Ursosan

Description overdue on 10/12/2014

• Latin name: Ursosan
• ATC code: A05AA02
• Active substance: Ursodeoxycholic acid (Ursodeoxycholic acid)
• Manufacturer: PRO.MED.TSS Prague (Czech Republic)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications ursosan
• Contraindications
• Side effects
• Instructions for use ursosan (method and dosage)
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Analogs
• Newborns
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The composition of the following medications:

• active ingredient -   ursodeoxycholic acid ;
• Additional components - corn starch . colloidal silicon dioxide . gelatin .   magnesium stearate . Titanium dioxide .

Product form

The drug is sold in Ursosan hard capsules white. Inside the capsule white powder.

Pharmacological action

The drug is hepatoprotective He also works as a zhelchegonnoe . gipolipidemicescoe . immunomodulatory . cholelitolitic   and hypocholesteremic means.

Pharmacodynamics and pharmacokinetics

The composition determines the effect of this drug. Its active ingredient - ursodeoxycholic acid . Wikipedia and many other sites are called the drug that way. Ursodeoxycholic acid   has high polar properties and creates toxic mixed micelles   toxic bile acids. This leads to the fact that reduced ability gastric reflyuktata   damage cell membranes with the appearance of reflux esophagitis   and biliary reflux gastritis . In addition, the drug creates a double Ursosan molecules that make the cell membranes hepatocyte . epithelial   Gastrointestinal tract, cholangiocytes . These molecules stabilize them and make impervious to the influence of cytotoxic micelles .

Active drug substance also reduces the content of bile acids, which are toxic to hepatocyte And stimulates cholepoiesis , Saturated sodium bicarbonate. This eliminates intrahepatic cholestasis . Ursodeoxycholic acid   decreases lithogenic index   and the concentration of bile cholesterol   by preventing its absorption in the gut, reducing the secretion of bile, inhibition of synthesis in the liver. As a result, dissolve cholesterol   gallstones. The facility also prevents the emergence of new concretions .

The drug acts as a immunomodulatory   by means of the expression of oppression antigens HLA-2   and HLA-1   and improve normal   killer   activity lymphocytes . In addition, it prevents the development of fibrosis   in humans with primary biliary cirrhosis As well as alcoholic steatohepatitis   and cystic fibrosis . It reduces the likelihood of Varicose Veins   in the esophagus, retards premature aging and cell death.

The active drug substance is absorbed from the small intestine by passive diffusion (degree Absorption   approximately 90%) and in the ileum - due to active transport. The maximum concentration is reached after about 60-180 minutes.

The degree of association with the plasma proteins and 99%. With constant use ursodeoxycholic acid   It becomes the main bile acid in serum. The therapeutic effect of the drug depends on its content in the bile.

The drug is cleaved in the liver to form these products metabolism , as glycine   and   taurine conjugate . They secreted   in bile. Approximately 60% of the dose excreted in the bile. A certain amount of active substance is also transported to the colon, where bacteria cleaved. Lithocholic acid   to a small extent absorbed from the colon, sulfated   in the liver and excreted as a   sulfolitoholilglitsinovy   or sulfolitoholiltaurinovy ​​conjugate .

Indications ursosan

The forums are often interested in, from what pills can help in some way. Experts do not recommend taking them without consulting your doctor. Only he can determine whether there is evidence for use ursosan. In addition, it selects the appropriate treatment regimen.

If you have appointed a tablet Ursosan, indications for use, as a rule, the following:

• uncomplicated cholelithiasis ;
• the need to prevent the recurrence of stone formation after Cholecystectomy ;
• sharp hepatitis ;
• alcoholic disease and primary biliary cirrhosis ;
• dyskinesia   biliary tract;
• Cystic fibrosis ;
• biliary dyspeptic syndrome ;
• toxic liver damage;
• chronic active hepatitis ;
• NASH ;
• atresia   intrahepatic biliary tract;
• primary sclerosing cholangitis ;
• biliary reflux gastritis   and reflux esophagitis ;
• the need for the prevention of liver damage while taking hormonal contraceptives and cytostatics .

Contraindications

This drug should not be used in case of hypersensitivity to its components, not functional gallbladder, chronic hepatitis . pancreatitis , Acute cholecystitis . cirrhosis (decompensated) , Acute cholangitis , An acute infectious disease of the gallbladder, bile duct disease, pregnancy . breast-feeding . bile-gastrointestinal fistula , Gallstones with increased content of Ca2 +, inflammatory diseases of the small and large intestine, hepatic insufficiency . renal failure . empyema   gallbladder, obturation   biliary tract.

Side effects ursosan

Reviews side effects occur infrequently. However, if you experience any adverse reaction, you should always consult a doctor.

Known side effects ursosan:

• vomiting;
• exacerbation psoriasis ;
• nausea;
• diarrhea ;
• transient increase in liver transaminases ;
• constipation ;
• pain in the back;
• allergy ;
• alopecia .

In rare cases it is possible calcination   gallstones.

Instructions for use ursosan (method and dosage)

Those who appointed Ursosan pills, according to instructions for use that they need to take orally , With some liquid.

The drug has different regimens, depending on the disease. For those interested in how to make Ursosan: before meals or after - also reported that it individually, depending on indications.

When diffuse liver diseases   and cholelithiasis   treatment can last from several months to several years, the daily dosage is usually 10-15 mg per 1 kg of body weight (2-5 capsules). At cholelithiasis   once daily dosage taken just before bedtime. Treatment is carried out to dissolve the stones, and then a further 3 months to the rocks did not form again. At diffuse liver diseases   Instructions for use ursosan reported that the daily dosage should be divided into 2-3 doses. Means should be taken during meals.

After Cholecystectomy   and to prevent re- cholelithiasis Usually 250 mg administered two times a day. The course lasts for several months.

In primary biliary cirrhosis   drug taken in a dosage of 10-15 mg per 1 kg of patient body weight per day. If necessary, it can be increased to 20 mg per 1 kg. The dosage should be divided into 2-3 doses. The course of treatment lasts from 6 months to several years.

If the patient NASH Take 13-15 mg per 1 kg of body weight per day. The dosage should be divided into 2-3 doses. The course of treatment can last from 6 months to several years.

When biliary reflux gastritis   and reflux esophagitis   medicine is taken 1 capsule (250 mg) per day just before bedtime. The therapy is carried out from 10 days to 6 months. If there is a necessity, it can be extended to 2 years.

At liver damage . atresia   and biliary tract alcoholic liver disease   daily dosage is usually 10-15 mg per 1 kg of patient weight. The daily dose should be divided by 2-3 hours. The course lasts for six months, a year or more.

If the patient has primary sclerosing cholangitis , The doctor prescribes typically 12-15 mg per 1 kg of patient body weight per day. If necessary dosage can be increased to 20 mg per 1 kg weight. The total daily dose is divided into 2-3 doses a patient. The course of treatment - from six months to several years.

At cystic fibrosis   the drug is taken in dosages of 20-30 mg per kg per day. The dose should be divided by 2-3 hours. The course lasts from six months to several years.

For children from 2 years the number of receiving the drug on the day established expert individually. Typically prescribed 10-20 mg per kg per day.

In order to alleviate severe and dangerous jaundice   Specialists in some cases, prescribe the tool and newborns. Therapy for 2-4 weeks. Instructions for use ursosan newborns reported that the dosage for children of this age - a quarter of a capsule every day. The powder, which is in it, poured on a saucer. Then it is divided into four equal parts, one of which is given to an infant. Previously it to be dissolved in water or human milk. If treatment is successful, the course may be shortened to 10 days. It should be every week to watch the content bilirubin   in blood. The average weekly its level reduced by 50 units. After concentration in blood would be 100 mg / ml, the drug can be canceled.

Overdose

About overdose with this drug have been reported.

Cooperation

Antacids   and with Al3 + ion exchange resins   able to reduce the extent of absorption of the drug. Lipid preparations Estrogens , and Neomycin   or progestins   increase the level of cholesterol   bile and reduce the dissolution rate cholesterol gallstones .

Terms of sale

The drug is released only by prescription.

Storage conditions

Keep the capsules need to dry, out of reach of children and well-protected against the penetration of sunlight. The optimal temperature with 25 ° C.

Shelf life

Four years.

Analogs ursosan

Match code ATC 4th level:

• Urdoksa
• Livodeksa
• Ursol
• Ursofalk

Name analogues of the drug is presented in the following list:

• Ursolak ;
• Ursol ;
• Ursolizin ;
• Ursomaks ;
• Ursonost ;
• Ursofalk ;
• Ursohol ;
• Essentiale ;
• Choludexan .

All counterparts ursosan have their own characteristics and application of. None of them can be replaced independently without consulting your doctor. Price analogs may vary depending on the amount of drug in a single package. However, in most cases their value is higher than the drug described in the same amount.

Consider some analogues ursosan more.

Ursofalk or Ursosan - which is better?

Most experts consider when choosing between these two preparatmi that it is better to first means. This is confirmed by many clinical observations, reviews of patients and long-term practice. People taking both agents, noted that Ursofalk   transferred more easily. And experts report that he will dissolve gallstones, and improves the condition of the liver. However, what is the difference Ursosan   and Ursofalk   for each case, it can only be understood in practice. There are people for whom it is right for such a medicine as Ursosan. So you can set first course Ursofalk And if the treatment was not effective enough to move to another drug. Thus, you can choose the best method of treatment.

Ursosan or Essentiale - which is better?

As hepatoprotector Essentiale   It is much more effective to maintain the functions of the liver. Furthermore, this agent has as many side effects. So for those who choose the medication if necessary normalization of liver function in most cases, doctors recommend a second agent. Ursosan is more expensive and the cellular structure has less effect.

Urdoksa or Ursosan - which is better?

Urdoksa   - A means of domestic production, which is the generic   Ursosan. However, all the necessary components for its production are purchased abroad. Thus, all components therein are the same as in the original formulation. So the answer to the question " Urdoksa   or Ursosan - which is better? " - does not exist. In fact, a complete analog, and the difference between them is only in the country of origin. Many, however, the domestic tool is selected, since its cost is much smaller.

Ursol or Ursosan - which is better?

Both drugs have the same basic components. Some patients seem to tolerate a single drug, and some - other. In this situation, the individual performance can only be tested in practice. It all depends on the characteristics of the body, so you should start taking one of the means, and if it does not work, go to another. Objective evidence to help determine the effectiveness of each of these drugs do not exist. Many patients prefer to try every means, and then choose the most effective.

Ursosan for newborns

Reviews of this drug suggests that it with appropriate evidence is effective for newborns. At high concentrations bilirubin   in the blood of infants may develop physiological jaundice .

Ursosan in this case has its own set of application circuit.

With alcohol

Since the drug is among the indications Alcoholic liver disease , It was tested for compatibility with alcohol. After all, the people who make this tool, it is difficult to give up the addiction, even if it has already affected the body adversely. Investigations have revealed that the drug loses its efficacy in alcoholic beverages. This is supported by improved blood biochemical parameters in people with this addiction.

Ursosan during pregnancy (and lactation)

At pregnancy   This medication is recommended to take only when the intended benefits to women than the potential risk for the baby.

During breast-feeding   to use the tool is not desirable, since there is no data on the interaction of its active substance in breast milk.

Reviews ursosan

Reviews of drug treatment can often be found in specialized forums. In particular, they express their opinions and physicians. They note effectiveness of the drug. Testimonials are also predominantly positive. Some accept it, and as a preventive measure in cases where the expected large load on the liver.

In regard to the application for newborns, reviews about ursosan doctors tend to report that the treatment was effective. Parents turn to him with the appearance of children jaundice . Those who gave the drug, respectively, the provisions of the specialist, leave reviews ursosan, which states that the drug helped.

Price ursosan where to buy

This medicine can be bought in Ukraine, Belarus and Russia. How much does this drug depends on the number of capsules, in the same package. Average price ursosan in Ukraine:

• Capsules of 50 pieces per pack - 370 hryvnia;
• Capsules of 100 pieces per pack - 640 hryvnia;
• Capsules of 10 pieces per pack - 70 hryvnia.

The cost of the drug in Minsk and other Belarusian cities:

• Capsules of 50 pieces in the package - about 300 thousand. Br;
• Capsules of 10 pieces in the package - about 70 thousand. rubles.

Buy in Moscow and other Russian cities, the tool can be at the following rates:

• Ursosan price of 100 tablets (250 mg) - about 1400 rubles;
• Price ursosan 50 capsules - about 770 rubles;
• price per pack of 10 capsules - about 180 rubles.

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