Contrycal

Description overdue on 06/23/2014

• Latin name: Contrykal
• ATC code: B02AB01
• Active substance: Aprotinin (Aprotininum)
• Manufacturer: IDT Biologica, Germany

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications kontrikala
• Contraindications
• Side effects
• Instructions for use kontrikala (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

On 1 bottle accounts for 10 thousand. Units antitrypsin aprotinin , Adjuvant is mannitol .

Product form

The lyophilized substance , In bottles 5 pcs. contour packaging and complete with saline dilution powder.

This form such as tablets, are not released.

Pharmacological action

The drug is in its structure polypeptide and prepared from the lung tissue of cattle. Inhibits kallikrein-kinin system   both in general and its individual components. Blocks proteases are actively involved in fibrinolysis . plasmin . trypsin   and other enzymes.

Contrycal oppresses fibrinolysis   and is used for coagulopathies   as gemostatiki .

1 Antitrypsin unit corresponds to 1, 33 inactivating kallikrein units (KIU).

Pharmacodynamics and pharmacokinetics

Aprotinin   in the gastro-intestinal tract is inactivated. The half-life of up to 10 hours. Excreted by the kidneys.

Indications kontrikala

• pancreatitis   in the acute phase;
• pancreatonecrosis ;
• Pancreas surgery for prevention autolysis ;
• bleeding Caused by the activation of fibrinolysis (post-operative, post-natal, post-traumatic, polimenoreya );
• all types shock   (traumatic, hemorrhagic, toxic, burn);
• prevention of postoperative mumps;
• angioedema ;
• massive soft tissue damage due to injury;
• prevention of postoperative bleeding and pulmonary embolism .

There are also indications for use in the treatment of kontrikala coagulopathies   and bleeding.

Contraindications

• pregnancy   I and III trimester;
• DIC ;
• lactation;
• intolerance to the protein in cattle;
• individual sensitivity to the drug.

Side effects

Heart and blood vessels : tachycardia   and hypotension .

CNS : hallucinations , Psychotic disorders, impaired consciousness.

Digestive System : In case of a rapid administration may be nausea and vomiting.

Allergy : conjunctivitis . hives . bronchospasm . anaphylactic shock .

In the case of continuous infusion - phlebitis   and thrombophlebitis .

Instructions for use kontrikala (method and dosage)

The dose depends on the severity and the clinical picture. Inject intravenously. The starting dose in most cases is 500 thousand. KIU to maintain - 50 thousand. KIU per hour.

Overdose

The symptoms were not observed. Presumably, the side effects may be intensified.

Cooperation

Concomitant use with Heparin   increases the clotting time.

Combination with reomakrodeksom   the ability to enhance sensitization to both drugs.

Contrycal inhibits streptokinase . alteplase   and urokinase .

Aprotinin   weakly inhibit pseudocholinesterase, which can lead to a more pronounced miorelaxation   and apnea .

Terms of sale

Prescription.

Storage conditions

The temperature which does not exceed 25 ° C.

Shelf life

3 years.

Cautions

Instructions on Contrycal indicates the need for a skin test prior to administration of the drug in order to avoid allergies. If the patient has previously had an allergic reaction to medication administered glucocorticosteroids   and antihistamines .

With DIC - syndrome   and hyperfibrinolysis   introduced after the elimination of all violations, and at the same time Heparin .

If the patient for 2-3 days prior to initiation of therapy was administered muscle relaxants , Contrycal used with caution.

Analogs kontrikala

Match code ATC 4th level:

• Gordoks

Main counterparts kontrikala: Kontriven . Aproteks . Trasylol

The most common substitute - it Gordoks .

Synonyms kontrikala

Aprotinin . Gordoks . Aproteks.

Babies

Applied indicated. The dose is determined according to body weight.

During pregnancy and lactation

Strict contraindication is the use of I and III trimester of pregnancy. No data on the efficacy and safety of lactation and in the II trimester of pregnancy.

Reviews Kontrikale

Major reviews are available on the forums - from patients pancreatitis . Contrycal widely used in the exacerbation chronic pancreatitis Because it is quite effective in this pathology. Improvement occurs just after the first drip. But also note that the drug is strong allergen And after treatment they can inhibit the enzymatic activity pancreas .

Price kontrikala where to buy Contrycal

Buy Contrycal in Moscow can be from 605 rubles. to 771 rubles. In St. Petersburg, the average cost of the drug is 645 rubles.

Price kontrikala ampoules in Ukraine an average of about 497 UAH.

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