Futsis

Description overdue on 09/25/2014

• Latin name: Fusys
• ATC code: J02AC01
• Active substance: Fluconazole (Fuconazole)
• Manufacturer: Kusum Helthker.ltd., India

Photos of the drug

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Futsis (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

Tablets Futsis   contain the active substance - Fluconazole   in varying dosage, and also auxiliary components.

AT tablets Futsis DT   It contains 50 mg Fluconazole and auxiliaries.

Part solution for infusion administration   100 ml encompasses: Fluconazole - 200 mg and additional components.

As auxiliaries   used: microcrystalline cellulose, lactose, povidone K30, magnesium stearate, talc, sodium starch glycolate, croscarmellose sodium and so on.

Gel Futsis   It includes in its membership Fluconazole - 5 mg Excipients : Carbomer, benzyl alcohol, octyldodecanol, polysorbate 80, propylene glycol, sodium hydroxide, flavor Delite and purified water.

Product form

The drug is available in the form of tablets with a dosage of 50, 100, 150 and 200 mg of active substance to 4 pcs. in a blister, packed in a cardboard box. Futsis Tablets 150 mg - 1 piece. in a blister pack, placed in a cardboard box. Tablets dispersed with 50 mg acting component on 4 pcs. in a blister, packed in a cardboard box.

A solution for intravenous administration in bottles of 100 ml, one bottle in a cardboard box.

A preparation in form of gel is invited in a tuba to 30 g, packaged in cardboard wad.

Pharmacological action

Each form of the drug has antifungal effect   broad spectrum of activity.

Pharmacodynamics and pharmacokinetics

Fluconazole, the active ingredient of the drug is a synthetic derivative of the group thiazole compounds. The effect of this material eliminates the enzymatic activity of specific compounds in the cells of fungi. As a result of sterol biosynthesis of damaged joints in fungal cells, inhibits the conversion of   lanosterol at ergosterol . Changes in the cell membrane causes the cessation of reproduction of fungi due to violations of replication. The effectiveness Futsisa directed to strains such as: Coccidioides immitis, Cryptococcus neoformans, Trichophytum spp. and Microsporum spp., Hystoplasma capsulatum, Blastomyces dermatitidis, and so on.

For the Fluconazole is characteristic low toxicity, therefore the drug is not exerts the negative impact of on an organism and significant impact on the cytochromes human and abundance of androgenic hormones in the composition of of blood plasma.

Tablets intended for indoor reception, well absorbed in the gastrointestinal tract. Fluconazole has high bioavailability, the use of food has no effect on the absorption process. Maximum concentration in blood plasma has detected after 30-90 minutes from the time of reception.

It exhibits good penetration into the substance of biological fluids and tissues. Furthermore, Fluconazole penetrates c / o blood brain barrier, cerebrospinal fluid concentrating to 80% of plasma concentrations. Excretion Fluconazole is carried in the urine - a part intact, the rest - metabolites . The half-life is 30 hours.

Farmokinentika intravenous administration Fluconazole is virtually identical to the received orally.

Antifungal agent   as gel   It possesses such same activity and the characteristics of, as the and other forms of Futsisa. Especially effective it affects dermatophytes   and   yeast .

During outdoor use only a small amount substance adjudged into the plasma blood, therefore its systemic action you can exclude. It is also found that the gel does not have a negative impact on the skin.

Indications

The main indications for the use of a Futsisa the need for treatment of infectious diseases of different localization Caused by microorganisms are sensitive to fluconazole.

Pills   prescribed for:

• Candida infections   different localization - candidemia, candiduria, disseminated candidiasis,   other forms generalized candidiasis Caused by the fungus Candida;
• infections of the mucous membranes Which cause fungi Candida;
• bronchopulmonary   non-invasive candidiasis infections ;
• chronic candidiasis   the oral cavity, associated with wearing of removable dentures;
• the treatment of acute and chronic recurrent vaginal candidiasis;
• therapy sporotrichosis, histoplasmosis   and area points of of endemic of mycoses ;
• treatment d ermatomikozov, mycosis   in the groin and on the feet, onychomycosis   and pityriasis depriving .

Also, pills may be appointed for the relapse prevention   in patients with:

• chronic vaginal candidiasis;
• candidal balanitis;
• cryptococcal infection   various localization and so on;
• g ribkovymi infections   of various localization, if patients suffer immunodeficient or are receiving cytostatic and radiation therapy.

The solution for infusion administration   prescribed for the treatment of:

• systemic fungal infections, for example:   candidemia, candiduria, Candida infections of the eyes, endocardial ;
• cryptococcal meningitis;
• cryptococcal infections   the skin surface and respiratory organs.

Gel   used for the treatment:

• dermatomycoses That cause yeast;
• dermatophytes   - Athlete's foot, jock itch, trihofitii, kandidnyh infections, multi-colored lichen.

Contraindications

Not recommended for use when Futsis:

• individual Sensitivity   its components and other azole compounds, whose structure is close to fluconazole;
• lactation, pregnancy;
• the age of 7 years.

This indicates that Futsis DT can be used for children from 3 years.

Side effects

Application Futsisa can cause a number of side effects affecting the work:

• Nervous System   - Headache, dizziness, tremors, convulsions;
• cardiovascular system   - Arrhythmia, tachycardia ;
• the liver and gastrointestinal tract   - Nausea, vomiting, pain, digestive disorders, diarrhea and so on.

Also, undesirable manifestations on the skin   and allergic reactions : alopecia, toxic epidermal necrosis . itching, skin rash, hives, swelling, Stevens-Johnson syndrome .

In addition, the use of Fluconazole It may affect the laboratory results : Leukopenia, neutropenia, agranulocytosis, thrombocytopenia, hypokalemia, the level of cholesterol and triglycerides in the composition of blood.

The manifestation of the side effects require discontinuation of Futsisa.

Instructions on the Futsis (Method and dosage)

The preparation tablets   the content of 50-200 mg Fluconazole is used in the treatment of adults and children of 7 years. Accepts them orally in the any time. The daily dosage of the drug is established at one go.

Tablets Futsis DT   User is recommended to dissolve in water. Also allowed Futsis DT for children from 3 years. Typically, the drug is used at 50mg 5ml water.

AT R astvore infusion   It contains 200 mg of fluconazole with 100 ml of isotonic sodium chloride solution. When the infusion solution is administered to patients who should limit the introduction of fluid and sodium need to consider the content of sodium and chlorine in the solution is 15 mM. The drug is not recommended to mix with any solution for infusion, despite the absence of a pronounced pharmacological incompatibility.

Gel   Futsis instructions for use recommends using every day. This means gently rubbed into the affected areas of skin around them.

It should apply a very small amount of gel and triturated it across the surface to prevent maceration.

The dosage and duration of treatment of each form of the drug is determined by the attending physician. For example, patients suffering from genital candidiasis appointed single 150 mg fluconazole tablets. To prevent a recurrence of chronic vaginal candidiasis - from yeast appointed 150 mg of the drug per month. This takes into account the nature of the disease and the individual characteristics of the patient. The dosage of the drug is independent of the use and is usually not changed in case of transition from the parenteral to oral administration.

Overdose

In cases of overdose of tablets or solution Futsis may develop negative symptoms such as: headache . dizziness   or hallucinations . Also, do not exclude the occurrence of paranoid behavior of patients.

In such cases, carry out gastric lavage and other symptomatic therapy. Allowed the use of forced diuresis and hemodialysis.

No cases of overdose caused by the use of the drug in gel form, are not reported.

Cooperation

The simultaneous use of tablets or solution Futsis with anticoagulants can significantly enhance their effect. Therefore, you must perform regular monitoring of indicators of the prothrombin time.

This may increase the plasma drug concentration midazolam, benzodiazepine, cyclosporine, rifabutin   and phenytoin   in the blood. In the combined treatment flucanozole and any of the funds required strict control of dosing and monitoring specialist. Failure to comply with of these rules can cause the development of psychomotor reactions, to strengthen side effects associated with the work of the cardiovascular system and so on.
If you regularly use hydrochlorothiazide   with Futsisom, we can expect a significant increase in plasma concentrations of fluconazole, but it does not require dose adjustment.

Admission does not reduce the effect of Fluconazole combined oral contraceptives .

During the treatment of patients with Futsisom diabetes   We must take into account the likelihood of hypoglycemia. Simultaneous use with   rifampicin   It requires increasing doses of Fluconazole. The combination of fluconazole   tacrolimus   often causes mutual enhancement of nephrotoxicity. When the drug is taken with theophylline Then there is likely to overdose theophylline Because it will reduce the clearance Fluconazole theophylline   from the blood plasma.

With regard to the gel Futsis, then of data about his drug interactions with other medications not reported. It is recommended to abstain from simultaneous application of any external means.

Terms of sale

The drug prescription.

Storage conditions

For storage Futsisa requires a cool, dry place, protected from light and children.

Shelf life

3 years.

Analogs

Match code ATC 4th level:

• Flucostat
• Diflyuzol
• Rumikoz
• Vero Fluconazole
• Kandizol
• Kanditral
• Itraconazole
• Mikosist
• Diflazon
• Itrazol
• Diflucan
• Orungal
• Mikomaks
• Fluconazole
• Irunine

For drugs with similar action are: Fluconazole, clotrimazole, Fukortsin   and Livarol.

Alcohol

In the treatment of any form of the drug alcohol is highly undesirable Since it can not only reduce a therapeutic effect, but lead to side effects.

Reviews Futsise

This drug is widely applied in the treatment of thrush . However, many users report that Futsis helps get rid of the disease for many years. Of course, should not be forget about the additional therapy, helps to restore normal microflora of vaginal environment.

However, by using a tablet Futsis thrush Some patients reported   the development of side effects . This is usually manifested swelling, itching of the mucous membranes of the nose and eyes, headache, and fever.

Another problem is the independent use of the drug. Not attending physician, patients buy these pills, and then interest on the forums, how to take thrush that the treatment was effective.

Pro   gel   Futsis reviews patients are less common, but almost all of them positive . This is particularly useful in the treatment agent dermatomycoses . However, despite the high efficiency of of the given preparation, prior to the beginning of treatment need to address to the doctor to select the optimal dosage and schemes of treatment.

Price Futsisa where to buy

Price Futsis 150mg in Ukraine is about 42 UAH. Thus the price tablets in such cities, as the Donetsk or Harkov varies within the limits 40-52 UAH., Gel - 60-65 UAH.

In the online pharmacies in Moscow Futsis 150 mg can be ordered at the price of 349 rubles.

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What are the medicinal properties of red wine have?

June 14, 2011

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It has long been said that Red wine   helpful. Why is that? As a result of long research, scientists have found that the composition of red wine includes a number of substances that hinder the development of atherosclerosis , Dilates blood vessels and protects against heart attack . The grape skin contains the active substance melatonin Retarding the aging process of cells and plays the role of an antioxidant, which does not allow patients to damage healthy cells. This natural hormone found in the same cherries, bananas, onions, rice.

In addition, the favorite drink of many Europeans, has other beneficial properties: in grape seeds contain an enzyme, impeding the development of cancer cells and prevent gum disease. It bears will be a glass of wine for people suffering from insomnia. Because of these properties, the Spanish scientists have named the wine elixir of youth. This applies only to natural dry red wines.

However, doctors warn that excessive   the use of wine leads to heart attack and cirrhosis As well as other diseases, such as alcoholism . Women overdose can lead over time to infertility . Therefore, it is important not to abuse it useful, but harmful in large quantities, drink. For adult male daily dose is about 200 ml for women - 100-150 ml.

Ferezol

Description overdue on 09/10/2014

• Latin name: Pheresolum
• ATC code: D11AF
• Active substance: Phenol (Phenol), tricresol (Tricresolum)
• Manufacturer: Retinoids (Russia)

Photos of the drug

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions for use Ferezola (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy

Composition

The preparation includes phenol   and tricresol .

Product form

Ferezol available as a solution for outdoor applications.

Pharmacological action

Antiseptic   and cautery   means.

Pharmacodynamics and pharmacokinetics

The drug is combined with means cauterizing   and bactericidal   action. The specificity of action is irreversible coagulation proteins That it is vital structures of the microbe that provokes the loss of their functions and death. The drug affects many bacteria, fungi, viruses and protozoa. Cauterizing properties are due to the destruction of macromolecules cell fibers of the skin and mucous membranes. When interacting with body tissues provokes chemical burns.

Indications

Common, plantar and filamentous Warts . genital warts skin .   dry corn . keratomas . papilloma .

Contraindications

Ferezol can not be used in case of hypersensitivity to the drug. Furthermore, among the contraindications are marked nevi , Rashes around the lips and mucous membranes, moles.

The solution should not be applied to the skin for more than 20 square meters. cm.

Children under 7 are not used.

For pregnant and lactating women are allowed to use the drug only if the benefit of treatment is higher the likely risk to the child. However, if there is a formation on the mammary glands during Lactation   Ferezol use is not recommended. In addition, at this time you can not use it to remove the structures on the hands.

Side effects

Side effects may include the following:

• skin if treated area of ​​skin around the eyes, swelling of the retina is possible, which usually resolves on its own;
• the immune system: allergy ;
• general reactions: burning sensation at the site where the medication is applied.

Instructions for use Ferezola (method and dosage)

Use solution can only be on the skin. Instructions for use According to that it should be applied precisely to the area to be treated, a small wooden stick. It is important to ensure that the vehicle has not got a healthy skin and mucous membranes. In papilloma   to 2 mm and filiform warts   the drug is applied once. Larger size papilloma   and   Warts   from 2 to 3 mm lubricated 3-4 times, between which it is necessary to make a break for the solution has dried.

Before removed by Ferezola Warts   on chapped hands with a dense surface, keratomas . plantar warts   and dry corn , Must be removed from the surface of the horny layers. For this purpose the keratolytic ointment . She applied for a few hours, covering the treated area of ​​skin compress paper or plastic wrap and zabintovyvaya gauze bandage or plaster gluing. Then it is removed and the skin steamed in hot soapy water with the addition of soda for 10-15 minutes and remove the nail scissors or forceps horny layers. Ferezol applied to the skin several times with breaks for 3-4 minutes for drying:

• Warts on the hands and the soles are handled 7-10 times;
• keratomas   and dry corn   handled 3-4 times.

In order to avoid burning of healthy skin, can be lubricated with zinc paste, which after use of the drug is removed with dry gauze.

Instructions on Ferezol reports that genital warts   better removed in the clinic in the office dermatologist or urologist. The drug is applied 1-2 times at intervals of 3-4 minutes.

Use this product can again 6-8 days after subsides crust. There should be no more than 4-5 procedures.

If the vial precipitated crystals, it should be heated in a water bath at a temperature of about 30 degrees, just shaking the contents. After the crystals were dissolved, the drug may be used.

Overdose

If Ferezol hit a large area of ​​skin may be a chemical burn, and general intoxication.

Treatment is symptomatic.

Cooperation

The solution can not be mixed with ointments, as in this case, it loses its effectiveness.

Terms of sale

In Russia, the tool is released from pharmacies without a prescription, in Ukraine - a prescription.

Storage conditions

The medicine should be kept in their original packaging. The temperature should be 8-15 ° C.

Keep need the reach of small children.

Shelf life

Five years from the date printed on the package.

Analogs Ferezola

Match code ATC 4th level:

• Verrukatsid

Analogs Ferezola pharmacies can be found the following:

• Solkoderm ;
• Urgokor helotic .

Each of the products has its own nuances of the application. Before replacing for analogs Ferezola consult with your doctor.

Reviews Ferezole

The drug is very common. Those who have used it on the wart, reviews Ferezol leave mostly positive. However, it is important to use it according to instructions.

Reviews Ferezole also reported and that means it's pretty painful. Often, it happens from burns and scars on the skin. That is why many patients still prefer other methods, such as freezing or laser cauterization. However, they should not appoint myself independently. Use one or the other means is necessary only after consulting your doctor.

Price Ferezola where to buy

Buy Ferezol in Moscow and other Russian cities can be of a different value depending on the volume of the vial. Typically, it is offered in drugstores in flakonchike 10 g, contained in a cardboard package. Price Ferezola in rubles, the average is 252 rubles. However, in large cities it can cost more. For example, to buy in St. Petersburg this tool can be as low as 300 rubles.

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Dermazol

Description overdue on 08/13/2014

• Latin name: Dermazol
• ATC code: D01AC08
• Active substance: Ketoconazole (Ketoconazole)
• Manufacturer: Kusum Healthcare (India)

Photos of the drug

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Dermazol (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Reviews
• Price, where to buy

Composition

All forms release drug contain, as the main active ingredient ketoconazole .

Cream Dermazol   for external application, moreover, has the following additional components: polysorbate 80, disodium EDTA, white soft paraffin, 1000 ketomakrogol, anhydrous sodium sulfite, propylene glycol, purified water, alcohol ketosterilovy , Paraffin, light liquid.

Pills   in addition to the main active ingredient contain additional ingredients such as microcrystalline cellulose, magnesium stearate, butylhydroxytoluene, croscarmellose sodium, colloidal silicon dioxide.

Part shampoo   includes the following excipients: sodium lauryl sulfate, sodium chloride, flavor, sodium hydroxide, butylated gidroksitoluen, purified water, kokodietanolamid, hydrochloric acid, dye, disodium sulfosuccinate monolauril ether, propylene glycol.

Product form

The drug is available in tablet form for oral administration, a cream to lubricate the affected places of skin, as well as in the form of a shampoo for washing the hair and vaginal suppositories.

Pharmacological action

Dermazol - an antifungal drug broad spectrum. It is used for local and systemic treatment fungal infections .

Pharmacodynamics and pharmacokinetics

The active ingredient of the drug can have both fungicidal And fungistatic   action aimed at dermatophytes . dimorphic . eumitsety   and yeasts .

The fungicidal action   It is to change the structure and reducing the strength of the fungal cell membrane, leading to the death of fungi.

Fungistasis   the active substance is preventing formation of new colonies of fungi. In addition, the drug is marked antimicrobial activity against most staphylococci   and streptococci .

Penetrated into fungal cells Dermazol prevents the synthesis of compounds, which are the basis of the cell membrane of the fungus. Due to this, there are various permanent changes in the structure of the cell membrane.

It is effective against many fungal infections. With prolonged use of marked decrease in the biosynthesis Testosterone   and other androgenic hormones .

Tablets Dermazol   well absorbed in the intestine. Bioavailability in this case - 75%. The high concentration in biological fluids and tissues. Active substance accumulates mainly in the liver, lung, kidney and cardiac muscle. It has good permeability through blood-brain barrier Also known for its high levels of plasma protein binding. Studies have shown a pronounced dose-dependent effect.

The maximum concentration of drug in blood plasma occurs within 1-2 hours after application. Withdrawal is carried out in two stages. Cleaves to form inactive metabolites. Mainly excreted in the bile, about 15% - with urine. It may be isolated in the form of active metabolites and unaltered.

When used in the form of cream   and shampoo   drug does not have general systemic effects and does not reach the bloodstream.

Indications

For each specific fungal disease Only a doctor can prescribe an effective scheme of application of this drug. If the drug release form or duration of treatment will be selected properly, it may lead to relapse. It is necessary to determine the type fungus-pathogen As in some cases, a complex therapy, and the use of only one Dermazola will not be enough.

Before using the drug orally it is necessary to check the condition of the liver. At the same time, if applied ointment Dermazol, is not necessary.

The preparation for external use is indicated for the treatment and prevention fungal infections   skin, jock itch . tinea   smooth skin athlete hands and feet, as well as candidiasis   skin.

For topical medication used for the treatment of relapsing vaginal candidiasis And in some cases for the prevention fungal infections of the vagina .

Tablets Dermazol prescribed most often in inaccessible and intolerant of other therapies. They are used in the case of blastomycosis . histoplasmosis . paracoccidioidomycosis . coccidioidomycosis   and chromomycosis .

Contraindications

Dermazol release in any form is contraindicated if you are hypersensitive to use the components of the drug.

Tablets should not be used in the presence of liver disease and children aged up to 3 years, and during pregnancy   and breast-feeding .

Precautions should be taking medication for patients with adrenal insufficiency.

Side effects

Possible side effects:

• from the gastrointestinal tract - nausea, violation of stool, vomiting, pain   epigastric ;
• From the CCC - thrombocytopenia , Increased intracranial pressure;
• CNS - headache, photophobia, dizziness ;
• allergies   - itching . hives , Rash, in rare cases nasal allergy .

In addition, some patients were observed and adverse effects such as menstrual disorders, hair loss, paresthesia . impotence . gynecomastia .

The local application may cause irritation, burning, itching at the site of application of the drug. Shampoo Dermazol can produce side effects such as hair loss and / or change of hair color.

If you experience side effects is an urgent need to stop the use of drugs and seek medical advice.

Instructions on Dermazol (method and dosage)

Pills   adults and children weighing more than 30 kg administered at a dose of 200-400 mg per day. Children weighing less than 30 kg - 4-8 mg / kg per day. Medication taken 1 time a day during meals. Duration of treatment is determined by a physician. For example, fungal infections of the course is from 2 to 6 weeks, with Candida infections   skin and oral mucosa - 2-3 weeks at onihomikozah   - From six months to a year, if the system mycosis   - From 1-6 months, and at pityriasis versicolor - 10 days. After the disappearance of the symptoms of the medication should be continued for at least a week.

In addition, it is recommended to use the drug in the same time to ensure that the concentration of active substance in plasma was stable. If a pill for whatever reason, is postponed until the next time the reception is less than 4 hours to take the next pill.

For local and topical guide to Dermazol provides dosage and duration of the course, depending on the evidence and applied dosage form.

Cream for topical application   Lesion applied 1-2 times per day. With Candida infections   skin, as well as pityriasis versicolor   Course application is designed for 3-4 weeks. When seborrheic dermatitis   ointment applied 2-4 weeks. Before and after its application, it is desirable to wash your hands well.

Instructions on Shampoo Dermazol   it involves applying a wet clean hair. It is necessary to leave the vehicle for a few minutes and then thoroughly rinse the hair. The shampoo is used 1 time per day. A course of treatment tinea versicolor   in this case it is intended for 5 days. To get rid of seborrheic dermatitis   agent is used within 3 days. For the treatment and prevention Dandruff   Shampoo Dermazol used 1 every 1-2 weeks.

Overdose

Overdosing is possible only drug when administered orally. In this case there is nausea . headache . vomiting . dizziness . Too high doses may cause spasms   and   prickle .

Use of the drug should be discontinued immediately. Patients underwent gastric lavage, chelators . Treatment is symptomatic.

Cooperation

Carefully monitor the dosage needed while applying it to antacid   means, as because they reduce the absorption of active substances from the blood.

Also the bioavailability of the drug may be reduced due to a combination with powerful inducers of CYP3A4 : Isoniazid . Rifampicin . Phenytoin . Nevirapine . Rifabutin . Carbamazepine . Efavirenz . The dosage of the drug should be strictly monitored and adjusted if necessary.

Powerful inhibitors of CYP3A4 Conversely, in some cases, increase the bioavailability of the drug. Treatment should be under medical supervision. If necessary, the dosage is reduced.

Dermazol can inhibit CYP3A4-mediated metabolism   drugs. This affects the efficiency and strength of their action.

Simultaneously with this drug is not recommended to take the following medications: Tamsulosin . Rifabutin .   Carbamazepine . Nilotinib . Salmeterol . Fentanyl . Rivaroxaban . Dasatinib . Trabectedin . If this can not be avoided, careful monitoring of the patient, in time to eliminate the risk of side effects. If necessary, the dosage of drugs are reduced.

With caution should be combined with ketoconazole medicines such as: Alfentanil . Oxycodone . Coumarins . Repaglinide . Praziquantel . Eletriptan . Busulfan . Erlotinib . Ixabepilone . Trimetrexate . Alprazolam . Brotizolam . Haloperidol . Perospiron . Ramelteron . Maraviroc . Saquinavir . verapamil . Aprepitant . Ciclesonide . Dexamethasone . Methylprednisolone . Tacrolimus . Atorvastatin . Fesoterodine . Sildenafil . Tadalfil . Alitretinoin   (p.o.) Mozavaptan .

Careful monitoring of the patient is also required in a joint application with Dermazola Buprenorphine . Digoxin . Cilostazol . Saxagliptin . Ebastine . Bortezomib . Docetaxel . Imatinib . Lapatinib . vinca alkaloids . Aripiprazole . Buspirone . Midazolam   (internal administration) Quetiapine . Risperidone . Indinavir . Nadolol . Aliskiren . Budesonide . Cyclosporine . Fluticasone . Sirolimus . Temsirolimus . Reboxetine . Imidafenatsinom . Solifenacin . Tolterodine . Cinacalcet   and Tolvaptanom .

If necessary, the dosages are adjusted.

Terms of sale

The drug is sold strictly on prescription.

Storage conditions

Store this medication should be in a dry, dark place at room temperature.

Shelf life

Regardless of the form of issue, expiration date medicines - 3 years.

Reviews Dermazole

Numerous accolades about Dermazole indicate that the facility is really effective for treatment candidiasis . Dandruff . fungal infections skin and other fungal diseases. With its objectives it is fully cope. Very often you can find reviews of shampoo Dermazol as an excellent remedy against dandruff. Many say that it is not cheap, but effective.

Price Dermazola where to buy

Price Dermazola pharmacies may be very different. Much depends on the form of the drug. So the price shampoo Dermazol   50 ml is about 220 rubles. Cost ointment   30 grams - an average of 180 rubles.

Honey and infrequent type of issue - pills . Cost Dermazola for oral use - about 260 rubles.

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The fewer calories, the longer life

March 21 2014

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People who prefer eating low-calorie dishes, live longer. This is the conclusion of scientists Australia I am trying to determine how calorie foods affect the human life span.

If the number of calories each day enter the human body decreases gradually reduced and energy expenditure, metabolic processes are also slower. Accordingly, it also slows down the aging process.

Studies to confirm this theory, carried out in the world more than once. In the United States in the thirties of the last century was an experiment with laboratory rats. They were fed only low-calorie foods. As a result, the animals were able to live much longer than their relatives, eating familiar food. Rats that " comply " diet , Lived about 1,800 days, which, by the standards of the person equals approximately 200 years .

At the same time, the results of recent research scientists Australia   suggests that diet and length of life are closely interconnected. If a person in a certain measure restricts itself to the diet, the body uses the nutrient reserves that have been accumulated for future use. This in turn improves the recovery process DNA   in case it is damaged. As a result, not only the body ages more slowly, but also more effectively resists the development of   oncological diseases .

By the way, the Scientific Council from time to time to comply with the special " liquid "Diet. To do this for a week to eat only liquid food - soups . liquid mash . smuzzi . juices . dairy products   and others. This food helps clean the intestines, improves digestion. In addition, scientists assure that those who regularly eats only liquid food, improves blood. The blood becomes more fluid, thus reducing the risk of blood clots .

However, these principles should not adhere to supply more than one week. Nor should we observe this diet for pregnant women. And for those who for some reason is not able to sustain such a diet a few days, it is recommended at least once a day to eat fresh soup or borsch.

Traumeel S

Description overdue on 08.10.2011

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Homeopathic medicine. It has anti-inflammatory, anti-inflammatory, analgesic, reparative, immunokorrektiruyuschim action . Traumeel S activates the body's own tread. In its composition of matter comprising the mineral, vegetable origin. Traumeel S inhibits the development of edema Inhibits hemorrhage   when damaged soft tissues. Effectively relieves pain, lowers the permeability of blood vessels, increases their tone, normalizes blood clotting. Wound healing (regenerating) the effect of the drug is widely used in patients after surgery. The drug activates Th-lymphocyte clone, starts an auxiliary immune response, which in the hearth recovering balance between pro-inflammatory and anti-inflammatory cytokines. With prolonged use of corticosteroids Traumeel S reduces their dosage, increase the effectiveness of combined therapy. It is a universal anti-inflammatory drugs .

Dosage Form:

Pills. Drops. Ointment. Solution for injection.

Indications:

Degenerative, inflammatory processes in organs and tissues, injury   musculoskeletal system, soft tissue, brain concussion, hemophthalmus, periodontal disease , Bleeding in the retina, periodontitis, phlebeurysm . hemorrhoids Gingivitis, bursitis , Arthritis, synovitis, gout . ankylosing spondylitis , The effects of generic tramatizma, infectious complications after surgery, epicondylitis, tenosynovitis, styloiditis   and etc.

Contraindications:

Allergies.

Side effect:

Arthralgia , Hypersalivation, allergies.

Mode of application:

Drops: 10 drops three times a day inside. When edema - 30 drops on protseuru. Tablekti: by 1t. Three times per day sublingually. Ointment: rubbing the affected area two times a day, can bandage. Do not apply ointment Traumeel S to large areas of skin. Injection: intra, n / a, / m, w / 1-2 ampoule 1-3 times a week. In exacerbations - often.

Overdose:

The cases are not registered.

Special instructions:

With the development of hypersalivation   you must stop the use of Traumeel S. Drops contains ethanol   (35%). The ointment is not applied to vast areas.

Drug Interactions:

Compatible with other drugs in the complex treatment.

Genferon

Description overdue on 05/14/2014

• Latin name: Genferone
• ATC code: L03AB05
• Active substance: Recombinant human interferon alpha-2b (Interferon alfa-2b)
• Manufacturer: JSC "Biocad" Russian

Photos of the drug

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on candles Genferon
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Candles Genferon children
• With alcohol
• With antibiotics
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

1 suppository (suppository) contains: recombinant human interferon alpha-2b   - 500000 IU or 1,000,000 IU (depending on dose) Taurine   - 10, 0 mg benzocaine   - 55, 0 mg.

Excipients: macrogol 1500 . dextran 60000 . polysorbate 80 . citric acid . emulsifier T2 . sodium hydrocitrate , Hard fat, purified water.

Product form

Sparkling white or pale yellow. They have a cylindrical shape, a pointed end on a longitudinal section of uniform, but allowed the presence of air inclusions.

It is produced in cardboard packets within a single packet 1 or 2 outline package containing 5 suppositories.

Pharmacological action

Genferon has immunomodulatory, antiproliferative, antibacterial, antiviral, Valium, regenerating effect.

Pharmacodynamics and pharmacokinetics

The combined action caused Genferon components in its composition, which have a local and systemic effect.

The composition is Genferon Recombinant human interferon alpha-2b . It is synthesized by genetically modified strains of microorganisms Escherichia coli.

Interferon alfa-2b   It is immunomodulator And provides antiproliferative . antivirus and Antibacterial action . These effects are caused by stimulatory effect of the drug on intracellular enzymes that inhibit viral reproduction. Interferon enhances cell-mediated immunity through the activation of a number of markers of NK cells, accelerating the division   B-lymphocyte   and synthesis of antibodies, increasing the activity of monocyte-macrophage system and improve recognizability infected and tumor cells. As a result of this increased efficiency of the body fight against viruses, bacteria, parasites and tumor cells. Also under the influence of interferon is activated leukocytes   mucosal involved in the suppression of lesions.

Taurine   normalises metabolic processes in the tissues, promotes regeneration, reacts with free oxygen radicals, neutralizing them and preventing tissue damage. Interferon is less susceptible to decay and longer remains in effect due to the presence of taurine.

Benzocaine (benzocaine) - Local anesthetic. It modifies the permeability of the cytoplasm of neurons for sodium and calcium ions, resulting in not only blocks the nerve impulses along axons, but also inhibited the process of occurrence of nerve impulses. Benzocaine has only a local effect, and is not absorbed into the systemic circulation.

When rectal Genferon bioavailability   It reaches more than 80%. This allows both local and express immunomodulatory effects throughout the body. For vaginal application, due to the high concentration of the drug in the infected site and its attachment to the mucous cells achieved a notable local antiviral, antibacterial and anti-proliferative effect, but in this case the systemic effect (due to the low absorption capacity of mucous internal genitalia) is negligible. The maximum concentration of interferon in the blood is detected after 4-6 hours after treatment. Write mainly kidneys. The half-life   It is 12 hours, which makes it necessary to use the preparation two times a day.

Indications

Indications spark Genferon assumes rectal or vaginal (at dosages of 500 thousand. IU or 1 million. ME) their use, by which a treatment corresponding uncomplicated disease in children use the same name for children candles (Genferon Light), and their analogs in various forms (e.g. an ointment, a syrup or tablet).

In other cases Genferon used in treatment for diseases genitourinary system   infectious and inflammatory nature in adults:

• chlamydia;
• genital herpes;
• mycoplasmosis;
• ureaplasmosis;
• bacterial vaginosis;
• HPV infection;
• trichomoniasis;
• cervical erosion;
• bacterial vaginosis;
• vulvovaginitis;
• cervicitis;
• adnexitis;
• urethritis;
• bartholinitis;
• balanitis;
• prostatitis;
• balanoposthitis.

It is also justified by the use of medication for thrush ( vaginal candidiasis ).

Contraindications

Increased sensitivity to interferon or other substances in the composition of the preparation is a contraindication to its use. Drug treatment is unacceptable for the first 12 weeks of pregnancy. Also it should be used with caution in patients with Genferon exacerbations of diseases of the immune system.

Side effects

In drug treatment at a dose 10000000 IU per day, and more increases the possibility of the following side effects:

• headache - from CNS ;
• leukopenia, thrombocytopenia   - By hematopoietic system ;
• systemic reactions ( hyperthermia , Increased sweating, fatigue, pain in muscles and joints, poor appetite).

You may experience allergic reactions: skin rash, itching. These symptoms are reversible and disappear within 72 hours after discontinuation of the drug.

Instructions on candles Genferon

Instructions for use Genferon explains that the length of treatment, dosage and route of administration are determined by the attending physician and depend on the particular disease. Instructions for use of candles Genferon and instruction to children Genferon almost identical to the proposed scheme of the drug. However, children are not always suitable rectal or vaginal route of administration of the drug, so in some cases it is worth considering to move to analogues Genferon with other routes of administration (tablets, ointment, syrup).

The drug is used vaginally or rectally .

In the treatment of infectious diseases of the genitourinary system, inflammatory recommended for women administered 1 suppository (500000 IU or 1,000,000 IU dependent form of the disease), rectally or vaginally (depending on the form of the disease) 2 day daily for 10 days. With a long and chronic forms, the introduction of a day to 1 candle. In this case, the treatment will be between 1 to 3 months.

Application 1 suppository (500,000 IU) vaginally morning and one suppository (1,000,000 IU) rectally in the evening at the same time intravaginal suppository using antibacterial justified in serious infectious-inflammatory process in internal genital organs .

Treatment of diseases of the urogenital tract infectious inflammatory men reduced to the following regimen: rectally applicable 1 suppository (dosage depends on the form of the disease), 2 times a day for 10 days.

Overdose

To date, no data on overdose Genferon. If by chance it was introduced at the same time a large number of candles, you must stop using the drug on the day. After this time, you can re-start the application on the designated Genferon scheme.

Cooperation

Vitamins C and   E   enhance the effect of the components Genferon. Benzocaine   reduces the bactericidal and bacteriostatic activity sulfonamides . Non-narcotic analgesics   often enhance the effect of benzocaine .

Terms of sale

In Russia and Ukraine Genferon available over the counter only on prescription.

Storage conditions

The drug should be stored out of reach of children a dark place in a temperature range 2- 8 ° C.

Shelf life

Shelf life - 24 months. Do not use medication after the expiration date (printed on).

Cautions

Genferon most effective while the use of antimicrobial drugs.

On the safety of using the drug in the month there is no reliable data. Therefore, you should use the drug with caution during menstruation.

Analogs Genferon

Match code ATC 4th level:

• Interferon
• Nazoferon
• Viferon
• Infagel
• IFN-EU-Lipint
• IFN-EU
• IFN-Lipint
• Altevir
• Algeron
• Genferon Light
• Grippferon

Immediately it should be noted that it is often presented in our pharmacies analogues of Genferon cheaper and in most cases reasonable price analogs relates to their Ukrainian origin.

So, what can replace candles Genferon:

• full analogs of the active substance and the form of - Vitaferon, Viferon, Viferon-Fearon, Laferobion, Laferon Farmbiotek, Kipferon ;
• analogs of the active substance - Alfarekin, ALFARON, Bioferon, Virogel, Gerpferon, Grippferon, Introbion interferon alfa-2b, Intron A, Interoferobion interferon alfa-2b, Laferon Farmbiotek, Lipoferon, Okoferon, Realdiron   and others.

Candles Genferon children

For children, the instructions for use of the drug does not impose age restrictions on its use. However, antiviral candles for children under 7 years (babies included) are best used in a dosage of 125,000 IU and children 7 years and older - at a dose of 250,000 IU, which corresponds to the release form of the drug called Genferon Light.

Compatible with alcohol

No data on the influence of alcohol and sharing Genferon, but in the treatment of a number of commonly used antimicrobials, which alcohol is not compatible. It is therefore recommended to give up alcohol during treatment Genferon as part of a multi-component therapy.

With antibiotics

Genferon more effective when used simultaneously with antibacterial drugs.

Candles Genferon during pregnancy

Guide speaks of the necessity of relating the benefits of drug treatment and the risk to the fetus, if necessary, use Genferon. Although in most cases the use of the drug causes a positive feedback during pregnancy.

In the second and third trimesters of pregnancy (13-40 weeks) application is shown as part of a multi-component therapy chlamydia, genital herpes, ureaplasmosis, cytomegalovirus infection, mycoplasma, human papillomavirus infection, bakvaginoza   when symptoms of discomfort, itching and other sensations in the lower urinary tract.

Reviews Genferon

In general, reviews of candlelight Genferon that can be read on a variety of forums, ranging from neutral to positive.

Many comments and questions is combination therapy (especially vaginal suppositories) viral diseases of the genitourinary system in women: Human Papilloma Virus (HPV), cytomegalovirus, herpes virus . The most common of the effectiveness of treatment, patients reported that doctors prescribe therapy with candle 1000000 IU for the treatment of HPV.

Frequent reports of periodic rise in temperature and the deterioration of health during use candles with " adults "Dosages in children (not recommended instructions).

It should be noted that the question of the proper use of the drug during pregnancy should be addressed directly to the doctor.

Often the question is raised about the comparative effectiveness Genferon and its analogs, such as:

Is it better or Kipferon Genferon?

Kipferon   and Genferon, which differ not only in composition but also in the testimony, often prescribed in the treatment of diseases of the genitourinary system, the views of patients lean toward greater efficiency of the latter.

Is it better or Viferon Genferon?

Objectively, it may be noted slight differences Viferon and Genferon in preparations (Viferon contains vitamin C, protects the interferon by rapid denaturation in the rectum), but otherwise they are identical (indications and treatment regimens), and the opinions of inhabitants are based more on feedback from friends and acquaintances, than on proven facts of the use of these drugs.

Price Genferon

For Russia, the average price of candles Genferon 1 million. ME - 490 rubles and 500 thousand candles. IU cost about 370 rubles. Depending on the region and no significant razbezhek in price, for example, in Moscow, 500,000 IU Genferon price ranges from 340 to 380 rubles, and Omsk - from 360 to 370 rubles.

Ukraine offers us higher prices for the respective products. What is the cost to buy in Genferon Ukrainian pharmacy? Purchase cost about 2 times more expensive than in Russia, and will be for 1,000,000 IU Genferon an average of 190 hryvnia. Price 500,000 IU dose of the candle close to 160 UAH.

Patients do not always suit the rectal and vaginal routes of administration of the drug and, in some cases, the spark may be replaced by tablets, ointments or injections similar composition.

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