Description overdue on
- Latin name: Alfa Normix
- ATC code: A07AA11
- Active substance: Rifaximin (Rifaximin)
- Manufacturer: SpA Alfa Wassermann, Italy
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
The composition of one tablet 200 mg of active substance ( rifaximin ) + Additional agent (sodium carboxymethyl starch, microcrystalline cellulose, glycerol palmitostearate, colloidal silica, talc, hypromellose, E172, titanium dioxide, edetate disodium, propylene glycol).
In 5 ml of pre-prepared suspension of 100 mg of the drug falls rifaximin + Additional ingredients (carmellose sodium, kaolin, sodium benzoate, flavor "wild cherry", microcrystalline cellulose, pectin, sodium saccharin, sucrose).
Product form
The drug release in the form of convex circular pink coated tablets. 12 pieces in blister, one or three blisters in the package.
Also means are sold in the form of pellets for the preparation of the orange-colored suspension. The suspension has a characteristic smell and taste of cherries. The bottle of dark glass of 5 ml, the kit includes a measuring cup.
Pharmacological action
The spectrum of action antibiotic
Pharmacodynamics and pharmacokinetics
The preparation contains the active substance in the alpha form. It is an antibiotic belonging to the group rifampicin . rifaximin It inhibits the synthesis process RNA and proteins in bacterial cells. This process is irreversible, the bacterium dies.
Gram-positive and Gram negative bacteria .
In the intestine, the antibiotic is not absorbed and does not enter the systemic circulation, therefore substance acts only on the intestinal microflora and significantly reduces the level of pathogenic intestinal bacterial flora. When the antibiotic rarely causes serious adverse reactions.
- quantity ammonia and other waste products of bacteria;
- number of bacteria present in diverticula of the colon Thus, reducing inflammation around diverticular sac Eliminating the symptoms and reducing the risk of complications during diverticular disease ;
- proliferation of microorganisms (if it is increased because of the syndrome of excessive growth of bacteria in the intestine);
- specific antigenic stimulus Which may initiate and maintain the chronic inflammation in the intestine;
- colorectal operations.
It absorbed through the gastric mucosa less than one percent of the antibiotic. In the blood after administration is not detected (sometimes present in small amounts). If the maximum daily dose of 0, 8 g, reaches its peak concentration in the intestine for three hours. Once detected in the urine, but in an amount less than one percent.
Indications
Antibiotics administered for treatment of infections that are sensitive to its effects, namely:
- syndrome of excessive growth of bacteria in the gut;
- divertikuleznoe disease of the colon ;
- traveler's diarrhea ;
- ZHTK ;
- hepatic encephalopathy ;
- inflammatory bowel disease (Chronicle);
- prevention of complications after surgery in colorectal .
Contraindications
Contraindications to receive the tablets are:
- all types bowel obstruction ;
- intestinal ulcers ;
- allergy components for medication.
The suspension does not designate the presence of an antibiotic allergy or components in the composition.
Side effects
Of those that were observed during the study drug, most are symptoms of opportunistic diseases: improving Blood Pressure . dizziness , Palpitations, headache Distortion or loss of taste, breathlessness , Rash, cold sweat, fever . diarrhea . heartburn . angioedema .
Most likely the occurrence of reactions from the gastrointestinal tract: nausea . epigastric pain . vomiting . The most common reactions of this kind are by themselves some time after the beginning of reception.
Alpha Normiks, instructions for use (method and dosage)
Alpha Normiks tablets
The dosage and duration of administration is determined by the attending physician.
Persons under 12 years of age shall appoint one tablet every 8 hours or 2 tablets every 12 hours. Treatment should not be longer than 7 days.
The course may be repeated no earlier than a month.
To prepare the suspension in a vial was added water (up to the first mark), shaken well and water is added to the next mark. The required amount of finished slurry is metered by a measuring cup.
Already prepared solution can be used within a week (with the condition of storage at room temperature). Before use, the suspension should be shaken.
For children older than 12 years and adult dose per day is 600-1200 mg of the antibiotic, which corresponds to the reception of 10-20 ml 2-3 times a day.
At the age of 6 to 12 years of daily dose - 400-800 mg. Take 2 ml of suspension 10-20 times a day.
For children 2-6 years of daily dose - 200-600 mg. Assign 5-10 ml 2-3 times a day.
The course does not exceed 7 days. Before taking you should consult with your doctor.
Overdose
When you receive less than 2400 mg daily overdose is impossible.
In the case of receiving doses greatly exceeding the recommended should wash out the stomach, produce symptomatic therapy.
Cooperation
Interaction with other means unlikely due to the fact that the drug does not get into the systemic circulation.
Terms of sale
It requires a prescription.
Storage conditions
Tablets and granules are stored in a cool place out of reach of small children.
Shelf life
3 years. After cooking, the suspension can be stored in a refrigerator for 7 days.
Cautions
Very rarely, if damaged intestinal mucosa, it may be received about one percent of the antibiotic into the systemic circulation. In this regard, perhaps Urine staining reddish-orange .
Analogs of Alpha Normiks
Pimafucin
Nystatin
Alpha Normiks analogues are: Rifaximin, Pimafucin, Nystatin .
Reviews of Alpha Normiks
The drug is good. Reviews of Alpha Normiks mostly positive. The drug helps to cope not only with chronic bowel diseases, but also effective as an emergency vehicle. Many people forget that after receiving such strong antibiotics should drink a course probiotics to restore normal microflora in the intestine .
It is not necessary to self-medicate, medication must be taken under control and after consultation with the doctor.
Price Alpha Normiks where to buy
Buy pills can be priced at 600 rubles per 12 pieces.
Price Alpha Normiks 36 tablets - 1400 rubles.
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