Description overdue on 10/26/2014
- Latin name: Solcoseryl
- ATC code: B05Z A (injection) S01X F23 ** (ocular gel) D03A X50 ** (cream and jelly)
- Active substance: The purified protein extract from the blood of healthy dairy calves
- Manufacturer: MEDA Pharmaceuticals Switzerland GmbH, Valeant Pharmaceuticals Switzerland GmbH, SOLCO, ICN, Switzerland; Valeant Pharmaceuticals Germany GmbH, Germany
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Solcoseryl
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
Part solution 42 includes injection, 5 mg / ml gemoderivat (extract) from bovine blood as the active agent and water for injection (Aqua pro injectionibus) as an auxiliary component.
One gram eye gel 8 contained 3 g of active substance and auxiliary ingredients: sodium carboxymethylcellulose (Sodium carboxymethyl cellulose), sorbitol (Sorbitol), water for injection (Aqua pro injectionibus), benzalkonium chloride (Benzalkonii chloridum).
One gram ointment Solkoseril contains 2, 07 mg of active substance and several auxiliary components: methyl parahydroxybenzoate (E 218; Methyl parahydroxybenzoate), propyl parahydroxybenzoate (E 216; Propyl parahydroxybenzoate), cetyl alcohol (Cetyl spiritus), cholesterol (Cholesterol), white petrolatum (Vaselinum album), water for injection (Aqua pro injectionibus).
One gram jelly Solkoseril contains 4 to 15 mg of active substance and several auxiliary components: methyl parahydroxybenzoate (E 218; Methyl parahydroxybenzoate), propyl parahydroxybenzoate (E 216; Propyl parahydroxybenzoate), Propylene Glycol (Propylene glycol), carboxymethylcellulose sodium salt (Sodium carboxymethyl cellulose), water for injection ( Aqua pro injectionibus), calcium lactate pentahydrate (Calcii lactas pentahydrate).
Product form
The drug has several dosage forms:
- solution for injection;
- ointment;
- eye gel;
- jelly;
- dragees.
The solution was discharged into dark glass ampoules of 2, 5 and 10 ml of ointment and jelly - in tubes with capacity of 20 g, eye gel Solcoseril - in tubes with capacity of 5 Bean 0 04 g, 0, 0 and 1 g, 2 g in a package of 20 pieces.
Pharmacological action
Solkoseril - it's drugs, affecting mainly on metabolism in tissues. They activate processes of tissue metabolism , Improve trophism and stimulate repair and tissue regeneration in the case of exposure to damaging factors.
Solkoseril in injectable form refers to the pharmacotherapeutic group " Gemodializaty and gemofiltraty "Ointment and jelly - the category of drugs used for the treatment of wounds and ulcers (including poorly healing) the gel - the category of drugs used to treat ophthalmic diseases .
Pharmacodynamics and pharmacokinetics
The main components of the drug Solkoseril - it blood fractions calves with their member natural low molecular weight substances, the molecular weight of not more than 5 thousand. Dalton.
To date, its properties were studied only in part. Tests conducted in vitro, as well as pre-clinical and clinical studies have shown that an extract of calf blood:
- contributes to the restoration and / or maintenance aerobic metabolism and processes of oxidative phosphorylation and provides replenishment of cells do not get enough food, high-energy phosphates;
- in vitro enhances oxygen utilization and activates glucose transport to suffer from hypoxia and metabolically depleted tissues and cells ;
- improves reparation and regeneration processes in damaged tissues do not get enough food;
- prevents or reduces the severity of the development degradation and secondary lesions a reversibly injured cells and cell systems ;
- models in vitro activates the synthesis of collagen ;
- stimulates the proliferation (growth) of cells and their migration (on models in vitro).
Thus, Solkoseril protects tissues in a state of oxygen deficiency and malnutrition accelerates the process of recovery and healing.
Solkoseril eye gel is a formulation that was developed specifically for the treatment of injuries from Troma cornea .
The gel consistency means it provides uniform distribution on cornea And good adhesion properties allow it to remain there for a prolonged period of time. The use of eye gel accelerates regeneration of damaged tissue and prevents them from scarring.
The rate and extent of absorption, distribution, as well as speed and road clearance of the active substance from a patient can not be defined using conventional pharmacokinetic methods because protein-free calf blood extract It has pharmacodynamic effects which are characteristic of molecules with different chemical and physical properties.
In the course of studying the pharmacokinetic parameters of the solution Solcoseril animal was found that after bolus injection of drug action is developed within half an hour. This effect persists for three hours after administration of the solution.
Indications
Injections Solcoseryl: what they are and how they are assigned groups of patients?
Solkoseril in capsules is indicated for patients who have been diagnosed peripheral arterial occlusive disease third or fourth level of classification Fontaine and who have contraindications or intolerance to other vasoactive drugs .
Also, it is prescribed in patients with chronic venous insufficiency Which is accompanied by the formation of stable therapy trophic ulcers And in patients with impaired cerebral metabolism .
From what ointment and gel Solkoseril?
Application of ointments and jellies suitable for treatment minor injuries (e.g., cuts or abrasions) frostbite, burns I and II degree (thermal or solar) hardhealed wounds (eg, trophic disorders of the skin venous etiology or bedsores ).
Indications for use of the gel for eyes
Eye Gel Solkoseril recommended:
- for the treatment of injuries and mechanical erosive damage to the cornea and conjunctiva ;
- to speed up the healing process scars in the postoperative period (for example, after corneal transplantation , Surgery to remove cloudy lens . Surgical treatment of glaucoma etc.);
- treatment burns, corneal origin of various nature (thermal, chemical or radiation);
- treatment ulcers of the cornea and keratitis of various etiology ;
- at dystrophic lesions of the cornea various etiologies, including but not limited neuroparalytic keratitis . endothelial-epithelial dystrophy ( bullous keratopathy ) etc.;
- treatment Corneal xerophthalmia when lagofatalme (nesmykanii eye slits);
- to improve the tolerability of contact lenses and reduce the time to adapt.
Indications pills Solkoseril
The drug is in the form of pills taken to treat trophic ulcers and radiation . bedsores . gangrene . chronic venous insufficiency . They are also prescribed to patients with stomach ulcer and 12 tiperstnoj intestines and patients who need to conduct procedures skin grafting and / or cornea .
Contraindications
Introduction of the solution is contraindicated in patients with a determined hypersensitivity to dialysate calf blood. Also, the solution is contraindicated in atopy and persons with allergic to milk .
As the ointment, jelly, solution contain in their composition the derivatives parahydroxybenzoic acid They used as a preservative as well as trace concentrations benzoic acid in free form, it is not used in the presence of allergic reactions to the above substances.
With care cream and jelly appoint persons who have a predisposition to allergic reactions .
Contraindication to eye gel is a hypersensitivity to its components. Since the eye gel can cause temporary visual impairment, within half an hour after its application should not get behind the wheel of a car and operate potentially dangerous machinery.
Side effects
Introduction Solcoseryl in / in or / m in very rare cases (their frequency is less than 0, 1%) provokes allergic or anaphylactic reactions Which likely are due immunoglobulin E .
An increase in body temperature, appearance hives . edema and hyperemia at the site of drug application Solcoseryl stop, and to eliminate the symptoms manifested appoint symptomatic treatment.
Because the solution contains potassium, its introduction can cause soreness at the injection site.
When applying the cream Solkoseril in the place of its application may feel a brief burning sensation. Removal of the drug is required only in those cases where an unpleasant feeling persists for a long period of time.
In rare cases the use of gel and ointment may cause the development of allergic reactions . When allergy symptoms the use of these funds should be abandoned.
Toxicological studies Solkoseril eye gel showed high safety of the drug when it is used as intended in accordance with the instructions.
After instillation of funds may experience short-term burning and slight irritation, which are not a cause for discontinuation of treatment. Repeated instillation in rare cases provoke the development of a llergicheskih reactions (a similar effect is also observed in the treatment of other ophthalmic preparations for topical use).
Instructions for use Solcoseryl
Injection: instructions for use
In those cases where it allows the patient, the drug is recommended as a solution for injection at a dilution of at least 50:50 with saline or glucose solution .
Solcoseril ampoules for administration as a slow I / injection or infusion. If intravenous administration is impossible, it may be to introduce the drug into the muscle.
Because the drug in its pure form is a hypertonic solution, it should be administered slowly.
For in / infusion should be pre-diluted with 0, 25 l 0.9% NaCl solution or 5% glucose solution . Solkoseril administered intravenous solution droplets. The rate of administration depends on the hemodynamic status of the patient.
Patients with peripheral arterial occlusive disease third or fourth level of classification Fontaine shows the daily administration of the vein 0, 85 g (20 mL or undiluted solution) Solcoseryl.
The duration of typically up to four weeks, depending on the clinical situation.
Patients with chronic venous insufficiency Which is accompanied by the formation of stable therapy trophic ulcers Shown 0 intravenous administration, 425 g (or 10 ml of the undiluted solution) Solcoseryl three times a week.
The duration of treatment should not exceed four weeks (it is determined depending on the nature of the disease).
To prevent the emergence of peripheral "venous" edema , Complementary therapy overlaying pressure bandage using an elastic bandage. If a patient trophic skin disorders treatment is carried out by combining injections or infusion solution Solcoseril with jelly and then ointment.
Patients undergoing ischemic or hemorrhagic stroke in severe or very severe, as the main course of prescribed daily administration vein 0, 425, or 0 to 85 g Solcoseryl (10 or 20 ml of the undiluted solution). The duration of the basic course - 10 days.
Further treatment involves daily administration of 85 mg (or 2 ml of undiluted solution) Solcoseryl within one month.
In severe forms brain contusion assigned daily administration vein Solcoseryl 1000 mg (corresponding to 23-24 ml of undiluted solution) for 5 days.
Preparation is administered intramuscularly in undiluted form at a dose of 2 ml / day ..
Jelly and cream Solkoseril: instructions for use
The cream and ointment designed for application directly to the wound surface. Before using these prior formulations wound purified using the disinfectant solution.
Patients with trophic ulcers And in the case purulent wound infections Before starting treatment requires pre-surgical treatment.
Using gel and ointment, frostbite As well as for the treatment of ulcers and skin injuries It is important to remember that for the treatment of damaged areas, use only sterile dressing.
Gel for application on fresh (including wet) wounds and oozing sores . Means are thin pre-treated wound surface two or three times per day.
For processing sites with epithelialization outbreak shows the use of an ointment. Application jelly advisable as long as the damaged surface of the skin begins to form granulation tissue and expressed the wound has started to dry.
The ointment is used primarily for the treatment of dry (without the phenomena soak) wounds . Means to apply a thin layer of pre-treated wound surface once or twice a day. If necessary, the treated surface is covered with a bandage.
The course of treatment in the dosage form continues until the wound is healed, and time to heal completely elastic fabric.
Patients with severe skin lesions trophic and soft tissues should be combined and jelly ointment Solcoseryl injectable form.
Experience with jelly and cream for children is limited.
There is no such drug release forms like candles. Nevertheless, in the treatment of chronic colitis (inflammation of the colon) are often prescribed microclysters jelly Solkoseril.
Before use, contained in a tube of jelly (all 20 g) was added to 30 ml of warm water, and after the procedure klizmirovaniya being done to clean bowel Administered daily for 10 days.
Eye Gel Solkoseril: instructions for use
If the doctor does not request otherwise, buried in the eye gel conjunctival cavity one drop three or four times per day. Apply agent recommended daily until complete healing.
In particularly difficult cases, the ophthalmic ointment is permitted to apply a drop per hour. If a patient simultaneously appointed eye drops and eye gel Solkoseril, the gel should be applied about half an hour after the drops.
During the adaptation to contact lenses buried in the preparation conjunctival cavity just before the how to install lenses and immediately after their withdrawal.
Drops Solkoseril: instructions for use
Tablets guide recommends taking 100 mg three times a day.
Overdose
Cases of overdose solkoserilom not registered.
Cooperation
Eye gel is allowed to use in combination with the most used agents in ophthalmology.
The solution should be used with caution with drugs that increase the levels of potassium in the blood.
Solkoseril ampoules is incompatible with the intended parenteral drug Ginkgo biloba, Naftidrofuryl (Naftidrofurylum) and Bentsiklana fumarate (Bencyclane fumarate).
Terms of sale
The solution released under the prescription, the other dosage forms are classified as non-prescription.
Storage conditions
The drug in all its dosage forms stored at temperatures not exceeding 25 ° C. After opening the tube jelly, ointment, eye gel and suitable for use within 28 days.
Shelf life
60 months.
Cautions
Studies concerning the safety of the solution Solkoseril to treat children have not been conducted, and the drug is not recommended to treat children under the age of 18 years.
The experience of treatment of children with eye gel and topical dosage forms of the drug is also limited.
Solkoseril in ampoules to be administered separately from other medications (especially incompatible he phytoextracts). The exception is isotonic 0, 9% NaCl solution and 5% glucose solution . Also, it is not recommended to plant facility in potassium-containing solutions for infusion.
Eye gels are characterized by their ability to adhere to the contact lens, so at the time of treatment is recommended to stop wearing the lenses.
In the case of allergic reactions Associated with use of the drug, they should be reported immediately to your doctor. If the drug is used to treat infectious diseases of the cornea , Complemented by the administration of appropriate therapy antimicrobials .
It is necessary to avoid contact of the gel with soft contact lenses as it can discolour them.
If necessary, treatment can be supplemented solkoserilom antibacterial . vasodilator and other drugs.
Solkoseril in cosmetology: face, hands, calloused elbows and heels for skin around the eyes
In medicine, drugs Solkoseril used to promote healing of damaged skin, in the home as they are used in cosmetics as a means of acne, stretch marks, wrinkles. They are used to soften the skin, improve its turgor, improve complexion and remove traces of acne .
Ointment in cosmetology can be used as an independent means (it is applied to a dot on the problem areas in a mask once a week at night, and two or three times weekly to the skin around the eyes) and in combination with other agents (in particular, drug- Dimexidum ).
For face Dimexidum
.
. . Bepanten . . . Depantol . . . . . . . .
allergic reactions
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