Description overdue on 05/14/2014
- Latin name: Genferone
- ATC code: L03AB05
- Active substance: Recombinant human interferon alpha-2b (Interferon alfa-2b)
- Manufacturer: JSC "Biocad" Russian
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on candles Genferon
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Candles Genferon children
- With alcohol
- With antibiotics
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
1 suppository (suppository) contains: recombinant human interferon alpha-2b - 500000 IU or 1,000,000 IU (depending on dose) Taurine - 10, 0 mg benzocaine - 55, 0 mg.
Excipients: macrogol 1500 . dextran 60000 . polysorbate 80 . citric acid . emulsifier T2 . sodium hydrocitrate , Hard fat, purified water.
Product form
Sparkling white or pale yellow. They have a cylindrical shape, a pointed end on a longitudinal section of uniform, but allowed the presence of air inclusions.
It is produced in cardboard packets within a single packet 1 or 2 outline package containing 5 suppositories.
Pharmacological action
Genferon has immunomodulatory, antiproliferative, antibacterial, antiviral, Valium, regenerating effect.
Pharmacodynamics and pharmacokinetics
The combined action caused Genferon components in its composition, which have a local and systemic effect.
The composition is Genferon Recombinant human interferon alpha-2b . It is synthesized by genetically modified strains of microorganisms Escherichia coli.
Interferon alfa-2b It is immunomodulator And provides antiproliferative . antivirus and Antibacterial action . These effects are caused by stimulatory effect of the drug on intracellular enzymes that inhibit viral reproduction. Interferon enhances cell-mediated immunity through the activation of a number of markers of NK cells, accelerating the division B-lymphocyte and synthesis of antibodies, increasing the activity of monocyte-macrophage system and improve recognizability infected and tumor cells. As a result of this increased efficiency of the body fight against viruses, bacteria, parasites and tumor cells. Also under the influence of interferon is activated leukocytes mucosal involved in the suppression of lesions.
Taurine normalises metabolic processes in the tissues, promotes regeneration, reacts with free oxygen radicals, neutralizing them and preventing tissue damage. Interferon is less susceptible to decay and longer remains in effect due to the presence of taurine.
Benzocaine (benzocaine) - Local anesthetic. It modifies the permeability of the cytoplasm of neurons for sodium and calcium ions, resulting in not only blocks the nerve impulses along axons, but also inhibited the process of occurrence of nerve impulses. Benzocaine has only a local effect, and is not absorbed into the systemic circulation.
When rectal Genferon bioavailability It reaches more than 80%. This allows both local and express immunomodulatory effects throughout the body. For vaginal application, due to the high concentration of the drug in the infected site and its attachment to the mucous cells achieved a notable local antiviral, antibacterial and anti-proliferative effect, but in this case the systemic effect (due to the low absorption capacity of mucous internal genitalia) is negligible. The maximum concentration of interferon in the blood is detected after 4-6 hours after treatment. Write mainly kidneys. The half-life It is 12 hours, which makes it necessary to use the preparation two times a day.
Indications
Indications spark Genferon assumes rectal or vaginal (at dosages of 500 thousand. IU or 1 million. ME) their use, by which a treatment corresponding uncomplicated disease in children use the same name for children candles (Genferon Light), and their analogs in various forms (e.g. an ointment, a syrup or tablet).
In other cases Genferon used in treatment for diseases genitourinary system infectious and inflammatory nature in adults:
- chlamydia;
- genital herpes;
- mycoplasmosis;
- ureaplasmosis;
- bacterial vaginosis;
- HPV infection;
- trichomoniasis;
- cervical erosion;
- bacterial vaginosis;
- vulvovaginitis;
- cervicitis;
- adnexitis;
- urethritis;
- bartholinitis;
- balanitis;
- prostatitis;
- balanoposthitis.
It is also justified by the use of medication for thrush ( vaginal candidiasis ).
Contraindications
Increased sensitivity to interferon or other substances in the composition of the preparation is a contraindication to its use. Drug treatment is unacceptable for the first 12 weeks of pregnancy. Also it should be used with caution in patients with Genferon exacerbations of diseases of the immune system.
Side effects
In drug treatment at a dose 10000000 IU per day, and more increases the possibility of the following side effects:
- headache - from CNS ;
- leukopenia, thrombocytopenia - By hematopoietic system ;
- systemic reactions ( hyperthermia , Increased sweating, fatigue, pain in muscles and joints, poor appetite).
You may experience allergic reactions: skin rash, itching. These symptoms are reversible and disappear within 72 hours after discontinuation of the drug.
Instructions on candles Genferon
Instructions for use Genferon explains that the length of treatment, dosage and route of administration are determined by the attending physician and depend on the particular disease. Instructions for use of candles Genferon and instruction to children Genferon almost identical to the proposed scheme of the drug. However, children are not always suitable rectal or vaginal route of administration of the drug, so in some cases it is worth considering to move to analogues Genferon with other routes of administration (tablets, ointment, syrup).
The drug is used vaginally or rectally .
In the treatment of infectious diseases of the genitourinary system, inflammatory recommended for women administered 1 suppository (500000 IU or 1,000,000 IU dependent form of the disease), rectally or vaginally (depending on the form of the disease) 2 day daily for 10 days. With a long and chronic forms, the introduction of a day to 1 candle. In this case, the treatment will be between 1 to 3 months.
Application 1 suppository (500,000 IU) vaginally morning and one suppository (1,000,000 IU) rectally in the evening at the same time intravaginal suppository using antibacterial justified in serious infectious-inflammatory process in internal genital organs .
Treatment of diseases of the urogenital tract infectious inflammatory men reduced to the following regimen: rectally applicable 1 suppository (dosage depends on the form of the disease), 2 times a day for 10 days.
Overdose
To date, no data on overdose Genferon. If by chance it was introduced at the same time a large number of candles, you must stop using the drug on the day. After this time, you can re-start the application on the designated Genferon scheme.
Cooperation
Vitamins C and E enhance the effect of the components Genferon. Benzocaine reduces the bactericidal and bacteriostatic activity sulfonamides . Non-narcotic analgesics often enhance the effect of benzocaine .
Terms of sale
In Russia and Ukraine Genferon available over the counter only on prescription.
Storage conditions
The drug should be stored out of reach of children a dark place in a temperature range 2- 8 ° C.
Shelf life
Shelf life - 24 months. Do not use medication after the expiration date (printed on).
Cautions
Genferon most effective while the use of antimicrobial drugs.
On the safety of using the drug in the month there is no reliable data. Therefore, you should use the drug with caution during menstruation.
Analogs Genferon
Interferon
Nazoferon
Viferon
Infagel
IFN-EU-Lipint
IFN-EU
IFN-Lipint
Altevir
Algeron
Genferon Light
Grippferon
Immediately it should be noted that it is often presented in our pharmacies analogues of Genferon cheaper and in most cases reasonable price analogs relates to their Ukrainian origin.
So, what can replace candles Genferon:
- full analogs of the active substance and the form of - Vitaferon, Viferon, Viferon-Fearon, Laferobion, Laferon Farmbiotek, Kipferon ;
- analogs of the active substance - Alfarekin, ALFARON, Bioferon, Virogel, Gerpferon, Grippferon, Introbion interferon alfa-2b, Intron A, Interoferobion interferon alfa-2b, Laferon Farmbiotek, Lipoferon, Okoferon, Realdiron and others.
Candles Genferon children
For children, the instructions for use of the drug does not impose age restrictions on its use. However, antiviral candles for children under 7 years (babies included) are best used in a dosage of 125,000 IU and children 7 years and older - at a dose of 250,000 IU, which corresponds to the release form of the drug called Genferon Light.
Compatible with alcohol
No data on the influence of alcohol and sharing Genferon, but in the treatment of a number of commonly used antimicrobials, which alcohol is not compatible. It is therefore recommended to give up alcohol during treatment Genferon as part of a multi-component therapy.
With antibiotics
Genferon more effective when used simultaneously with antibacterial drugs.
Candles Genferon during pregnancy
Guide speaks of the necessity of relating the benefits of drug treatment and the risk to the fetus, if necessary, use Genferon. Although in most cases the use of the drug causes a positive feedback during pregnancy.
In the second and third trimesters of pregnancy (13-40 weeks) application is shown as part of a multi-component therapy chlamydia, genital herpes, ureaplasmosis, cytomegalovirus infection, mycoplasma, human papillomavirus infection, bakvaginoza when symptoms of discomfort, itching and other sensations in the lower urinary tract.
Reviews Genferon
In general, reviews of candlelight Genferon that can be read on a variety of forums, ranging from neutral to positive.
Many comments and questions is combination therapy (especially vaginal suppositories) viral diseases of the genitourinary system in women: Human Papilloma Virus (HPV), cytomegalovirus, herpes virus . The most common of the effectiveness of treatment, patients reported that doctors prescribe therapy with candle 1000000 IU for the treatment of HPV.
Frequent reports of periodic rise in temperature and the deterioration of health during use candles with " adults "Dosages in children (not recommended instructions).
It should be noted that the question of the proper use of the drug during pregnancy should be addressed directly to the doctor.
Often the question is raised about the comparative effectiveness Genferon and its analogs, such as:
Is it better or Kipferon Genferon?
Kipferon and Genferon, which differ not only in composition but also in the testimony, often prescribed in the treatment of diseases of the genitourinary system, the views of patients lean toward greater efficiency of the latter.
Is it better or Viferon Genferon?
Objectively, it may be noted slight differences Viferon and Genferon in preparations (Viferon contains vitamin C, protects the interferon by rapid denaturation in the rectum), but otherwise they are identical (indications and treatment regimens), and the opinions of inhabitants are based more on feedback from friends and acquaintances, than on proven facts of the use of these drugs.
Price Genferon
For Russia, the average price of candles Genferon 1 million. ME - 490 rubles and 500 thousand candles. IU cost about 370 rubles. Depending on the region and no significant razbezhek in price, for example, in Moscow, 500,000 IU Genferon price ranges from 340 to 380 rubles, and Omsk - from 360 to 370 rubles.
Ukraine offers us higher prices for the respective products. What is the cost to buy in Genferon Ukrainian pharmacy? Purchase cost about 2 times more expensive than in Russia, and will be for 1,000,000 IU Genferon an average of 190 hryvnia. Price 500,000 IU dose of the candle close to 160 UAH.
Patients do not always suit the rectal and vaginal routes of administration of the drug and, in some cases, the spark may be replaced by tablets, ointments or injections similar composition.
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