Siofor

Description overdue on 04/29/2014

• Latin name: Siofor
• ATC code: A10BA02
• Active substance: Metformin (Metformin)
• Manufacturer: Berlin-Chemie AG / Menarini Group (Germany)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Instructions on Siofor (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Synonyms
• Analogs
• Babies
• With alcohol
• Slimming
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The preparation Siofor 500   It is composed of 500 mg of metformin hydrochloride   (active ingredient), and povidone . silica . magnesium stearate . macrogol   (additional substance).

Siofor 850   It contains 850 mg of   metformin hydrochloride and similar additional substances. Siofor 1000 comprises 1000 mg of metformin hydrochloride Additional and similar substances.

Product form

Siofor available as white oblong tablets. They are coated and have a notch to divide the two sides. Packed in blisters of 15 pieces.

Pharmacological action

Siofor a hypoglycemic drug that belongs to a group biguanide . The drug has anti-diabetic effects. It contributes to the inhibition of glucose absorption from the gastrointestinal tract, increases the insulin sensitivity of peripheral tissues, slows gluconeogenesis . Under the influence of the drug activates muscle glucose utilization. Siofor also has a positive effect on lipid metabolism due to the lipid-lowering effects and clotting due to fibrinolytic effects.

The drug reduces the level of glucose in the blood, thereby reducing body weight in humans who suffer diabetes It reduces appetite.

Pharmacodynamics and pharmacokinetics

The maximum drug concentration achieved after 2 and 5 hours after oral administration. If the drug is taken together with food slows the absorption and decreases. In healthy people, bioavailability of about 50-60%.

The active substance is almost bound to plasma proteins.

Withdrawal occurs in unchanged in the urine. The half-life after oral administration is about 6.5 hours.

If the patient has reduced kidney function, half-life is increased, so increases in the plasma concentration metformin .

Indications

Tablets Siofor indicated for use in the treatment of diabetes of the second type, especially if the patient says obesity And diet and exercise is not enough to compensate the metabolic processes.

Contraindications

Contraindications The drug should be:

• Hypersensitivity;
• diabetes first type ;
• diabetic ketoacidosis ;
• diabetic precoma . coma ;
• cessation of endogenous insulin secretion in patients with Type II diabetes;
• renal, hepatic, respiratory failure;
• myocardial infarction   in the acute phase;
• severe infectious disease;
• injuries and operations;
• hypoxic conditions;
• enhanced decay processes in an organism (tumor et al.);
• lactic acidosis ;
• alcoholism;
• diet   with a strictly Limited-calorie (less than 1000 calories daily);
• children's age;
• pregnancy, breast-feeding.

Side effects

When receiving Siofor, the following side effects:

• The system of the digestive tract: the beginning of treatment may feel a metallic taste in the mouth, appetite loss, vomiting, abdominal pain, and diarrhea. In the treatment of side effects such fade.
• In the hematopoietic system: very rarely can develop megaloblastic anemia .
• Skin: in rare cases develop allergic reactions .
• In rare cases, it may be a manifestation lactic acidosis .

Instructions on Siofor (method and dosage)

In general, the tablets are taken orally, their need to drink large amounts of water, not chewed. Dosage assigned physician depending on whether the blood sugar level is detected in the patient.

Instructions on Siofor 500   following: originally appointed a day 1-2 tablets, the daily dose is increased gradually to three tablets. The largest dose a day - six tablets. If a person takes a day more than one pill, you must divide them into several stages. You can not increase the dosage without first consulting your doctor. The duration of treatment is determined by a specialist.

Instructions for use   Siofor 850 as follows: initially the drug starts with one pill. Gradually dose may to increase until 2 tablets. At night you can take no more than 3 tablets. If the day is taken more than one tablet, it is necessary to divide them into several times. You can not increase the dosage without first consulting your doctor. Duration of treatment establishes only a specialist.

Instructions on Siofor 1000 the following: receiving one starts with a tablet a day can be taken no more than 3 tablets. Sometimes it is necessary to combine the intake of drugs with insulin. You can not use Siofor diet without consulting a doctor.

The drug at polycystosis ovarian   It is possible only after the approval of the treating doctor.

Overdose

When studies were observed symptoms hypoglycemia   even if adopted dose exceeds 30 times daily. Overdose can lead to Lactic acidosis . Symptoms of this condition is vomiting, diarrhea, weakness, rapid breathing, loss of consciousness. In this case, hemodialysis. But often eliminate the symptoms enables the reception of glucose or sugar.

Cooperation

If Siofor taken simultaneously with other antidiabetic drugs, NSAIDs, MAO inhibitors, fibrates, ACE inhibitors, insulin, it is important to carefully and regularly monitor the level of glucose. In this case, could increase hypoglycemic properties Siofor.

The effectiveness of the drug can be reduced if it is taken in combination with the thyroid hormone, corticosteroids, progesterone . Estrogen , Thiazide diuretics, sympathomimetics, and with nicotinic acid . In this case, important control of blood glucose levels, a correction dose Siofor.

Simultaneous treatment cimetidine   It can enhance the probability of lactic acidosis .

Terms of sale

The tablets are dispensed by prescription of the doctor.

Storage conditions

Store the drug must be at a temperature not exceeding 25 degrees Celsius. Keep medication away from children.

Shelf life

It can be stored for 3 years.

Cautions

In the period of treatment must be very carefully monitor the patient's kidney function.

If you plan to radiological examination, the drug must be suspended before the test and did not take the drug even after two days of the survey, since the introduction of contrast can provoke renal failure .

Admission Siofor necessary to stop two days before the planned surgery to be carried out under general anesthesia. Treatment may continue for two days after surgery.

Do not combine the reception of funds from those drugs that increase hypoglycemic impact .

Gently apply the medicine for the treatment of elderly people who are 65 years of age.

It is recommended to control the level of blood lactate twice a year. If reception Siofor be combined with other drugs to lower blood sugar levels, a person may be violated ability to manage traffic.

Synonyms

Glucophage . Metformin . Glucophage XR . Metfogamma . Diaformin . Metformin hexane .

Analogs

Match code ATC 4th level:

• Glyukofazh Long
• Glucophage
• Metformin

Analogs are sometimes used as a replacement Siofara. The following analogues: Metformin . Metfogamma . Formetin . Glucophage . They contain similar active ingredient, so their effect on the body is similar. But substitute drug analogues can only specialist.

Which is better: Siofor or Glucophage?

Glyukofazh contains as active ingredient metformin hydrochloride, and is used both as a mono therapy in Type II diabetes, as well as in integrated treatment. However, this drug as Siofor not only used as a means to reduce weight. So the question is, what is best for weight loss in this case is incorrect.

Metformin or Siofor - which is better?

Both drugs belong to the group of oral hypoglycemic of medicines and can be interchanged after approval by physician. The usefulness of this or another drug the doctor determines an individual basis.

Babies

To date, there are no clear clinical evidence, so the drug is not used to treat children.

With alcohol

Compatible with alcohol is bad. Possible lactic acidosis   Siofor the treatment and alcohol intake. Reviews testify to the you feel unwell of people, combines alcohol and this drug. There is also an increased risk of hypoglycemia.

Slimming

The drug is effective in reducing blood glucose levels, and in the first place it is administered to humans diabetes Who are obese. However, doctors do not support those who use Siofor exclusively for weight loss. However, reviews of Siofor slimming show that primarily the drug reduces the desire to eat sweets.

Those who are evading the forum about how to combine Siofor Siofor 500 or 850, and weight loss, note that the weight reduction is very fast, especially when combined with a decrease in caloric intake and physical activity. However, those who take diet pills and the side effects observed - cramps . fermentation in the stomach , Frequent and loose stools, nausea .

But if people still decided to try this method of weight loss, need clear instructions on how to take Siofor slimming. In this case, a drug with a minimum dose of active substance - 500 mg. Tablets need to use or during a meal, or before a meal.

If diet while taking the drug, should be limited to one pill per day. Do not take medicines if coming heavy loads, combine it with other drugs for weight loss, laxatives . diuretic drugs . It should stop the treatment at a high temperature, expressed violations of the gastrointestinal tract. We do not recommend taking the drug for more than 3 months.

When pregnancy

Pregnancy is a contraindication for receiving Siofor. The drug is contraindicated during pregnancy. When planning a pregnancy, drug treatment and is not recommended.

Reviews Siofor

Reviews doctors Siofor 1000 850 500 in the most positive, but experts emphasize on the fact that the drug should be made solely of patients with diabetes, but not healthy slimming people. The medicine helps to effectively restore normal blood sugar and, in addition, people with diabetes taking Siofor 850 or other drug doses, say weight reduction.

In a network can be find many have user reviews lost weight with the help of this means of, who claim, that when of his reception really decreases appetite. But reviews Siofor 500 with diabetes, as well as the opinions of those who took it for weight loss, are the same that after the cessation of treatment the weight usually returns quickly. It marked by the fact that the tablets have an acceptable price. However, there are also a lot of negative reviews about the side effects that develop in the course of such therapy. In particular, it is a problem in the functioning of the liver, pancreas, intestine, stomach.

Price Siofor where to buy

Cost Siofor 500 mg   It is about 240-260 rubles.

Buy Siofor 850 mg   It can cost 290 - 350 rubles.

Cost Siofor 1000 mg   an average of 380 - 450 rubles.

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