Kestin

Description overdue on 08/25/2014

• Latin name: Kestine
• ATC code: R06AX22
• Active substance:   Ebastine (Ebastine)
• Manufacturer: Nycomed Danmark ApS (Denmark)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Kestin
• Contraindications
• Side effects
• Kestin - Instructions for use
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Reviews
• Price, where to buy
• Kestin.ru (kestine.ru)

Composition

Various dosage forms Kestin have the following composition:

• Kestin tablets coated foil - 1 tablet contains 20 mg of active substance ( ebastine ) And adjuvants: magnesium stearate . microcrystalline cellulose . pregelatinized corn starch . lactose monohydrate . Croscarmellose sodium . Valium . titanium dioxide . Macrogol 6000 ; of the shell comprises: hydroxypropylmethylcellulose, polyethylene glycol 6000, titanium dioxide;
• Kestin tablets coated foil - 1 tablet contains 10 mg of active substance ( ebastine ) And auxiliaries and composition of the shell is the same as in tablets of 20 mg;
• Tablets Kestin Lyophilized   (for dissolution in the oral cavity) - 1 tablet contains 20 mg of active substance ( ebastine ) And adjuvants:   gelatin . mannitol . Aspartame . mint flavor ;

Product:

• Round white pills in the shell of a film with an engraving "E20" on one side. Available in packaging made of cardboard (1 blister pack of 10 pieces).
• Round white pills in the shell of a film with an engraving "E10" on one side. Available in packaging made of cardboard (1 blister pack of 10 pieces).
• Round white pills in the shell of a film with an engraving "E10" on one side. Available in packaging made of cardboard (1 blister pack of 5 pieces).
• Round Lyophilized   (lozenge in the mouth) white tablets. Available in cardboard packaging of 10 pieces in one blister.

Pharmacological action

Kestin belongs to the group histamine receptor blockers N1- . Its main action - anti-allergic. The drug quickly relieves swelling of the tissues, reduces exudation , Prevents histamine-induced spasms of smooth muscles of the bronchi. Quickly and permanently removes associated allergies itching, burning skin and mucous membranes. Side sedation Kestin have virtually none.

Pharmacodynamics and pharmacokinetics

Active ingredient of the drug   Ebastine   blocks H1-histamine receptors Located in the tissues, which inhibits the reaction of organs and tissues for histamine .   H1-histamine receptors   located in the smooth muscles of viscera and blood vessel walls. When interacting with these receptors, histamine causes the contraction of smooth muscle of the above, increases vascular permeability, promotes the formation of mucus and nasal glands, as well as biologically active substances involved in the development of allergic reactions.

Ebastine prevents and reduces all effects caused by histamine, prevents the development of allergic edema, reduces redness, burning and itching, that is, prevent the development and facilitates the allergic reactions. The mechanism of action ebastine - is competing with histamine for interaction with   H1-histamine receptors organs and tissues. And as ebastine have an affinity for them less pronounced than that of histamine, it does not displace the latter and interacts only with the free and liberated receptors. Therefore ebastine works better as a preventive agent, while already begun allergic reaction is not so efficient.

Like all blockers   H1-histamine receptors   active agent has a sufficiently high affinity for H1-histamine receptors That provides a quick healing effect: after ingestion of the drug action comes after an hour and lasts for 48 hours. After a course of treatment-effect of the drug persists for three days due to the fact that the active metabolic products (metabolites) that are Ebastine decomposed in the liver, excreted slowly. Conclusion ebastine metabolites occurs via the kidney.

Indications Kestin

Treatment is carried out under the following diseases and conditions:

• at allergic   seasonal or year-round rhinitis or conjunctivitis, caused by any allergens;
• at hives   and angioedema Caused by any allergens, as well as physical factors (solar radiation, excessive heat, cold, etc.);
• for any other diseases and conditions caused by an increased content of histamine.

Contraindications for use Kestin

The drug is not prescribed:

• if hypersensitivity to substances within a part Kestin;
• during pregnancy   and baby feeding breast;
• children: coated tablets from the film - 12 years, tablets freeze-dried - up to 15 years;
• at phenylketonuria   - Lyophilized tablets.

With care prescribe a drug in violation of the kidneys and liver, as well as patients with a coronary heart disease   and hypokalemia . Since in some patients it can cause drowsiness and impaired concentration during the course of treatment they should not drive a car.

Side effects Kestin

The drug was well tolerated and rarely has side effects. However, they can be:

• the central nervous system is - headache . drowsiness   or insomnia . slackness . weakness . decreased performance ;
• from the gastrointestinal tract -   various digestive disorders . nausea .   stomach ache, dry mouth ;
• from the upper respiratory tract - runny nose, genyantritis . sinusitis;
• allergic reactions   - often in the form of urticaria .

Kestin - Instructions for use

Coated tablets of the film is taken orally once a day (reception may not be associated with a meal). Adults and adolescents 15 years after the drug is administered not more than 20 mg (1-2 tablets of 10 mg or ½ - 1 tablet of 20 mg). Teenagers 12-15 years appoint 10 mg (1 tablet of 10 mg or ½ tablet of 20 mg), 1 per day.

Instructions for use Kestin recommends lyophilized tablets for sucking in the mouth (laid on language, where the tablet quickly dissolves). Admission lozenges are not linked to food, to wash down the pills should not be. Assign lyophilized tablets adults and adolescents over 15 years in the same dosage as the coated tablets from the film. The tablets are fragile, so take them out of the blister should be cautious not to damage.

Overdose Kestin

In overdose Kestin enhanced all its side effects. In this case, you should immediately wash out the stomach, and drink a few tablets of activated charcoal. If the condition does not improve, you need to call an ambulance.

Kestin Interaction with other drugs

Tablets Kestin film coated incompatible:

• with antifungal drugs ( fluconazole . ketoconazole   and etc.) , Macrolide antibiotics   ( erythromycin . clarithromycin   et al.) and spirituous preparations - Because of higher concentration Kestin in blood and the risk of cardiac events;
• from antiasthmatic drug theophylline ;
• indirect anticoagulants ;
• antiulcer means   C imetidinom ;
• tranquilizer D iazepamom ;
• any spirituous   drugs.

Lyophilized tablets are incompatible with Ketoconazole   and   Erythromycin But can be used simultaneously with theophylline, indirect anticoagulants, cimetidine, diazepam and alcohol-containing medications.

Terms of sale

Kestin dispensed at the pharmacy without a prescription.

Storage conditions

All dosage forms Kestin should be stored in a dark, dry place inaccessible to children at temperature not exceeding 25 ° C.

Shelf life

The drug is stored for 3 years, subject to the above conditions.

Analogs Kestin

Match code ATC 4th level:

• Dramina
• Lordestin
• Lomilan
• Fenkarol
• Loratek
• Aerius
• Feksadin
• Claritin
• Telfast
• Loratadine
• Diazolin

Analogs - a variety of dosage formulations groups which are used to treat the same disease. Kestin analogs are drugs from the group:

• blockers H1-histamine receptors But having in its composition other active ingredients; This dimethindene ( Fenistil ), Diphenhydramine ( Diphenhydramine ) Mebhydrolin ( Diazolin , Dialin), promethazine ( Promethazine . Pipolfen ) Chloropyramine ( Suprastin, Supradin ), Clemastine ( Tavegil, Bravegil ) Acrivastine (Sempreks ), Astemizole ( Astelong . Astemizole . Gismanal, Mibiron, Stemiz ), Loratadine Zodak, Tsetrin, Allertek ( Claritin, Klargotil, Klavoristin, Clarifier, Loradin, loratadine, Tirlo et al.), cetirizine ( Zodak, Tsetrin, Allertek ) and others;
• Stabilizers fat cell membranes; This cromoglicic acid ( Intal, kromogeksal, Lekrolin et al.), nedocromil sodium ( Tayled Mint ); They prevent the release of histamine from mast cells and other mediators that provoke allergic reactions.

Reviews Kestin

Kestin widely used for the prevention and treatment of allergic diseases and conditions. Most of the reviews for this drug are positive: many Kestin helps to cope with seasonal and perennial allergic diseases.

Nevertheless, there are patients who do not Kestin came: he did not warn them develop allergic reactions and reduces their appearance. This feature antiallergic drugs is well known to doctors: they need to be individualized for each patient.

There are reviews that provide Kestin side effects   as slackness . sleepiness   and dry mouth . But such responses are rare, because most patients do not experience side effects from taking the recommended doses Kestin.

Price Kestin

Tablets Kestin price in Moscow:

• Kestin coated tablet of 20 mg film number 10 - from 390 to 479 rubles;
• Kestin coated tablet of 10 mg film number 10 - from 332 to 389 rubles;
• Kestin tablet sheathed in a film of 10 mg number 5 - from 183 to 213 rubles;
• Tablets Kestin lyophilized (resorption) 20 mg number 10 - from 436 to 519 rubles.

Kestin.ru (kestine.ru)

Manufacturer Kestin Japanese pharmaceutical company Takeda on its website dedicated to this drug, in addition to the detailed instructions and answers to questions on Kestin, carries pollen monitoring all regions of Russia (a project developed by Russian scientists, together with specialists of pharmaceutical company Takeda).

Kestin and pollen monitoring are closely linked, as the latter allows you to learn all about the flowering plants in all corners of our country. Precise information about flowering in a particular region of a plant that causes seasonal allergies (hay fever), allergic allow timely to go to a safer place or to refuse to go into dangerous areas. If you avoid contact with allergens is not possible, then come to the aid allergy drugs, including Kestin.

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