Description overdue on 08/12/2014
- Latin name: Pregabalin Richter
- ATC code: N03AX16
- Active substance: Pregabalin (Pregabalin)
- Manufacturer: Of OJSC "Gedeon Richter» (Hungary), CJSC "Gedeon Richter-RUS» (Russia)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Pregabalin Pregabalin and Richter
- Contraindications
- Side effects
- Pregabalin, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
In audio capsule contains active substance - pregabalin 25-300 mg, and auxiliary components: lactose monohydrate, corn starch, talc .
The composition of the body of a gelatin capsule include: titanium dioxide, quinoline yellow dye, colorant sunset yellow and gelatin.
Product form
Drug is manufactured in the form capsules according to 25, 50, 75, 100, 150, 200 and 300 mg active substance. The capsules are packaged in blister pack of 14 pieces and packed by 1 or 4 blisters.
Pharmacological action
Pregabalin has anticonvulsant and analgesic effect.
Pharmacodynamics and pharmacokinetics
Active ingredient - pregabalin It exhibits significant analgesic and anticonvulsant effect. Course reception of the drug helps reduce pain symptoms diabetic neuropathy, postherpetic neuralgia and fibromyalgia.
Treatment of pregabalin in epilepsy It helps to reduce the frequency of seizures in the first week. Around the same period, it noted a decrease in unwanted symptoms in generalized anxiety disorder.
When an internal reception of pregabalin absorption is fast enough. Maximum plasma concentration is reached within 1 hour, regardless of the multiplicity of application.
Addicting food can be reflected in concentration of the active substances, lowering it on the 25-30%, but it is not produces clinically significant effect on the total the absorption of.
Inside the body almost Pregabalin is not bound to plasma proteins and is not subject to metabolize .
The bulk of the substance excreted unchanged by the kidneys. If patients have impaired renal function, and they are on hemodialysis, they require dose adjustment.
During the re-use to predict the pharmacokinetics pregabalin According possible after receiving a single dose. This allows us not to carry out regular monitoring of the concentration of a substance in the blood plasma.
Indications Pregabalin Pregabalin and Richter
The main indications for use are:
- neuropathic pain;
- generalized anxiety disorder;
- fibromyalgia;
- epilepsy - If necessary, add-on therapy for patients with partial seizures, which may be accompanied by secondary generalization.
Contraindications
Do not take this medicine if:
- hypersensitivity to any component;
- rare hereditary diseases such as intolerance to galactose, lactase deficiency, and others;
- patients aged under 17 years.
In addition, care must be taken in the appointment of pregabalin in patients with renal or Heart Failure , Having medicinal dependence in the anamnesis. Treatment of such patients should be under close medical supervision.
Side effects
In the treatment of pregabalin often develop such adverse events as dizziness and drowsiness . They usually is mild or moderate form. In addition, there are often side effects requiring discontinuation of the drug: ataxia, fatigue, confusion, blurred vision, impaired attention and coordination, peripheral edema.
It should be noted that these undesirable phenomena can be related to major diseases or therapy.
Pregabalin, instructions for use (method and dosage)
This product is intended for indoor reception, regardless of the use of food. The daily dose can be 150-600 mg, designed for 2-3 hours.
As informs instruction on the application Pregabalin Richter, in the treatment of neuropathic pain, epilepsy, fibromyalgia and generalized anxiety disorder usually prescribed initial daily dose of 150 mg. After 3-7 days, depending on the efficacy and tolerability of the drug, the daily dose may be increased to 300 mg. If necessary, further treatment after 7 days, the dose can be increased to a maximum of 600 mg per day.
By the abolition of pregabalin should be approached with particular responsibility. To do this, reduce the dosage gradually, continuing to take the drug for at least a week.
Treatment of elderly patients with impaired renal function It requires individual selection of dosage for age, sex and body weight.
If was skipped reception of medications, we need faster to adopt the following dose. However, to take the drug in a double dosage is not recommended. The next day, should resume normal reception capsules.
Overdose
When pregabalin overdose may develop:
- affective disorders;
- drowsiness;
- confusion;
- doldrums;
- agitation and concern.
Such cases require a gastric lavage, maintenance therapy, and sometimes hemodialysis.
Cooperation
It was found that mostly Pregabalin appears unchanged by the kidneys, subjected to minimum metabolism in the human body does not come into contact with blood plasma proteins. For these reasons, its ability to pharmacokinetic interaction is greatly reduced.
However, there were cases when patients simultaneously taking Pregabalin and CNS depressants drugs Against the background of what happened respiratory insufficiency and coma .
Possible negative effect of the drug on the function of the gastrointestinal tract, appealing ileus . paralytic ileus , If his simultaneously taken with medications, causing constipation , eg, opioid analgesics .
Terms of sale
Pregabalin prescription.
Storage conditions
To store the drugs needed a cool, dry place, away from children reliably protected.
Shelf life
2 years.
Analogs of pregabalin
Keppra
Tebantin
The main counterparts of the drug are Algerika and Lyric poetry . The price of analogues based on the content of the basic substance, and the number of tablets in the package varies from 212 to 4700 rubles.
Alcohol and Pregabalin
It is established, that all preparations on the basis of pregabalin significantly enhance the action of of alcohol. Therefore, during the treatment of drinking should be abandoned.
Reviews of pregabalin
Online you can find many reviews about Pregabalin Richter and other drugs with the same active ingredient. These tools are quite common in clinical practice and are often prescribed by specialists for the treatment of neuropathic pain . However, if the disease is found in patients suffering also diabetes , It is more effective Pregabalin lyrics.
Of course, the reception and the drug does not exclude the development of side effects, such as: nausea and dizziness Which may occur at the beginning of therapy. So often, doctors recommend taking the drug at night.
In any case, to choose the drug should not be. You need to see a doctor who will be able to appoint a competent treatment.
Price pregabalin, where to buy
Buy preparations on the basis of pregabalin It can be a prescription at any pharmacy Russia. The price Richter Pregabalin 150 mg of 360-400 rubles.
No comments:
Post a Comment