Description overdue on 08/12/2014
- Latin name: Amaryl
- ATC code: A10BB12
- Active substance: Glimepiride (Glimepiride)
- Manufacturer: Aventis Pharma Deutschland GmbH (Germany)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications Amar
- Contraindications
- Side effects
- Instructions on Amaryl (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
One tablet of the preparation comprises an active substance - glimepiride - 1-4 mg and auxiliary ingredients: lactose monohydrate, povidone, sodium carboxymethyl starch, microcrystalline cellulose, magnesium stearate, and indigo.
Product form
Amaryl is produced in tablets containing 1-4 mg, 15 are packaged in blister units. One pack of the drug may include 2, 4, 6 or 8 blisters.
Pharmacological action
Tablets Amaryl have hypoglycemic action.
Pharmacodynamics and pharmacokinetics
Receiving glimepiride It reduces the concentration of glucose in the blood, due to the stimulation of the release of insulin of beta cells in pancreas . This effect is related to the improved response of beta cells of the pancreas to stimulate glucose-physiological.
Regulation of secretion insulin It occurs due to interaction with the ATP-sensitive potassium channels located in the membranes of the beta cells. Glimepiride selectively binds to proteins and regulates the activity of the ATP-sensitive potassium channels, ie their opening or closing.
If patients lack metabolic control while taking the maximum dose glimepiride , It is possible combination therapy glimepiride and metformin . This leads to a significant improvement of metabolic control, when compared with the use of these drugs alone. Also allowed simultaneous therapy insulin . In this marked improvement in metabolic control, similar to the use of only one of insulin, but in such cases, a reduced dosage of insulin.
Multiple reception glimepiride For example, 4 mg per day, leads to a maximum concentration of the substance in the blood, which is reached after 2 to 5 hours.
Ingestion contributes to the overall absolute bioavailability of the active ingredient. Eating food has little effect on the absorption of slightly slowing its speed. Displayed glimepiride via the kidneys and intestines. As part of the urine as unchanged drug is detected. In the body, glimepiride metabolizes in the liver with the help of CYP2C9 in two metabolites - hydroxy compound and the carboxy derivative. Inside the body is not a marked accumulation of active substance.
Indications Amar
As a rule, this medicine is prescribed for type 2 diabetes . This remedy for diabetes may be used for monotherapy or in combined treatment with both insulin or metformin .
Contraindications
There is a fairly large list of contraindications to the reception Amar:
- type 1 diabetes;
- severe disorders of the liver and kidneys;
- diabetic ketoacidosis, coma and precoma,
- lactation, pregnancy;
- the presence of rare hereditary diseases, such as galactose intolerance, glucose-galactose malabsorption or lactase deficiency;
- children's age;
- intolerance or sensitivity to the drug and so on.
Caution required for initial treatment of patients, since at this time there is a risk of hypoglycemia. If there is likely to hypoglycemia, it is often necessary to adjust the dose glimepiride or therapeutic scheme. In addition, special attention is required the presence of intercurrent and other diseases, lifestyle, nutrition and so on.
Side effects
In the treatment of Amarillo can develop a variety of adverse events, one way or another affect the activities of almost all body systems. Often side effects are hypoglycemia, symptoms of which are expressed: headache , Hunger, nausea . vomiting . Feeling tired . sleepiness . depression . confusion and many other symptoms. Sometimes the clinical picture of severe hypoglycemia resembles a stroke. After her elimination completely disappear and undesirable symptoms.
In the initial treatment may experience eye problems, digestive system, hematopoiesis. It is also possible to develop allergic reactions Which can move in complications. Therefore, the appearance of unwanted symptoms you should immediately consult your doctor.
Instructions on Amaryl (method and dosage)
Tablets are intended for internal use, in whole, without chewing and drinking plenty of fluid.
Typically, the dose is determined by the concentration of glucose in the blood. For the treatment administered the lowest dose which aids in achieving the necessary metabolic control
Also, instructions for use Amara said that the treatment requires regular determination of the concentration of blood glucose and glycosylated hemoglobin.
Anyone receiving the wrong pills, like skipping the next dose is not recommended to fill an additional dose. Such situations need to specify in advance with your doctor.
At the beginning of the treatment of patients prescribed daily dose is 1 mg. If the need arises, the dosage is gradually increased by performing regular control of blood glucose concentration according to the scheme: 1 mg 2 mg 3 mg 4 mg 6 mg 8 mg. The usual daily dosage for patients having a good control Diabetes Is 1-4 mg of active substance. A daily dose of 6 mg effect produces only a small number of patients.
The daily dosage regimen of the drug sets doctor, as this is necessary to take into account various factors, such as meal times, the amount of exercise and more.
Often appointed by taking the drug once daily, to a full breakfast or the first main meal consumption. It is important that after taking the pills do not skip meals.
It is known that improvements in metabolic control is related to increasing insulin sensitivity, and in need of treatment Glimepiride It may be reduced. To avoid hypoglycemia, you can with the help of timely dose reduction or discontinuation Amar.
During the therapeutic process of dosage compensation glimepiride It can be carried out at:
- reducing the weight of the patient;
- lifestyle changes;
- occurrence of other factors leading to predisposition to hypoglycemia or hyperglycemia.
Generally, treatment is carried out for a long time Amarillo.
Overdose
In cases of acute overdose or prolonged use of high doses glimepiride may occur development of severe hypoglycemia, which is a threat to life.
Upon detection of an overdose of an urgent need to go to the doctor. Hypoglycemia is possible to stop intake of carbohydrates, such as glucose or a small piece of any sweets. Prior to the complete elimination of the symptoms of hypoglycemia patient requires careful medical monitoring, since undesirable effects could resume. Further treatment depends on the symptoms.
Cooperation
Simultaneous treatment with glimepiride with certain drugs can cause hypoglycemia, for example, Insulin and other hypoglycemic agents, ACE inhibitors, anabolic steroids and male sex hormones, chloramphenicol, derivatives Coumarin, cyclophosphamide, disopyramide, fenfluramine, Feniramidolom, fibrates, fluoxetine, guanethidine, ifosfamide, MAO inhibitors, fluconazole, para-amino salicylic acid, phenylbutazone, azapropazone, oxyphenbutazone, salicylates, sulfinpyrazone, clarithromycin, sulfonamides, tetracyclines and others.
Receiving Acetazolamide . barbiturates . GCS . diazoxide . diuretics . Epinephrine and other sympathomimetic agents, Glucagon , Laxatives (after prolonged use) nicotinic acid (in high doses) estrogen and progestogens, phenothiazines, phenytoin, rifampin, iodine-containing thyroid hormones causes a weakening of hypoglycemic effect, and thus increases the concentration of glucose in the blood.
Strengthen or weaken the hypoglycemic effect of glimepiride capable blockers H2 histamine receptors, Clonidine . Reserpine . Coumarin and beta-blockers.
Terms of sale
In pharmacies, drug prescription.
Storage conditions
For storage Amar necessary dark, protected from the children, with temperatures up to 30 C.
Shelf life
3 years.
Analogs Amar
Manin
Diabeton
Modern pharmacology offers many tools such action. However, the most common analogs Amaro - is Amaryl M Glemaz, Glemauno, Diamerid and Meglimid .
Alcohol and Amaryl
During treatment with this drug, especially at first, you must give up the use of alcohol. The fact that both single and chronic drinking can significantly strengthen or weaken the hypoglycemic effect glimepiride .
Reviews Amarillo
Numerous reviews of patients and professionals suggests that the treatment of diabetes is of particular importance competent selection of dosing and therapeutic schemes.
This Amarillo reviews show that this drug is not for everyone with diabetes. Quite often the initial treatment of patients there is an abrupt change in the content of sugar in the blood. However, experts believe that in such cases require a dose adjustment upward and it's not an indication of the ineffectiveness of the drug.
Of course, any adjustments related to both increase and decrease the dosage to be carried out under the close supervision of a specialist. It was found that illiterate reception Amar can cause complications of the disease.
Price Amara, where to buy
In pharmacies, the drug is available in several versions, with different contents of active substance. The drug costs on average - 238-286 rub., The price Amaryl 4 mg - 868-1080 rubles., 3 mg - 633-829 rub. and 2 mg - 453-562 rub.
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