Nalbuphine

Description overdue on 08/12/2014

• Latin name: Nalbuphinum
• ATC code: N02AF02
• Active substance: Nalbuphine (Nalbuphine)
• Manufacturer: Moshimfarmpreparaty of them. Semashko (Russia)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on nalbuphine (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

1 ml of solution for injection (intravenous, intramuscular) contains 20 mg or 10 mg nalbuphine hydrochloride .

Product form

The drug is produced in 10 ml ampoules. 5 or 10 vials per pack.

Pharmacological action

Analgesic .

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The drug is analgesic   opioid type. It stimulates the inner antinociceptive system mainly through kappa opioid receptors . Stops interneuronal transmission of impulses of pain in the nervous system, alters the emotional perception of pain by stimulating the higher parts of the brain.

By analgesic effect comparable to M Orfin Causes corestenoma , Has a stimulating effect on the vomiting center, has a sedative effect, it suppresses the conditioned reflexes. It inhibits the respiratory center is less than m Orfin, fentanyl   or P romedol .

The analgesic effect of rapidly developing and intravenous administration occurs within 1, 5-3 minutes; intramuscular - after 11-15 minutes. The greatest analgesic effect could be observed after 1, 5-2 hours, its length does not exceed 6 hours.

Pharmacokinetics

The metabolism takes place in the liver. The half-life is 3 hours. The original structure excreted in the urine (70%), in the form of derivatives - the bile.

Indications

Strong pain syndrome   (as after surgery, gynecological surgery, in heart attack When tumors); premedication prior to inhalation anesthesia, as a component of intravenous anesthesia.

Contraindications

Allergies   on nalbuphine.

Side effects

• From the circulatory system: arterial Hyper - Or hypotension , Decrease in heart rate or palpitations.
• From the nervous system: dizziness , Drowsiness, headache . depression . dysphoria , Blurred vision.
• From the digestive system: nausea, vomiting.
• Allergic reactions: hives .
• Other: increased sweating.

Instructions on nalbuphine (method and dosage)

Instructions for use Nalbuphine characterize the dosing regimen, as an individual. The drug is administered intravenously, intramuscularly and subcutaneously. From 100 mg per kilogram body weight to 1 mg per kilogram of body weight single dose ranges for adults. For children primary single dose - 300 micrograms per kilogram of body weight. Multiplicity of administration depends on the clinical picture. Duration of treatment - up to 3 days.

Overdose

There are no reports of such cases.

Cooperation

When used together with drugs for anesthesia, sedatives   preparations hypnotics . antidepressants, tranquilizers, antipsychotics, antihistamines   means ethanol a depressing effect on the nervous system is enhanced.

Terms of sale

The drug is a list of prescription. The free circulation of the drug was banned.

Storage conditions

Store in a dark place at a temperature of 15 to 30 degrees. Keep away from children.

Shelf life

Two years.

Cautions

As preservative agent contains sodium bisulfite Which may provoke patients with asthma   (from Allergies   for sulfite) attacks and anaphylactic shock .

Analogs Nalbuphine

Analogues: Nalbuphine Serb . Nalbuphine hydrochloride.

Babies

Can be used in children under strict indications.

With alcohol

Alcohol aggravates the negative effects of drugs.

During pregnancy (and lactation)

During pregnancy   or Lactation drug ampoules may be used only on strict conditions.

Reviews of nalbuphine

Reviews of nalbuphine occur as sharply positive or negative. However, on the severity of pain, the tool helps not always effective. And the consequences of uncontrolled dosing can be disastrous, for example, the development of dependence. Therefore, one can often find discussions on "how to throw nalbuphine? "Or" nalbuphine, ready or not rushing as morphine? ".

Price Nalbuphine where to buy

Buy nalbuphine №10 in Moscow will cost 880-1130 rubles, for comparison, the same price Nalbuphine release forms in Kiev will cost an average of 326 hryvnia.

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