Description overdue on 11/12/2014
- Latin name: Oftan Dexamethason
- ATC code: S01BA01
- Active substance: Dexamethasone (Dexamethasone)
- Manufacturer: JSC Santen, Finland
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
In 1 ml of drops contain: 1 mg Dexamethasone + Extras ( boric acid, edetate disodium, benzalkonium chloride, sodium tetraborate, water ).
Product form
The drug produced in vials of 5 ml polyethylene. The drug - a clear liquid, colorless and odorless. In a cardboard bundle one bottle.
Pharmacological action
The anti-inflammatory .
Pharmacodynamics and pharmacokinetics
The active substance - is glucocorticosteroid . Its anti-inflammatory activity is due to the ability to inhibit the vital activity adhesive molecules endothelial . cyclooxygenase 1 or 2, and selection Cytokine . This reduces the intensity of formation inflammatory mediators , Inhibited adhesion leukocytes to vascular endothelium , Mediators can not migrate to inflamed parts of the eye.
Pharmacokinetic parameters such as the maximum concentration, and the period of excretion were observed in patients who underwent surgery to remove Cataract . At the same time, the maximum drug concentration was reached within 2 hours, and elimination period is 3 hours.
Dexamethasone It is metabolized in the body. About 60% of the metabolites derived through the kidneys for 3-4 hours. Bioavailability is 70%, the degree of binding of active substance with proteins in the blood - 80%.
Indications
Eye drops Oftan Dexamethasone is prescribed:
- for the treatment of acute and chronic inflammation of the eye ( keratitis, conjunctivitis, blepharitis, scleritis, keratoconjunctivitis sicca, episcleritis );
- at uveitis of different origin, iritis . iridocyclitis ;
- for superficial injuries corneal of different origin;
- at sympathetic ophthalmia . choroiditis . chorioretinitis ;
- treatment ketatokonyunktivita or allergic conjunctivitis ;
- as prophylaxis and treatment of inflammation after operation and injury.
Contraindications
The tool does not prescribe:
- children and adolescents;
- at allergies at any of its components;
- at tuberculosis eyes;
- at keratitis Caused by a virus (eg, Herpes );
- for treating other diseases corneal or conjunctiva , Viral;
- when damaged epithelium cornea, including after removing therefrom foreign body;
- during acute purulent eye diseases;
- fungal or mycobacterial eye diseases;
- at epitheliopathy cornea ;
- if the patient has an increased intraocular pressure ;
- at glaucoma .
Side effects
Benzalkonium chloride It can irritate the eyes and be allergen .
Immediately after instillation may experience a burning sensation or allergic reaction.
Also available:
- development of secondary Glaucoma or Cataract (caused by taking Steroids );
- sores, or clouding thinning of the cornea;
- appearance to the eye (or spread) Herpes or bacterial infection.
Instructions for use (method and dosage)
Medicine to take podkonyunktivalno .
Before use, the vial should be well shaken.
The dosage and duration of treatment should be determined by the attending physician.
According to the instruction on Oftan Dexamethasone during acute period prescribed by 1-2 drops in the affected eye (s), every half-hour or an hour, then the receiving means is performed in a mode 1-2 drops every 2-4 hours. The dosage can be reduced to 1 drop 3-4 times per day.
If within 3-4 days of improvement does not occur, the diagnosis should be reconsidered or replaced by medication.
During treatment should be monitored intraocular pressure .
Adjustment daily dosages for patients with liver or kidney disease due to low systemic absorption means are required.
Overdose
With the right (local) application of a drug overdose probability is extremely small.
In very rare cases can occur irritation of the eyes.
In case of overdose should wash eyes with running water. Specific antidote medicine has no therapy is symptomatic. If symptoms recur, the drug should be canceled.
Cooperation
Due to the fact that the drug is able to induce isoenzyme CYP3A4, care must be taken in combination with the drug BPC . erythromycin and quinidine .
The tool can enhance the action warfarin . phenytoin and barbiturates .
When taking other eye drops or ointments to do 15-minute break between applications.
Terms of sale
It requires a prescription.
Storage conditions
In a place protected from unwanted intrusion children at 2 to 8 degrees.
Shelf life
2 years. Upon initial use (opening) - 30 days.
Cautions
The drug is intended for ophthalmological use.
Corticosteroids It should not take more than 2 weeks, the risk increasing Intraocular pressure , Development Glaucoma (with the defeat of the optic nerve), loss of visual acuity. Damage to the surface of the cornea slowly tightened, and the probability of viral or bacterial, fungal diseases increases.
During treatment, you should not wear contact lenses. At least, they should be removed before and put on 15 minutes after instillation with eyes.
Analogs
Metazon
Dexamethasone
The closest analogues: Deksmetazona phosphate deksapos, Medeksol, Deksazon, Maksideks, Oftan dexa chlora, Farmadeks, Deksmetazon VFZ, Ozurdeks, Hydrocortisone .
During pregnancy and lactation
Do not use drops of pregnant and nursing women.
Reviews
Reviews of Oftan Dexamethasone eye drops a little, but of those that are most - good. The drug is often used to reduce inflammation while wearing lenses konaktnyh at conjunctivitis . The drug is quite effective and inexpensive.
Price Oftan Dexamethasone
Price Oftan Dexamethasone eye drops is 95 rubles for a bottle of 5 ml.
No comments:
Post a Comment