Sulatsillin

Description overdue on 19.12.2011

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An antibiotic is a semisynthetic penicillin. In its composition contains an antibiotic ampicillin   and beta-lactamase inhibitor Sulbactam . The mechanism of action is based on blocking the synthesis peptidoglycan   the cell wall of the microbe. Sulbactam enhances drug effect on resistant strains that produce beta-lactamase. Sulatsillin no effect on strains Pseudomonas aeruginosa , Enterobacteriaceae, Klebsiella strains, strains penitsillinazprodutsiruyuschie staphylococci . Available as a powder, lyophilisate for the preparation of a solution in a tablet form.

Indications:

Sulatsillin prescribed for the treatment of infectious diseases. Respiratory : empyema , Chronic bronchitis , Lung abscess. ENT organs : Otitis media, tonsillitis, sinusitis.   The urinary system : endometritis . prostatitis . urethritis .   cystitis , Pyelitis, pyelonephritis . Digestive system : salmonellosis . dysentery . Skin : Dermatitis . impetigo , Erysipelas. Bile duct : cholecystitis , Cholangitis. The drug is prescribed for scarlet fever , Peritonitis, meningitis , Sepsis, bacterial endocarditis, gonococcal infection In the postoperative period to prevent infections.

Contraindications:

Sulatsillin not use in breast-feeding, infectious mononucleosis, allergies, pregnancy, hepatic failure system, renal system.

Side effect:

Forming Organs : thrombocytopenia , Anemia, leukopenia. Nervous system   Digestive system : pseudomembranous enterocolitis   (rarely), diarrhea, loss of appetite, dyspepsia, increased liver enzymes. Perhaps the increase in urea azotemia. The injection site can be formed phlebitis . When long-term therapy is developed candidiasis Superinfection.

Mode of application:

Intravenously Sulatsillin introduced at a rate of 60-80 drops per minute at the injection jet is carried out for 5 minutes. Uncomplicated gonorrhea   - A single dose of 1, 5 grams. In the postoperative period: 1, 5-3 grams every 7 hours. Intramuscular injection of the drug is diluted in a solution of lidocaine 0, 5%. When intravenously Sulatsilli dissolved in a solution of dextrose, sodium chloride, 0, 9% in volume of 10-200 mL.

Special instructions:

If you are sensitive to penicillin develop cross allergic reactions to antibiotics cephalosporin series. Long-term use requires monitoring of hepatic, renal system of the blood. With the development of superinfection (because of insensitive microflora) requires a change of antibacterial agents. In the treatment of sepsis logged Jarisch-Herxheimer   (bacteriolysis).

Drug Interactions:

Sulatsillin incompatible with protein hydrolysates , Blood products, aminoglakozidami. Laxatives, Glucosamine , Antacids, food, aminoglycosides slow down and reduce absorption of the drug. Ascorbic acid is able to increase the absorption sulatsillina. Bacteriostatic agents have antagonistic effects and bactericidal antibiotics - synergistic effect. Sulatsillin enhances effective action anticoagulants It reduces the effectiveness of oral contraceptives. Allopurinol , Diuretics, NSAIDs, phenylbutazone   increase in the blood level of ampicillin. When receiving allopurinol may develop a skin rash.