action is aimed at the oppression fumaratreduktazy, blocking of succinate dehydrogenase, disrupting biological energy processes in helminths. Levamisole depolarizing muscle membrane parasites. The drug improves function monocytes Stimulates the proliferation of activated T and B lymphocytes, enhances T cell response increases the function of neutrophils, macrophages, increases the synthesis of antibodies to various antigens. Levamisole is available in tablet form.

Indications and contraindications:

Levamisole is prescribed for necatoriasis , Hookworm, ascariasis, trihostrongileze, toxoplasmosis, enterobioze, trihotsefaleze. The drug is not used in pediatric practice before reaching 14 years of age, pregnancy, agranulocytosis, breastfeeding. In the acute phase of leukemia, cerebrovascular disease, inhibition of bone marrow hematopoiesis, hepatic failure and renal systems Levamisole used with caution.

Side effect:

Digestive system:   epigastric pain, diarrhea, nausea, pancreatitis , Increasing alkaline phosphatase Rarely marked ulceration of the mouth. Nervous system : Olfactory hallucinations , Peripheral polyneuropathy, paresthesia , Headaches, entsefalopodobny syndrome, generalized convulsions, lethargy, speech disorder. Rarely observed tremor, fatigue, ataxia, confusion, sleep disturbances. Bodies of blood: agranulocytosis , Leukopenia. Urinary system:   hypercreatininemia defeat the renal system. Perhaps the development of allergic reactions, exfoliative dermatitis, skin rashes. In rare cases, there is lymphadenopathy, vasculitis , Iridocyclitis, taste perversion, myasthenia gravis, periorbital edema , Uterine bleeding.

Mode of application:

Levamisole is taken with food, inside. Helminthiasis : Re bedtime 150 mg dosage for children is calculated individually according to the scheme 2, 5 mg / kg. Toxoplasmosis : Three days of 150 mg, a break week, and then a course of therapy.

Special instructions:

Before anthelmintic treatment is necessary to analyze the state of the peripheral blood, to pay special attention to the number of white blood cells. Levamisole had previously been used for immune stimulation in the immune diseases, immunodeficiency, autoimmune diseases: thrush . Reiter's disease Crohn's disease, rheumatoid arthritis, systemic lupus erythematosus , Tumors of the large intestine of the bronchial system, breast, Hodgkin disease, leukemia, chronic pyelonephritis , Chronic glomerulonephritis, ulcerative lesions of the digestive system.

Drug Interactions:

Levamisole is incompatible with ethanol (developing disulfiramopodobnye reaction), lipophilic compounds, drugs that cause leukopenia . Levamisole enhances the action anticoagulants   and phenytoin. Simultaneous treatment with myelotoxic drugs enhances haematological influence.