Mirolyut

Description overdue on 10/07/2014

• Latin name: Mirolut
• ATC code: G02AD06
• Active substance: Misoprostol (Misoprostol)
• Manufacturer: JSC "Obninsk chemical and pharmaceutical company", Russia

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Mirolyut (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Reviews
• Price, where to buy

Composition

The preparation contains 20 mg of active substance - Misoprostol .

Other ingredients that are part of the drug - sodium carboxymethyl starch, prosolv (colloidal silicon dioxide and MCC), magnesium stearate.

Product form

Mirolyut produce a spigot white tablets (sometimes have a yellow or gray shade) risks and beveled. The blisters or plastic jars can be 4, 10, 20 or 30 tablets.

Pharmacological action

Mirolyut prostaglandinopodobnym a means of stimulating labor.

Pharmacodynamics and pharmacokinetics

Misoprostol is a synthetic derivative of Prostaglandin E1 . It causes the expansion of the uterus, and contraction of muscle fibers of the myometrium. Disclosure of the cervix and, respectively, removing the contents of its cavity, facilitated by the ability to stimulate uterine misoprostol.

Mirolyut able to provide a lesser degree stimulates the muscles of the digestive tract. In large doses, Misoprostol   It inhibits the secretion of gastric juice.

No clinically significant effect on the levels of growth hormone, gonadotropin, cortisol, thyroid stimulating hormone, thyroxine, creatinine, on prolactin, lung function, platelet aggregation and the cardiovascular system.

It absorbs quickly. Bioavailability of the substance is reduced, while taking with food (absorption decreases due to fatty foods, absorption length is not changed).

It is metabolized in the liver and the gastrointestinal tract to the walls misoprostol acid . The maximum concentration of the metabolite occurs within 15-30 minutes. The period starts to operate through many drug - 30 minutes and a duration of effect - 3-6 hours. Not accumulates. The half-life - 30 minutes.

Excreted through the kidneys and bowels.

Indications

The drug is prescribed for a medical abortion in conjunction with Mifepristone . Designed for the termination of pregnancy - up to 42 days of amenorrhea.

Contraindications

Medication is prohibited in the following cases:

• kidney disease   and liver ;
• anemia ;
• sensitivity to the components of the drug;
• endocrinopathies , Endocrine disorders (including adrenal dysfunction   and diabetes );
• lactation;
• cardiovascular diseases;
• use IUD   (IUD should be removed before starting);
• hormonal tumor;
• diseases in which prostaglandins contraindicated reception: bronchial asthma . glaucoma . arterial hypertension ;
• diseases that are associated with prostaglandin disease;
• the likelihood of an ectopic pregnancy.

Side effects

During drug administration may arise Mirolyut side effects listed below:

• headache ;
• hyperthermia ;
• vomiting;
• cramping;
• flatulence ;
• skin rash;
• dizziness ;
• nausea;
• diarrhea .

When you receive misoprostol at the recommended doses instruction adverse reactions from the kidneys, liver and the cardiovascular system are not shown.

Instructions on Mirolyut (method and dosage)

Mirolyut tablets taken by mouth. In combination with Mifepristone   should be taken only under a doctor's prescription and under constant supervision in medical institutions obstetrician, if necessary, to specialists to provide emergency surgical and gynecological transfusion support. It requires all the activities that go along with abortion.

Therapy begins with receiving 3 tablets (600 mg) of mifepristone, after 3-4 days prescribed 2 tablets (400 mg) means Mirolyut.

Overdose

In humans the toxicity of the active substance has not been identified. In excess doses can manifest clinical signs: epigastric pain . drowsiness . hypotension . bradycardia . tremor . tachycardia . convulsive reaction . fever , Slowing the heart rate.

Cooperation

Metabolism Misoprostol   stimulated at reception for a long time Isoniazid . Antidepressants . Rifampicin , Anticonvulsants Indomethacin . acetylsalicylic acid , Drugs of the group phenobarbital . Tsimedina . Nicotine , Thereby reducing the level of its content in the blood.

You should not take Aspirin   and other non-steroidal anti-inflammatory drugs for one week after taking the drug Mirolyut.

Antacids interfere with the absorption of the active substance medications Mirolyut. The combination of magnesium-containing antacids and misoprostol can lead to increased diarrhea.

Terms of sale

Buy Mirolyut a pharmacy only if you have a prescription.

Storage conditions

The optimum temperature for storage - 25 ° C, kept in the dark is not a humid place.

Shelf life

Store no more than 3 years.

Cautions

When using the drug for the termination of pregnancy up to 42 days is necessary to combine drugs Mirolyut and mifepristone. Thus, this therapy should be carried out for any other purpose, under the supervision of a specialist doctor in a specialized facility where it is possible to provide emergency surgical and gynecological transfusion support.

The drug requires all the activities that go along with abortion, including the prevention of Rh-factor.

It is necessary to inform the patient about the effects and side effects of the drug before his appointment. For 4-6 hours before taking the medicine the patient should be observed in the hospital. In the event of massive bleeding or other complications during or after treatment, an urgent need to provide medical assistance.

You may experience some vaginal bleeding after mifepristone (some women can last for a long time). At a very early term abortion is possible after taking the drug, but in this case in order to optimize the results you need to take pills Mirolyut. After receiving its abortion occurs within 6 hours in 80% of patients in a week - 10% of patients.

After 8-15 days after taking the medicine need to go to the hospital re-examination. If necessary, carry out or ultrasound to determine the level of human chorionic gonadotropin in the blood. If you suspect to preserve pregnancy or incomplete abortion, should conduct a full medical examination.

Upon detection of incomplete abortion or continue the pregnancy, evaluated 2 weeks after the use of mifepristone, it is necessary to hold vacuum aspiration with histological examination of aspirate as necessary to assess the influence of the formation of congenital malformations in the fetus.

Analogs

By means of having similar pharmacological action include Mizotab   and Misoprostil .

Miropriston and Mirolyut

Preparations Mirolyut Miropriston and can not be regarded as analogues, as they are taken in combination for medical abortion in the early stages. These drugs are used in the treatment and are not interchangeable.

Reviews and Mirolyute Miropristone suggest that strict compliance with the instructions and advice of a doctor, the effectiveness of drugs is quite high. However, when used after 42 days of pregnancy, there is a possibility of complications such as incomplete abortion.

Reviews Mirolyute

Opinion about the preparation of patients is quite controversial: many say the occurrence of side effects, severe bleeding with abdominal pain. Reviews Mirolyute forums indicate that when properly taking the drug, abortion is fairly painless and with a good result. The lower the gestational age, the greater the chance of a minimum of side effects.

Price Mirolyuta where to buy

Tablets Mirolyut can be purchased on the territory of Russia and Ukraine. In Russia, the price Mirolyuta the pharmacy is about 900 rubles (per pack of 10 tablets), the price in Ukraine is about 124 USD. (4 tablets).

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