Description overdue on 09/25/2014
- Latin name: Fusys
- ATC code: J02AC01
- Active substance: Fluconazole (Fuconazole)
- Manufacturer: Kusum Helthker.ltd., India
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Futsis (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
Tablets Futsis contain the active substance - Fluconazole in varying dosage, and also auxiliary components.
AT tablets Futsis DT It contains 50 mg Fluconazole and auxiliaries.
Part solution for infusion administration 100 ml encompasses: Fluconazole - 200 mg and additional components.
As auxiliaries used: microcrystalline cellulose, lactose, povidone K30, magnesium stearate, talc, sodium starch glycolate, croscarmellose sodium and so on.
Gel Futsis It includes in its membership Fluconazole - 5 mg Excipients : Carbomer, benzyl alcohol, octyldodecanol, polysorbate 80, propylene glycol, sodium hydroxide, flavor Delite and purified water.
Product form
The drug is available in the form of tablets with a dosage of 50, 100, 150 and 200 mg of active substance to 4 pcs. in a blister, packed in a cardboard box. Futsis Tablets 150 mg - 1 piece. in a blister pack, placed in a cardboard box. Tablets dispersed with 50 mg acting component on 4 pcs. in a blister, packed in a cardboard box.
A solution for intravenous administration in bottles of 100 ml, one bottle in a cardboard box.
A preparation in form of gel is invited in a tuba to 30 g, packaged in cardboard wad.
Pharmacological action
Each form of the drug has antifungal effect broad spectrum of activity.
Pharmacodynamics and pharmacokinetics
Fluconazole, the active ingredient of the drug is a synthetic derivative of the group thiazole compounds. The effect of this material eliminates the enzymatic activity of specific compounds in the cells of fungi. As a result of sterol biosynthesis of damaged joints in fungal cells, inhibits the conversion of lanosterol at ergosterol . Changes in the cell membrane causes the cessation of reproduction of fungi due to violations of replication. The effectiveness Futsisa directed to strains such as: Coccidioides immitis, Cryptococcus neoformans, Trichophytum spp. and Microsporum spp., Hystoplasma capsulatum, Blastomyces dermatitidis, and so on.
For the Fluconazole is characteristic low toxicity, therefore the drug is not exerts the negative impact of on an organism and significant impact on the cytochromes human and abundance of androgenic hormones in the composition of of blood plasma.
Tablets intended for indoor reception, well absorbed in the gastrointestinal tract. Fluconazole has high bioavailability, the use of food has no effect on the absorption process. Maximum concentration in blood plasma has detected after 30-90 minutes from the time of reception.
It exhibits good penetration into the substance of biological fluids and tissues. Furthermore, Fluconazole penetrates c / o blood brain barrier, cerebrospinal fluid concentrating to 80% of plasma concentrations. Excretion Fluconazole is carried in the urine - a part intact, the rest - metabolites . The half-life is 30 hours.
Farmokinentika intravenous administration Fluconazole is virtually identical to the received orally.
Antifungal agent as gel It possesses such same activity and the characteristics of, as the and other forms of Futsisa. Especially effective it affects dermatophytes and yeast .
During outdoor use only a small amount substance adjudged into the plasma blood, therefore its systemic action you can exclude. It is also found that the gel does not have a negative impact on the skin.
Indications
The main indications for the use of a Futsisa the need for treatment of infectious diseases of different localization Caused by microorganisms are sensitive to fluconazole.
Pills prescribed for:
- Candida infections different localization - candidemia, candiduria, disseminated candidiasis, other forms generalized candidiasis Caused by the fungus Candida;
- infections of the mucous membranes Which cause fungi Candida;
- bronchopulmonary non-invasive candidiasis infections ;
- chronic candidiasis the oral cavity, associated with wearing of removable dentures;
- the treatment of acute and chronic recurrent vaginal candidiasis;
- therapy sporotrichosis, histoplasmosis and area points of of endemic of mycoses ;
- treatment d ermatomikozov, mycosis in the groin and on the feet, onychomycosis and pityriasis depriving .
Also, pills may be appointed for the relapse prevention in patients with:
- chronic vaginal candidiasis;
- candidal balanitis;
- cryptococcal infection various localization and so on;
- g ribkovymi infections of various localization, if patients suffer immunodeficient or are receiving cytostatic and radiation therapy.
The solution for infusion administration prescribed for the treatment of:
- systemic fungal infections, for example: candidemia, candiduria, Candida infections of the eyes, endocardial ;
- cryptococcal meningitis;
- cryptococcal infections the skin surface and respiratory organs.
Gel used for the treatment:
- dermatomycoses That cause yeast;
- dermatophytes - Athlete's foot, jock itch, trihofitii, kandidnyh infections, multi-colored lichen.
Contraindications
Not recommended for use when Futsis:
- individual Sensitivity its components and other azole compounds, whose structure is close to fluconazole;
- lactation, pregnancy;
- the age of 7 years.
This indicates that Futsis DT can be used for children from 3 years.
Side effects
Application Futsisa can cause a number of side effects affecting the work:
- Nervous System - Headache, dizziness, tremors, convulsions;
- cardiovascular system - Arrhythmia, tachycardia ;
- the liver and gastrointestinal tract - Nausea, vomiting, pain, digestive disorders, diarrhea and so on.
Also, undesirable manifestations on the skin and allergic reactions : alopecia, toxic epidermal necrosis . itching, skin rash, hives, swelling, Stevens-Johnson syndrome .
In addition, the use of Fluconazole It may affect the laboratory results : Leukopenia, neutropenia, agranulocytosis, thrombocytopenia, hypokalemia, the level of cholesterol and triglycerides in the composition of blood.
The manifestation of the side effects require discontinuation of Futsisa.
Instructions on the Futsis (Method and dosage)
The preparation tablets the content of 50-200 mg Fluconazole is used in the treatment of adults and children of 7 years. Accepts them orally in the any time. The daily dosage of the drug is established at one go.
Tablets Futsis DT User is recommended to dissolve in water. Also allowed Futsis DT for children from 3 years. Typically, the drug is used at 50mg 5ml water.
AT R astvore infusion It contains 200 mg of fluconazole with 100 ml of isotonic sodium chloride solution. When the infusion solution is administered to patients who should limit the introduction of fluid and sodium need to consider the content of sodium and chlorine in the solution is 15 mM. The drug is not recommended to mix with any solution for infusion, despite the absence of a pronounced pharmacological incompatibility.
Gel Futsis instructions for use recommends using every day. This means gently rubbed into the affected areas of skin around them.
It should apply a very small amount of gel and triturated it across the surface to prevent maceration.
The dosage and duration of treatment of each form of the drug is determined by the attending physician. For example, patients suffering from genital candidiasis appointed single 150 mg fluconazole tablets. To prevent a recurrence of chronic vaginal candidiasis - from yeast appointed 150 mg of the drug per month. This takes into account the nature of the disease and the individual characteristics of the patient. The dosage of the drug is independent of the use and is usually not changed in case of transition from the parenteral to oral administration.
Overdose
In cases of overdose of tablets or solution Futsis may develop negative symptoms such as: headache . dizziness or hallucinations . Also, do not exclude the occurrence of paranoid behavior of patients.
In such cases, carry out gastric lavage and other symptomatic therapy. Allowed the use of forced diuresis and hemodialysis.
No cases of overdose caused by the use of the drug in gel form, are not reported.
Cooperation
The simultaneous use of tablets or solution Futsis with anticoagulants can significantly enhance their effect. Therefore, you must perform regular monitoring of indicators of the prothrombin time.
This may increase the plasma drug concentration midazolam, benzodiazepine, cyclosporine, rifabutin and phenytoin in the blood. In the combined treatment flucanozole and any of the funds required strict control of dosing and monitoring specialist. Failure to comply with of these rules can cause the development of psychomotor reactions, to strengthen side effects associated with the work of the cardiovascular system and so on.
If you regularly use hydrochlorothiazide with Futsisom, we can expect a significant increase in plasma concentrations of fluconazole, but it does not require dose adjustment.
Admission does not reduce the effect of Fluconazole combined oral contraceptives .
During the treatment of patients with Futsisom diabetes We must take into account the likelihood of hypoglycemia. Simultaneous use with rifampicin It requires increasing doses of Fluconazole. The combination of fluconazole tacrolimus often causes mutual enhancement of nephrotoxicity. When the drug is taken with theophylline Then there is likely to overdose theophylline Because it will reduce the clearance Fluconazole theophylline from the blood plasma.
With regard to the gel Futsis, then of data about his drug interactions with other medications not reported. It is recommended to abstain from simultaneous application of any external means.
Terms of sale
The drug prescription.
Storage conditions
For storage Futsisa requires a cool, dry place, protected from light and children.
Shelf life
3 years.
Analogs
Flucostat
Diflyuzol
Rumikoz
Vero Fluconazole
Kandizol
Kanditral
Itraconazole
Mikosist
Diflazon
Itrazol
Diflucan
Orungal
Mikomaks
Fluconazole
Irunine
For drugs with similar action are: Fluconazole, clotrimazole, Fukortsin and Livarol.
Alcohol
In the treatment of any form of the drug alcohol is highly undesirable Since it can not only reduce a therapeutic effect, but lead to side effects.
Reviews Futsise
This drug is widely applied in the treatment of thrush . However, many users report that Futsis helps get rid of the disease for many years. Of course, should not be forget about the additional therapy, helps to restore normal microflora of vaginal environment.
However, by using a tablet Futsis thrush Some patients reported the development of side effects . This is usually manifested swelling, itching of the mucous membranes of the nose and eyes, headache, and fever.
Another problem is the independent use of the drug. Not attending physician, patients buy these pills, and then interest on the forums, how to take thrush that the treatment was effective.
Pro gel Futsis reviews patients are less common, but almost all of them positive . This is particularly useful in the treatment agent dermatomycoses . However, despite the high efficiency of of the given preparation, prior to the beginning of treatment need to address to the doctor to select the optimal dosage and schemes of treatment.
Price Futsisa where to buy
Price Futsis 150mg in Ukraine is about 42 UAH. Thus the price tablets in such cities, as the Donetsk or Harkov varies within the limits 40-52 UAH., Gel - 60-65 UAH.
In the online pharmacies in Moscow Futsis 150 mg can be ordered at the price of 349 rubles.
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