A Lorinden

Description overdue on 07/09/2014

• Latin name: Lorinden A
• ATC code: D07XB01
• Active substance: Salicylic acid + flumethasone (Salicylic acid + Flumetasone)
• Manufacturer: Jelfa S.A., Poland "VALEANT" LLC, Russia

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications for use of the drug
• Contraindications
• Side effects
• Ointment Lorinden A, instructions for use (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• With alcohol
• Reviews
• Price, where to buy

Composition

Lorinden A contains active ingredients:   flumethasone pivalate   and   salicylic acid As well as additional components: white petrolatum, anhydrous lanolin and propylene glycol .

Product form

Produced Lorinden A as ointments packed in tubes of 15 g

Pharmacological action

Ointment has antipruritic, antiallergic, vasoconstrictor, anti-   and anti-inflammatory   action.

Pharmacodynamics and pharmacokinetics

Lorinden A is a combination drug intended for outdoor use, having anti-inflammatory, keratolytic   and other effects due to its composition. One of its active substance - flumethasone pivalate It refers to synthetic corticosteroids. It is characterized by anti, anti, anti- and   antipruritic   effects. This inhibits the activity of phospholipase A2, inhibits the synthesis of prostaglandins and leukotrienes, inhibits the release of inflammatory mediators. In addition, the effect of the drug reduces the migration of leukocytes and lymphocytes in the inflammation. It is also noted to prevent accumulation of neutrophils boundary, reduces the inflammatory exudation and production of cytokines, inhibiting the migration of macrophages that reduce infiltration and granulation. Flumethasone pivalate   significantly reduces the proteolytic activity of kinins tissues, inhibits growth of fibroblasts inhibits the growth of connective tissue at the site of inflammation. Reduced hyperemia, hypersensitivity reactions, exudative and proliferative processes which occur in the connective tissues in the inflammation. The other active component - salicylic acid   NSAIDs is promoting penetration of GCS, supplementing drug antiparakeratoznym, moderate keratolytic and local hypothermic effect. Furthermore, salicylic acid   improves skin penetration Flumethasone . It is also seen Antibacterial   and fungicidal   action set restoration of protective functions of the skin. At the same time inhibits the secretion of the sebaceous or sweat glands, loosened horny epithelium, helps to remove scales. Clinical practice has shown that the absorption flumethasone pivalate   It occurs in children more than adults patients. Particularly susceptible to the skin - on the face, skin folds, the damaged surface occlusive dressings. For this preparation tend rapid distribution after penetrating into the body. The fact that it is ensured salicylic acid , Accelerates and facilitates the absorption of   flumethasone pivalate . Metabolism   preparation takes place mainly in the liver. Withdrawal is carried out mainly in the composition of urine and a bit of the bile in the form of compounds, supplemented glucuronic acid And unchanging substances.

Indications for use of the drug

A Lorinden Ointment is indicated for:

• eczema   - Sub-acute or chronic;
• diffuse neurodermatitis;
• atopic dermatitis;
• hyperkeratosis;
• psoriasis
• chronic dyshydrosis;
• lichen planus;
• seborrhea;
• photodermatitis;
• pruritus with lichenification;
• cystic skin diseases;
• red blisters zoster;
• discoid lupus erythematosus;
• erythema multiforme;
• insect bites.

Contraindications

It is not recommended to use the drug to patients with:

• bacterial, fungal and   Viral   skin lesions;
• tuberculosis of the skin;
• exudative stages of skin diseases;
• syphilis with skin manifestations;
• precancerous conditions and skin lesions;
• acne.

In addition, the use of ointments should be avoided in early pregnancy, trophic ulcers of varicose disease, in case of hypersensitivity in children. Compliance requires careful treatment of patients with a diagnosis - kidney failure, as the danger of significant doses of action nefrotokischeskogo   salicylates.

Side effects

Treatment Lorindenom A may be accompanied by: burning, dry skin   and pruritus . Prolonged use often causes the development of: purpura, skin atrophy, pigmentation disorders, telangiectasia, perioral dermatitis, a local hirsutism and steroid acne.

Ointment Lorinden A, instructions for use (method and dosage)

This external agent is recommended to be applied on the affected surface is sufficiently thin layer every day 2-3 . When the acute inflammation is removed, it is possible to reduce the use of 1-2 times . The disappearance of the painful symptoms not the cause of drug withdrawal, since treatment must continue for at least 3-4 days .

Chronic skin lesions require a stable treatment for 3 weeks. In addition, it permitted the use of occlusive dressings, which are changed after 1-2 days. It is possible to adjust the degree of humidification is particularly dry areas of the layer thickness by means of external means, depending on the therapeutic requirements established for a particular application.

Overdose

Cases of overdose occur infrequently. This can occur during the use of funds for large areas of the skin that causes systemic effects of GCS or poisoning salicylates.

Cooperation

Application Lorinden And during   Vaccination   or   Immunization can strengthen its immunosuppressive effect. Also, do not mix it with other means of external agents. Systemic absorption of the drug GCS is able to significantly reduce the impact of   insulin , Antihypertensive agents, oral hypoglycemic agents and anticoagulants, to reduce the concentration of praziquantel in the blood. Concomitant use Lorinden And with some drugs increase the risk of adverse events, such as androgens, estrogens, oral contraceptives, anabolic steroids, antipsychotics, bukarbanom, azathioprine, holinoblokatorami, antihistamines, tricyclic antidepressants, nitrates, diuretics and some others.

Terms of sale

This external preparation prescription.

Storage conditions

For outdoor storage facilities require a cool, dark and inaccessible to children.

Shelf life

3 years.

Analogs

By analogues of this drug include: Flumethasone pivalate, Lorinden, Lorinden C.   Also, have a similar effect:   Dexamethasone, prednisolone, Diprospan, Methylprednisolone   and others.

Alcohol

Drinking alcohol does not have much effect on the action Lorinden A.

Reviews Lorinden A

Despite the fact that the ointment Lorinden A is a hormonal drug that can be administered by a specialist, many patients use it themselves. This opinion about this outdoor facility has developed a very variegated . Some people tool helps to get rid of skin lesions and improve the quality of life. However, others have reported that the effect is only temporary and does not occur at all.

You can also find messages when patients refuse to use the tool, even if it has appointed a dermatologist. The reason for this lies in the fact that the drug is hormonal . In fact, if the treatment is assigned a specialist after the necessary investigations, it can be safely used external means. In cases where a doctor's appointment in doubt, you can always turn to other professionals who can prove or disprove the initial diagnosis and treatment scheme.

Price Lorinden And where to buy

The external agent Lorinden A can buy almost any Russian pharmacy. The price varies ointment 223-300 rubles.

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