Description overdue on 02/09/2014
- Latin name: Vasonit
- ATC code: C04AD03
- Active substance: Pentoxifylline (Pentoxifylline)
- Manufacturer: Lannacher Heilmittel (Austria)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Vazonita
- Contraindications
- Side effects
- Vases - Instructions for use
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- Synonyms
- With alcohol
- Reviews
- Price, where to buy
Composition
As part of one tablet Pot of 600 mg It contains 600 mg of active substance ( Pentoxifylline ) And adjuvants: Valium 15,000 cP . microcrystalline cellulose . crospovidone . colloidal silica . magnesium stearate .
The structure includes a shell : 6000 macrogol, talc, titanium dioxide, hypromellose 5 cP, polyacrylic acid as a 30% dispersion.
Product form
Medicament prolonged action, film-coated, oblong, white, bi-convex, scored on both sides - 2 blisters of 10 pieces. in a cardboard box.
Pharmacological action
Pot has the following pharmacological effects:
- improves microcirculation blood circulation disorders in the field by improving rheological properties of the blood (flowability);
- It protects the blood vessels from harmful influences ( angioprotective action);
- It relaxes the smooth muscles of the walls of blood vessels (vasodilator effect);
- It inhibits the blood's ability to thrombosis ( antiagregatine action);
- improves the supply of oxygen to tissues.
Pharmacodynamics and pharmacokinetics
The active substance Vazonita - Pentoxifylline It improves blood flow in small blood vessels in the areas where the blood supply is broken. This happens by improving blood flow and expansion of some small blood vessels.
The fluidity of the blood increased by restoring the normal form erythrocyte and Platelet and the suppression of their Aggregation (bonding or adhesion with the subsequent formation of a thrombus). Under the action Vazonita blood level decreases squirrel fibrinogen Which is also involved in the formation of blood clots and amplified fibrinolysis - The dissolution of blood clots. The small blood vessels to dilate more interested tissues improves blood circulation.
Besides that, Flowerpots It improves the oxygen supply - all this contributes to the improvement of cell metabolism and restore the normal life of organs and tissues.
When reducing the patency of the peripheral arteries arise, for example, against atherosclerosis , Improved circulation in the affected limbs leads to that it becomes easier for the patient to walk, reduced or disappear altogether convulsions calf muscles.
Upon receiving Vazonita into its active ingredient gradually and almost completely absorbed in the gastrointestinal tract, providing long lasting effect of the preparation. After absorption pentoxifylline decomposed in the liver with the formation of pharmacologically active metabolites. Maximum concentration in blood reached after 3 - 4 hours, the therapeutic effect lasts for 12 hours.
Pot is displayed in the urine as metabolites. Part of the drug can be released with the feces, and breast milk.
In severe renal dysfunction metabolic products pentoxifylline excreted more slowly, which requires a reduction in drug dosage. If abnormal liver function pentoxifylline increased bioavailability of the drug, which also requires a revision of the dosage.
Indications Vazonita
Vases appoint the following diseases and conditions:
- any violations of blood circulation, including those associated with inflammation of the walls of blood vessels, atherosclerosis, diabetes As well as violation of innervation of peripheral vascular disease ( Raynaud's disease ); on the background and frostbite gangrene;
- circulatory disorders in the brain, associated with changes in vascular permeability and insufficient supply of oxygen to the brain;
- as part of an integrated treatment of the consequences of ischemic stroke associated with impaired intelligence and attention span;
- metabolic and degenerative disorders of the brain by the ( encephalopathies );
- violations of venous circulation in the background Varicose Veins . thrombophlebitis and related trophic ulcers ;
- when visual and hearing impairment associated with disorders of blood circulation in these areas.
Contraindications for use Vazonita
Pot is contraindicated in:
- at myocardial infarction in the acute stage;
- hemorrhage in the brain ( hemorrhagic stroke );
- when visual impairment associated with hemorrhage;
- when any significant bleeding;
- during pregnancy and breastfeeding Child;
- children and adolescents under the age of 18 years (clinical trials were not conducted);
- at are hypersensitive Vazonita components.
Caution is needed in the appointment of Vazonita atherosclerosis blood vessels of the brain and the heart, low blood pressure, heart rhythm disturbances, disturbances of function of the circulatory system, liver and kidney failure, ulcerative lesions of the gastrointestinal tract in the postoperative period and increased bleeding (eg, menstrual and intermenstrual uterine bleeding), and in the elderly age.
Patients with impaired renal and hepatic function, as well as elderly patients and have low blood pressure, this drug should be administered in individually selected lower than the recommended dosage.
The drug Pot - side effects
Pot has a lot of side effects from the other organs and systems.
On the side CNS - A strong giddiness, up to fainting, headache, drowsiness, or insomnia , Convulsive readiness; encountered isolated cases of meningitis . Dizziness may create an obstacle in driving mode, and thus during treatment you should not get behind the wheel.
On the side circulatory system - Increased heart rate, heart rhythm disorders, heart pain (including in the form of attacks angina ), Decrease in blood pressure (sometimes sudden and significant).
From the side view, - Violation of visual acuity, loss of peripheral vision fields.
On the side gastrointestinal tract - Loss of appetite, dry mouth, nausea, vomiting, diarrhea, alternating with constipation Severity and pain in the stomach.
On the side liver and biliary tract - Pain in the right hypochondrium, transient abnormal liver function, exacerbation of chronic inflammation of the bile ducts and gall bladder (chronic cholangitis and cholecystitis ).
Blood system - Increased bleeding, bleeding of internal organs, gums, nasal bleeding, reduction in the blood levels of all cell elements, primarily Platelet and leukocytes . Perhaps the development of anemia .
On the part of the skin and its appendages - Rush of blood to the upper body and face, swelling, brittle nail plate.
The medicine can cause allergy Which is manifested in the form of hives . angioedema , Skin rash and itching. Perhaps the development of a severe allergic reaction in the form anaphylactic shock .
Vases - Instructions for use
Flowerpots It is recommended to take a tablet of 600 mg twice a day after meals, not chewing and drinking water.
Individual patient dose of the drug, as the duration of the pills the doctor individually selected.
For example, instructions for use Vazonita for treatment of patients with impaired liver and kidney function, low blood pressure in the elderly recommends reduction in unit dosage.
Overdose Vazonita
Overdose Vazonita is possible. It manifests itself in a sharp lowering blood pressure , Accompanied by nausea . heartbeat . shortness of breath . weakness , Feeling shortness of breath . redness of the face and the upper body, chills . Sometimes such a state comes to an end loss of consciousness and convulsions . If the patient has ulcerative lesions gastrointestinal tract or sores may bleed.
If overdose is suspected, it is better to call an ambulance. Prior to her arrival, the stomach should be washed and have a few pills Activated Carbon .
Vazonita Interaction with other drugs
The drug interacts with many drug substances, it enhances the effect of:
- medicines that suppress the action of the blood coagulation system - direct and indirect anticoagulants and etc.;
- antibiotics from the groups cephalosporins (eg, ceftriaxone );
- valproic acid - With the anticonvulsant action of the drug;
- drugs that lower blood pressure;
- medicines to treat diabetes.
When taken together with the theophylline recently could overdose.
When taken together with the cimetidine there is a risk of overdose Vazonita.
Terms of sale
Pot available on medical prescription.
Storage conditions
The drug should be stored in a dry place out of reach for the sun and children, at a temperature not exceeding 25 ° C.
Shelf life
The drug is kept for 5 years, subject to the above conditions.
Analogs Vazonita
Ksantinola nicotinate
Trental
Pentoxifylline
Agapurin
Analogs - a variety of dosage formulations groups which are used to treat the same disease. The analogue is Vazonita Ksantinola nicotinate ( Komplamin . Thiokol ) - A drug that has a similar effect, but the active ingredient has a different. It improves the peripheral circulation (including the blood circulation in the brain and the organ of vision) enhances oxygen delivery and uptake by cells of the brain, decreases platelet aggregation .
Synonyms Vazonita
Available as many synonyms Vazonita, ie, drugs, the active ingredient of which is pentoxifylline. It Fleksital . Agapurin, Trental . Latro . Pentoxifylline and etc.
Alcohol and vases
Drinking alcohol during treatment Vazonitom contraindicated. Smoking reduces the therapeutic effect of the drug.
Reviews of Pot
Basically reviews for this drug positive When administered Vazonita in the complex treatment of various diseases in violation of the peripheral circulation of patients with the condition gradually improved. But disease is difficult to treat and require long-term complex treatment under medical supervision.
Negative Reviews Pot 600 mg are mainly associated with side effects and overdose of the drug. That is why the vases must appoint a physician with all the indications and contraindications.
Price Vazonita
Price Vazonita 600 mg in Moscow varies from 275 to 340 rubles.
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