Description overdue on 03/26/2014
- Latin name: Groprinosin
- ATC code: J05AX05
- Active substance: Inosine pranobex
- Manufacturer: LLC "Gedeon Richter Poland", Poland
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Groprinosina (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Analogs
- With alcohol
- Reviews
- Price, where to buy
Composition
In the 1 tablet Groprinosina (Groprinosin) contains:
- inosine pranobex - 500 mg (active ingredient);
- Excipients: povidone K25 . stearate Magnesium , potato starch .
Product form
Tablets Groprinosin white (sometimes almost white), have an elongated shape and risk on one side. This drug is manufactured by 10 tablets in a blister, cardboard packaging to be 2 or 5 blisters.
Pharmacological action
The drug is used as an immunostimulatory and antiviral agent.
Pharmacodynamics and pharmacokinetics
Groprinosin is an immunostimulant drug having the same antiviral effect. This drug is effective because it contained inosine And a second component thereof ( salt steam-acid atsetamidobenzoynoy ) Can increase the level of accessibility of inosine for lymphocytes. It blocks the proliferation of virus particles.
Groprinosin can also be assigned as an additional remedy for the incidence of virus Herpes simplex skin and mucous membranes. In this case, a more rapid healing, decreases the severity and duration of disease with topical preparation.
Tablets quickly and more than 90% absorbed, have high bioavailability. After 1 hour, maximizes the concentration of active substance in plasma half-life is about 50 minutes. Preparation action begins about 30 minutes after its adoption and lasts for 6 hours.
Indications
Groprinosin should be taken in the following cases:
- under the following infectious diseases: influenza, measles, Adenoviral and rhinovirus infection , Parainfluenza, acute respiratory infections, bronchitis, viral, mumps epidemic ;
- in diseases provoked by virus Herpes simplex type I or Type II ( herpes skin face, lips, hands, oral mucosa, ophthalmoherpes ) Virus Varicella zoster ;
- chronic recurrent occurrence infections of the genitourinary system and respiratory in patients who have a weakened immune system ( Chlamydia and etc.).
Contraindications
Groprinosin has the following contraindications:
- hypersensitivity to one of the components of the formulation;
- Artim ;
- urolithiasis disease ;
- gout ;
- chronic renal failure ;
- pregnancy and lactation ;
- children up to 3 years.
With the utmost care medicine can be used in conjunction with xanthine oxidase inhibitors . zidovudine . diuretics As well as at acute liver failure .
Side effects
The use of this medication may cause some side effects:
- fatigue, dizziness, . headache Sometimes - insomnia . nervousness . drowsiness ;
- rash . itch ;
- exacerbation gout . joint pain ;
- nausea . decreased appetite . vomiting Sometimes - constipation . diarrhea ;
- allergic reactions ;
- polyuria ;
- increase in uric acid concentration in urine and blood.
Instructions for use Groprinosina (method and dosage)
The drug is taken by mouth, after food, drink it must be a small amount of water 3-4 times a day through an equal amount of time (6-8 h.).
Instructions for adults : 6-8 tablets consume 3-4 times a day.
Instructions Groprinosinu for children from 3 to 12: 50 by use of 3-4 mg / kg per day.
In heavy infections dosage can be increased. For adults the maximum dose day 3-4 4-6, in receptions, for children - 50 mg / kg per day.
In acute diseases The course lasts 5 to 14 days, the course should be continued for another 2-3 days for prevention and after the disappearance of symptoms.
With recurrent chronic diseases treatment session can be 5-10 days with possible intervals of 8 days. The total duration of treatment is 30 days, and you can reduce the dose to 500 mg per day.
In the treatment of infections caused by herpes virus For children and adults held a course of treatment lasting 5-10 days until symptoms disappear. To reduce the possibility of recurrence, additional courses are recommended 1 tablet twice a day for 30 days.
Groprinosin 500 children up to 3 years is absolutely contraindicated. For older people daily dose is the same as the middle-aged people. When treating Groprinosinom people suffering kidney and hepatic insufficiency It should be every 14 days to carry out the procedure for checking and control of entry level of uric acid in serum and urine. With longer treatment medication every 4 weeks is recommended to monitor liver enzymes.
Overdose
In studies overdoses were observed. Overdose can lead to increased levels uric acid concentrations in blood serum and urine . In this case advised symptomatic therapy and gastric lavage .
Cooperation
The immunostimulatory effect of the drug can be reduced by simultaneous use with antidepressants . When combined with the use of zidovudine It may require correction value of the dose. With increased caution should be used in conjunction with Groprinosin inhibitors ksantinoksdazy or loop diuretics .
Terms of sale
In pharmacies, the drug is sold by prescription.
Storage conditions
Tablets be stored at a temperature of not more than 30 ° C out of reach of children.
Shelf life
Shelf life is 3 years.
Analogs Groprinosina
Kagocel
Izoprinozin
Allokin Alpha
Panavir
Ingavirin
Amizon
Anaferon
Arbidol
The analog of the drug is AND zoprinozin . The price of the analogue varies from 70 to 400 UAH. depending on the number of tablets in the package. Analogues cheaper Groprinosina have not.
What better Isoprinosine or Groprinosin?
As part Groprinosina the same active substance as in izoprinozin, but it contains other auxiliary substances that soften the impact Groprinosina on the body, so it can be used, and the elderly.
Groprinosin and alcohol
Simultaneous use of Groprinosina with alcohol may adversely affect the state of the patient's liver. If necessary, take a break Magee taking drugs and alcohol for at least 2 hours to soften the impact on the body.
Reviews Groprinosine
Among the buyers of most of the notes that the drugs are effective, but many are seen side effects such as nausea and loss of appetite . Often you can find reviews about how to take children up to 3 years, although the manual is forbidden.
It's pretty gentle medicine, so the appointment Groprinosina children, mostly positive reviews. If strict compliance with the established dose of the drug for children, responses boil down to the fact that there is a positive effect and minimum side effects manifest.
Regarding efficiency at Groprinosina HPV , Positive feedback, after a course of the drug in many patients reduced the level of HPV in a smear.
Price Groprinosin where to buy
The average price for a tablet Groprinosin 50 pcs. in the package in Moscow is 1000 rubles.
Price in Ukraine tablet of 20 pieces in the package an average of 98 UAH, with 50 units - 260 UAH.
In Belarus, in particular in Minsk, the price depending on the total number of tablets in the package varies from 70 000 to 176 000 rubles.
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