Description overdue on 06/23/2014
- Latin name: Fevarin
- ATC code: N06AB08
- Active substance: Fluvoxamine (Fluvoxamine)
- Manufacturer: ABBOTT BIOLOGICALS (Netherlands)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Luvox
- Contraindications
- Side effects
- Instructions for use Luvox
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One tablet contains Luvox: fluvoxamine maleate - 100 or 50 mg.
Excipients: corn starch - 80 or 40 mg; mannitol - 303 or 152 mg; pregelatinized starch - 12 mg, or 6; Sodium stearyl fumarate - 3, 5, or 1, 8 mg; colloidal silica - 1, 5 or 0, 8 mg.
The composition of the shell: Macrogol 6000 - 2, or 1, 5 mg; Valium - 5, 6, or 4, 1 mg; talc - 0, 4, or 0, 3 mg; titanium dioxide - 2, 1 or 1, 5 mg.
The preparation is not lactose and sugar .
Product form
Tablet, regardless of dosage are available in blister 15 and 20 pieces, in a cardboard bundle 4, 3, 2 or 1 such blister.
Pharmacological action
The drug has antidepressant action .
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
The drug selectively inhibits the reuptake Serotonin brain cells and have minimal effect on the noradrenergic transmission. It has a weak ability to interact with histaminergic, cholinergic, alpha and beta-adrenergic, dopaminergic m- and serotonergic receptors .
Pharmacokinetics
When taken orally completely absorbed from the intestine. The maximum concentration observed 4-8 hours after administration, the equilibrium concentration reached after two weeks. Bioavailability - 53% after the initial metabolism by the liver. Food does not affect the pharmacodynamics of Luvox.
Approximately 80% of the active substance molecules are bound to blood proteins.
The half-life from the blood of a single dose of 13-15 hours, with multiple dose - 17-22 hours.
Metabolism Luvox localized in the liver. The drug undergoes biotransformation by oxidative demethylation . Metabolites are excreted by the kidneys. Pharmacologically active metabolites have only 2 of 9.
Pharmacokinetics is the same, regardless of age and the presence of renal failure. Metabolism can be inhibited in patients with liver disease.
Indications Luvox
Indications Luvox reduced to the need for prevention and therapy depression Treatment Obsessive-compulsive symptoms.
Contraindications
It is forbidden to assign Luvox at the same time MAO inhibitors, tizanidine or Ramelteon . For drug treatment can begin only after 14 days after discontinuation of irreversible MAO inhibitors And on the following day after discontinuation of the reverse inhibitor MAO .
Therapy MAO inhibitors start 1 week after cancellation Luvox.
The drug is contraindicated in persons with hypersensitivity to fluvoxamine maleate or any other components of the drug with severe liver disease, and children younger than eight years.
Side effects
- From hemopoiesis system: bleeding (gastrointestinal, gynecological, ecchymosis ).
- From endocrine system: the imbalance development antidiuretic hormone . hyperprolactinemia .
- From the Nutrition and Metabolism: anorexia . hyponatremia , Change in body weight.
- On the part of the psyche: hallucinations, delusions, suicidal thoughts and behavior.
- From the nervous system: agitation, anxiety, nervousness, insomnia , Drowsiness, headache, tremor . ataxia . convulsions . serotonin syndrome . paresthesia .
- From the side view: mydriasis . glaucoma .
- Cardio-vascular system: tachycardia . hypotension .
- From the digestive system: constipation , stomach ache, diarrhea , Nausea, dyspepsia , Disruption of the liver.
- Skin: sweating, rash, itching, angioedema , Photosensitivity.
- From the musculoskeletal system: pain in the muscles and joints, fractures.
- With the genitourinary system: a variety of urinary disorders (urinary retention, incontinence, enuresis and other), late ejaculation . g alaktoreya , Anorgasmia, menstrual disorders.
- General disorders: asthenia, general weakness, withdrawal syndrome.
Discontinuation of treatment fluvoxamine often causes the development of the syndrome. Abolition of the drug is recommended gradually.
Instructions for use Luvox
According to the instructions for use Luvox dosing regimen set individually in each case. Initially, the daily dose is 50-100 mg of the drug (one or two tablets per dose dependent). The drug is recommended to take at night. If necessary, the daily dose is increased up to 150-200 mg. The maximum daily dose is 300 mg. If the daily dose is 100 mg, it is necessary to use two or three stages.
Official recommendation of the World Health Organization continue to recommend treatment with drugs from the group Antidepressants even 6 months after the disappearance of symptoms of depression.
Overdose
Symptoms of an overdose.
- From the digestive system: nausea . diarrhea , A violation of liver function.
- From the nervous system: convulsions . drowsiness . coma . dizziness .
- It was also reported about problems with the heart: bradycardia, tachycardia, hypotension .
Fatal cases of overdose fluvoxamine It is extremely rare. The highest fixed dose overdose - 12 grams. The person who took this dose, fully recovered.
Treatment. There is no specific antidote. In case of overdose the stomach should be washed and prescribe symptomatic treatment. Recommended Use Activated Carbon . Hemodialysis or forced diuresis ineffective.
Cooperation
- When co-administered with MAO inhibitors there is a probability of occurrence serotonin syndrome .
- In a joint application with alprazolam, bromazepam, diazepam the concentration of these medications in the blood increases, and increases their negative effects.
- Together with the admission amitriptyline, clomipramine, imipramine, maprotiline, carbamazepine, trimipramine, clozapine, olanzapine, propranolol, theophylline increases their content in the blood plasma.
- In a joint application c buspirone reduces its effectiveness; from valproic acid - Activated its effects; from warfarin - Increases its concentration and the risk of bleeding; from galantamine - Intensified its negative effects; from haloperidol - Increasing the lithium content in the blood.
- Use of drugs with metoclopramide increased risk of extrapyramidal disorders.
- In a joint application with quinidine inhibited its metabolism and decreased clearance.
Terms of sale
The preparation is available by prescription only.
Storage conditions
Keep away from children. Store in a dry, dark place at a temperature less than 20 degrees.
Shelf life
Three years.
Cautions
Patients with depression and other states need to be constantly monitored by the treating physician until improvement occurs.
In patients with liver or kidney hypofunction treatment should start with small doses under the supervision of a doctor.
Care must be taken to appoint fluvoxamine persons with convulsive syndrome history. If the patient were frequent seizures or therapy should be discontinued.
Rarely using fluvoxamine (and other selective serotonin reuptake blockers) may occur hyponatremia Which disappears after discontinuation of the drug. The vast majority of episodes hyponatremia recorded in elderly patients.
The most common adverse effect of treatment fluvoxamine Nausea and vomiting, but they disappear after the first two weeks of therapy.
Perhaps the appearance of withdrawal symptoms when stopping treatment fluvoxamine . The most common symptoms experienced after cancellation fluvoxamine : Violation of the sensitivity, dizziness, sleep disturbances, irritability, agitation, confusion, headache, emotional instability, diarrhea , Nausea, vomiting, sweating, heart palpitations , Anxiety. Typically, these effects are mild and disappear on their own. They are observed in the first days after discontinuation of therapy. The Council therefore slowly lower the dose consumed fluvoxamine .
Luvox at a daily dose of 150 mg has no influence on the ability to drive. However, the period of treatment may develop drowsiness, so you should be careful until you examine individual responses to medicine.
Analogs Luvox
Paxil
Reksetin
Tsipraleks
Fluoxetine
The most common such analogs Luvox containing fluvoxamine , as Deprivoks and Sandoz Fluvoxamine .
Babies
Antidepressant Luvox is contraindicated in children under 8 years old.
During pregnancy and lactation
The use of drugs based on fluvoxamine Especially in the later stages, it can increase the possibility of developing persistent pulmonary hypertension in newborns . Therefore Luvox should not be used during pregnancy, unless the patient's condition does not require treatment with this drug.
The drug in small quantities can penetrate into breast milk, therefore the use of the drug to women during lactation is contraindicated.
Reviews of Luvox
Testimonials about Luvox and reviews of doctors are characterized by extremely contradictory. The number of negative reviews that you can read on the forums, often exceeds the number of positive - is associated with a high incidence of side effects. However, there are a sufficient number of patients completely satisfied with the effects of the drug. Keep in mind that Luvox and alcohol are incompatible, many of the negative effects caused by their co-administration.
Price Luvox
Price Luvox 50 mg (15 units) in Russia is 535-733 rubles, 15 tablets of 100 mg will cost 715-890 rubles. In Ukraine, the price Luvox 100 mg of the same form of release varies from 75 to 300 hryvnia, buy 50 mg tablet will cost about twice as expensive.
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