Laferobion

Description overdue on 07/10/2014

• Latin name: Laferobion
• ATC code: L03AV05
• Active substance: Interferon alfa-2b (Interferon alfa-2b)
• Manufacturer: Biopharma (Kiev, Ukraine)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Laferobion
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Lyophilizate solution and candles Laferobion children
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

• The composition of one candle Laferobion includes:
  recombinant human interferon alpha-2b   3 000 000 IU, 1 IU 000 000 500 000 150 IU or 000 IU, depending on dosage; ascorbic acid (vitamin C) ; tocopheryl acetate (vitamin E) ; tallow.
• One vial of lyophilisate for solution for injection of 1000000 IU, IU 3000000, 5000000 IU, IU 6000000, 9000000 IU or IU 18000000 Interferon alpha-2b   depending on the dosage. Adjuvants composed of lyophilisate: sodium chloride, dextran 70, potassium dihydrogen phosphate, sodium hydrogen phosphate, dodecahydrate .
• One vial contains a powder nasal 100000 or 500000 IU interferon alfa-2b   depending on the dosage. Excipients: sodium chloride, dextran 70, potassium dihydrogenphosphate, disodium phosphate dodecahydrate .

Product form

• Candles   produced in cell outline a package of 3, 5 or 10 pieces.
• The lyophilized powder   It is a white hygroscopic porous mass. By IU 1000000, 5000000 or 3000000 IU IU of such a powder in a plastic bottle, 10 such bottles in the package. Either of 6000000 IU, 9000000 or 18000000 IU IU in a plastic bottle, a bottle in one package. Also, there may be in multiples of 1 ml or 5 ml of water for injections in ampoules; the number of these ampoules is the number of bottles in the package.
• Nasal powder   It is a homogeneous mass of light color. 500,000 IU of the powder in the vial, a vial 1 and lid dropper packaging; or 100,000 IU of such a powder in a vial, 10 such bottles with cap-in a dropper pack.

Pharmacological action

The drug has immunomodulatory, anti-tumor   and Antiviral   activity without causing toxic effects.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

After injection of the drug interferon Included in its composition, will react with specific receptors on the cell wall and activates a cascade of intracellular events: production of proteins, inhibition of cell proliferation, stimulating phagocytic activity macrophages   and activity lymphocytes   with respect to the target cells, suppression of virus replication in infected cells.

Pharmacokinetics

The highest concentration after subcutaneous or intramuscular administration is observed in the blood after 3-12 hours after injection. The half - 3 hours.

Indications

The drug is used as a component of complex therapy of the following diseases:

• in neonates, including premature infants - pneumonia . SARS . sepsis . meningitis , Intrauterine infection ( herpes . visceral Candido h, Chlamydia . CMV infection . enterovirus infection . ureaplasmosis . mycoplasmosis );
• in pregnant women - urogenital infections (chlamydia, human papillomavirus infection, ureaplasmosis, CMV infection, bacterial vaginosis, trichomoniasis . mycoplasmosis . genital herpes . vaginal candidiasis . gardnerellez ) bronchopneumonia . pyelonephritis . SARS . chronic lung diseases, viral hepatitis C   and AT ;
• chronic hepatitis C, B, D   in adults and children, as well as in therapy cirrhosis   using hemosorption   and plasmapheresis ;
• chronic hepatitis C,   and D   children with cancer ( limfogranulomatoz . leukosis . solid tumors );
• Acute Hepatitis C   in children;
• perinatal   viral hepatitis C, B   and CMV   in children under 1 year;
• acute Hepatitis C   and AT   in adults;
• Flu   and SARS Including complicated superinfection In adults;
• herpetic   lesions of the skin and mucous membranes;
• HPV infection   ( genital warts, warts vulgar keratoacanthomas ).

Furthermore preparation showed high effectiveness in the treatment of:

• Flu   and SARS in children;
• Diabetes   (insulin) in children;
• Asthma   in children;
• viral and bacterial infections frequently and chronically ill children and adults;
• chlamydia, herpes, toxoplasmosis, ureaplasmosis, cytomegalovirus infection   in children and adults;
• glomerulonephritis   and pyelonephritis   in children;
• intestinal dysbiosis   in children;
• chronic gastritis   and duodenitis   in children;
• chronic inflammatory bowel disease in children character;
• serous meningitis   in children caused by enteroviruses ;
• Juvenile and rheumatoid rtrita ;
• Tick-borne encephalitis   in meningeal form;
• prostatitis   regardless of etiology;
• postoperative septic complications;
• parotitis a   various forms in children;
• Diphtheria   localized forms in children.

Contraindications

• allergy   to alpha-interferon Or other ingredients;
• autoimmune hepatitis ;
• pregnancy;
• decompensated liver disease;
• clearance creatinine   less than 50 ml / min;
• hemoglobinopathies history.

Side effects

• Perhaps the emergence of " influenza "Symptoms: fever,   myalgia, fever, asthenia , Fatigue, dizziness, arthralgia , Headaches, pain in the eyes.
• Common reaction: allergy, dehydration, hypercalcemia, hypothermia, hyperglycemia, lymphadenopathy, lymphadenitis, surface phlebitis , Peripheral edema, fatigue.
• On the side hematopoiesis : granulocytopenia, anemia, leukopenia, neutropenia, lymphocytosis, thrombocytopenia.
• On the side heart and vascular system : arrhythmia, angina, ventricular fibrillation, premature beats, tachycardia, bradycardia, hypotension.
• On the side Endocrine : virilism, hypothyroidism, gynecomastia, hyperthyroidism .
• On the side hepatobiliary system : hyperbilirubinemia, increased concentrations of liver enzymes and lactate dehydrogenase, a hepatitis.
• On the side digestive system : anorexia, diarrhea, stomach pain, nausea, vomiting, indigestion, gingivitis.
• On the side musculoskeletal system : arthrosis . hyporeflexia, arthritis, convulsions . atrophy of muscles, tendonitis, periarteritis nodosa, spondylitis.
• On the side urogenital : Amenorrhea, impotence, dysmenorrhea, urinary disorders.
• On the side Nervous System   and psyche : Paresthesia, depression, amnesia, gait disturbance and coordination, sleep disturbances, agitation, aphasia . apathy , Extrapyramidal disorder, hyperesthesia . tremor . migraine . polyneuropathy . dizziness .
• On the side Respiratory system : dyspnea , Cough, runny nose.
• On the side   skin : hair loss, dermatitis Itching.

Instructions on Laferobion

Instructions for use on candles Laferobion recommended by rectal administration.

The solution can be administered Laferobiona intravenous, intramuscular, intraperitoneal, endolymphaticly, rectally, parabulbarno, intravesically, podkonyuktivalno In also be used as nose drops or solution nebulizer . For injection are most commonly used in vials Laferobion 1000000 IU.

Instructions on Laferobion children indicates that for newborn and premature candles should be used at a dosage of 150 thousand. IU. In these cases, suppositories for children use one at a two times a day at intervals of 12 hours. Duration of treatment - 5 days.

In the complex treatment pneumonia   bacterial origin used in the newborn Laferobion 150,000 IU daily for one candle 3 times a day for a week.

Children age 4-6 months, you can assign Laferobion 500,000 IU 1 suppository 2 times a day, from 6 months - Laferobion 500 thousand. IU 2 candles twice a day.

In the complex treatment of chronic Hepatitis C . AT   and D   children drug prescribed to 3 million. IU interferon per square meter of body surface per day. The medicine is used every day for 1 suppository twice daily for 10 days and then in the same way a day of 6-12 months. The duration of treatment in this case is determined by clinical and laboratory parameters.

In the complex treatment of acute Hepatitis B   and FROM   adult drug dose 3000000 or 1000000 IU IU used in the stage of a long recovery, or in the case of long duration. Apply 1 suppository twice daily in one day. The duration of treatment is 4-6 months.

In chronic viral hepatitis   adults also nominated 3 000 000 or 1 000 IU 000 IU daily formulation 1 suppository twice daily for a week and a half, and then - for 6 months in a day (at hepatitis C ) Or one day to one year (at Hepatitis B ).

In the complex treatment SARS   and Flu   in adult candle Laferobion 500,000 IU appoint 1 thing twice a day for 5 days.

In the complex treatment of severe SARS   and Flu   children 1-7 years recommended spark 500,000 IU 7-14 years - candles 1,000,000 IU. Apply within 5 days 1 suppository twice daily.

With pyelonephritis   Candles 150 thousand. IU is used twice a day for a week and then for 2 candles in a day, once every three days for a month.

Nasal solution:   Drug treatment is most effective during the first few days of the disease. For therapy SARS   and viral-bacterial mixed diseases Laferobion used as a spray, inhalation or nose drops.

When backfilling the recommended dose of the drug - 5 drops (50,000-100,000 IU) both nasal passage not less than 6 times a day every 1, 5-2 hours. Duration of treatment - at least 2-3 days. Also effective inhalation Laferobiona.

Injection:   Available as a ready solution, lyophilisate and solution for the manufacture of its own.

A frequently asked question is how to breed Laferobion ampoules. This simple procedure: before using the contents of the vial must be diluted in water for injection 1 ml.

For the treatment of an acute form Hepatitis B   recommended to be administered to 1 million. Laferobiona IU twice daily for 6 days and then the dose is reduced to 1 million. IU daily for another 5 days. We do not recommend the use of the drug in cholestatic form of hepatitis   or hepatic coma .

In the chronic form Hepatitis B   use Laferobiona recommended dose of 3-6 million. IU every other day, a course of treatment - up to 24 weeks.

For therapy Tick-borne encephalitis   administration must be 1-3m. IU twice daily for 10 days followed by maintenance treatment is carried out by 1-3 million. IU every second day for 10 days.

When cancer therapy applied the maximum tolerated dose. Laferobion only has cytostatic effect, so you need to use it after remission or regression of the tumor.

When treating chronic myeloid leukemia   Laferobion used by 9 million. IU daily until remission, then move on to maintenance dose: 9mln. IU every other day.

With lymphocytic leukemia   recommended use Laferobiona 3 million. IU daily until improvement, then switch to maintenance treatment: 3 million. IU three times a week.

With Kaposi's sarcoma   It recommended the use of 36 million Laferobiona. IU daily for a long time. After stabilization is necessary transition to maintenance therapy of 18 million. IU three times a week.

Overdose

Overdose of the drug may lead to the development of lethargy , Disturbances of consciousness, prostration . These states are reversible and regress after discontinuation of the drug.

Cooperation

Laferobion compatible with all drugs commonly used in the treatment of the aforementioned pathologies ( chemotherapy drugs, antibiotics, immunosuppressants, corticosteroids, interferon inducers ).

Terms of sale

It sold only by prescription.

Storage conditions

Laferobion be stored at a temperature of 2-8 degrees in the refrigerator, away from children. The prepared drug solution can be stored for more than one day with the same conditions.

Shelf life

Three years.

Cautions

Do not study the effect of Laferobiona on ability to drive motor vehicles.

Alcohol and Laferobion incompatible.

Analogs

The most common drug analogues: Intron-A, Viferon, Lipoferon, Realdiron, Okoferon, Alfarekin, Bioferon, Genferon, Genferon Light .

Lyophilizate solution and candles Laferobion children

All forms of release of the drug approved for use in children and infants.

During pregnancy and lactation

Do not use this drug for the treatment of pregnant and lactating women. If drug therapy is necessary, the decision should be made based on an assessment ratio: benefits to the mother - the risk to the fetus.

Reviews Laferobione

Reviews Laferobion candles and other forms of release of the drug (drops and ampules with the solution) in most cases have a positive or neutral color. If you are using a medicine for children also received a positive assessment in the complex therapy of SARS, influenza and other diseases.

Price Laferobiona

Cost Laferobiona ampoules   (dilution) №5 po5mln. IU is 1353 rubles in Russia, in Ukraine - 246 UAH.

Cost preparation in the form of suppositories   in Russia for the packing of 5 pieces of 3 million. IU will average 871 rubles, 5 pieces of 500,000 IU - 351 rubles, and candles for children №5 150,000 IU will cost 264 rubles.

The price of candles Laferobion in Ukraine for the same dosage of 3 million packages. - 158 hryvnia, IU 500,000 IU - 64 hryvnia, 150,000 IU - 48 hryvnia.

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