Omaron

Description overdue on 10/22/2014

• Latin name: Omaron
• ATC code: N06BX
• Active substance: Piracetam + Cinnarizine (Piracetam + Cinnarizine)
• Manufacturer: Nizhpharm OAO, Russia

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Omarona
• Contraindications
• Side effects
• Tablets Omaron, instructions for use
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Synonyms
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

1 tablet contains 400 mg Omarona Pyracetam   and 25 mg Cinnarizinum   - Active ingredients.

Auxiliary ingredients:

• 0, 0235 g - lactose monohydrate;
• 0, 0468 g - pentahydrate magnesium hydroxycarbonate;
• 0, 0039 g - povidone K30;
• 0, 0052 - Aerosil A-380;
• 0, 0052 g - monohydrate, calcium stearate;
• 0, 0104 g of - crospovidone.

Product form

Tablets ploskotsilindricheskoy form 30, 60 or 90 units in a single package.

Pharmacological action

Nootropic, antihypoxia, vasodilator.

Pharmacodynamics and pharmacokinetics

Omaron is a combined drug having a antihypoxic, vasodilator and nootropic action .

Pyracetam One of the active substances Omarona enhances the energy and protein metabolism, accelerates cell glucose utilization and improves their resistance to   hypoxia Thus activating the brain metabolic processes. In the central nervous system positively affects the interneuronal transmission, in the ischemic area improves the system of regional blood flow.

The second active ingredient - Cinnarizinum   It is a selective blocker of slow calcium channels inhibits the influx of calcium ions into cells, reducing their concentration in the depot plasmolemma, reduces smooth muscle tone of the arterioles, inhibits their response to biogenic vasoconstrictor (norepinephrine, epinephrine, dopamine, vasopressin, angiotensin).

Exhibits a vasodilatory effect (particularly with respect to the vessels of the brain), increases the effectiveness of piracetam antihypoxic, while not significantly affecting blood pressure. It has a mild antihistamine activity, reduces the excitability of the vestibular apparatus, lowers the tone of the sympathetic nervous system, as well as beneficial effects on elasticity erythrocyte   membranes, their susceptibility to deformation improves blood viscosity.

Following oral administration of piracetam completely and quickly absorbed from the gastrointestinal tract, reaching a Cmax in the plasma for 2-6 hours, and for 2-8 hours in the CSF has 100% bioavailability.

The drug does not bind to plasma proteins is distributed in almost all tissues and organs of the body, it passes the placental barrier. In the cortex of the brain selectively accumulates mainly in the occipital, parietal, and frontal lobes, basal ganglia and cerebellum.

Piracetam can not be metabolism and after about 30 hours it is excreted in urine (95%).

Cinnarizine plasma Cmax reached in 1-4 hours. The plasma protein binds to 91%.

The metabolism of cinnarizine goes active and full, with a half-life, which is 4 hours.

One-third of the metabolites excreted by the kidney, bowel rest.

Indications Omarona

Indications for use are Omarona CNS diseases, which are accompanied by intellectual and mental disorders:

• Treatment of posttraumatic or postintoksikatsionnoy encephalopathy ;
• Therapy circulatory failure of the brain (including the atherosclerosis   its vessels, as well as in the recovery period after suffering a hemorrhagic and ischemic stroke );
• depression ;
• mental retardation in children;
• vestibular disorders;
• psycho-organic syndrome, especially with signs adinamii   and asthenia ;
• Meniere's syndrome ;
• prophylaxis of seizures migraine , and kinetoses , Adult patients and pediatric.

Contraindications

• Customizing hypersensitivity   to piracetam, cinnarizine or other ingredients of the drug Omaron;
• lactase deficiency , Lactose intolerance, glucose-galactose syndrome malabsorption (due to the content of lactose in a preparation);
• severe liver disease, and kidney (creatinine clearance (CC) is less than 20 ml / min);
• Parkinsonism ;
• hemorrhagic stroke ;
• Huntington's syndrome;
• psychomotor agitation;
• period Lactation   and period pregnancy ;
• under 5 years old.

Carefully:

• Chronic renal failure (creatinine clearance - 20-80 ml / min);
• diseases of the liver and / or kidney problems (mild and moderate severity);
• porphyria;
• increased intraocular pressure;
• violation of hemostasis;
• heavy bleeding;
• surgical interventions on extensive areas of the body;
• epilepsy ;
• hyperthyroidism ;
• predisposition to the reactions of neurotic character;
• atherosclerosis blood vessels of the brain.

Side effects

Peripheral and central nervous system:

• irritability;
• motor disinhibition;
• drowsiness ;
• asthenia;
• depression ;
• headache .

In rare cases:

• dizziness ;
• exacerbation epilepsy ;
• ataxia ;
• extrapyramidal disorders;
• unbalance;
• tremor ;
• reduction of concentration;
• excitement;
• improving sexuality;
• insomnia ;
• anxiety;
• hallucinations.

Cardiovascular system:

• an increase or decrease in blood pressure.

Digestive system:

• sensation of dryness in the oral cavity;
• dyspepsia.

In rare cases:

• nausea;
• diarrhea ;
• stomach ache;
• vomiting ;
• cholestatic jaundice.

Skin (in rare cases):

• itch ;
• dermatitis ;
• rashes on the skin .

Allergic symptoms:

• angioedema .

Others:

• increased sweating;
• weight gain.

In rare cases:

• Lichen planus;
• lupus-like syndrome.

Tablets Omaron, instructions for use

Instructions for use Omarona recommends taking pills orally (inside) during the reception look or immediately after a meal.

Adult patients are usually prescribed 1-2 tablets three times a day Omarona, for 30-90 days, depending on the pathology and its severity. The course of therapy can be carried out 2-3 times a year.

Kids after reaching 5 years of age is recommended 1 or 2 times daily 1-2 tablets. The maximum allowable time of treatment - 3 months.

In order to prevent kinetoses adult patients take 1 tablet, children after 5 years - half a tablet. Admission Omarona performed 30 minutes before the intended stay and may be repeated after 6-8 hours.

If renal failure (creatinine clearance - 20-80 ml / min) is possible to use one pill 2 times a day.

Overdose

In overdose possible Omaronom vomiting, impaired consciousness, low blood pressure, extrapyramidal symptoms. When receiving a dose of piracetam 75 g or more were observed abdominal pain and bloody diarrhea.

Since there is no specific antidote, carry out gastric lavage and appoint chelators . Later, if needed, the recommended treatment and symptomatic.

The efficiency of a hemodialysis equals 50-60% (with respect to piracetam).

Cooperation

When combined with ethanol, CNS depressants, antihypertensives and nootropic drugs, there has been increasing their sedative effect.

Vasodilating drugs enhance the effect Omarona.

Omaron improves the tolerability of tricyclic antidepressants and antipsychotics.

Piracetam may enhance the central effects of drugs based on thyroid hormones (sleep disturbances, tremors, irritability, anxiety).

When concomitantly with oral anticoagulants, Omaron can increase their effect.

Terms of sale

Prescription.

Storage conditions

The temperature is not above 25 ° C.

Shelf life

36 months.

Cautions

Chronic administration Omarona recommended to check your liver and kidneys (particularly in patients with CHF).

In the course of therapy in patients with arterial hypotension was observed more pronounced decrease in blood pressure.

Possible error in the results of skin allergy tests and doping tests, in this connection, for 4 days prior to the proposed study Omaron should be abolished.

Analogs

Match code ATC 4th level:

• Cere
• Noben
• Cortexin
• Pantogam
• Pantogam Active
• Tiotsetam
• Noopept
• Kogitum
• Encephabol
• Tserakson
• Pikamilon
• Phenotropil
• Nootropil
• Vinpocetine
• Aminalon
• Fezam
• Pyracetam
• Cavinton
• Semaks

Analogs Omarona presented fairly extensive list of drugs with similar action by the well-known of which are:

• Vinpocetine ;
• Glycine ;
• Cavinton ;
• Lutset ;
• Nootropil ;
• Tiotsetam ;
• Pantogam   etc.

Synonyms

• Fezam ;
• Kombitropil ;
• Piratsezin ;
• Nooke .

Omaron or Fezam that better?

According to specialists, uses in his practice as a Omaron   and Fezam , These drugs are virtually identical and are used for the same diseases have the same side effects, indications and contraindications, as well as have an equal efficiency.

All this is due to the fact that these drugs in their composition, have the same set of active substances (piracetam and cinnarizine), i.e., are essentially synonymous. It is worth noting that the price Fezam somewhat more compared to the price Omarona.

Babies

Omaron drug is contraindicated in patients under 5 years of age.

With alcohol

During treatment Omaronom recommend renounce the use of alcohol.

During pregnancy (and lactation)

The drug Omaron not use during lactation and pregnancy.

Reviews Omarone

For the treatment of certain diseases of the central nervous system, accompanied by intellectual and memory impairment, widely used combination nootropic drugs, among them one of the most important places of the drug takes Omaron. Reviews of doctors about this medication overwhelmingly positive. Experts note the high efficiency Omarona both during treatment and in appointing him to prevent disease states such as migraine syndrome and motion sickness.

It must be remembered that the choice of a nootropic drug requires a personal approach to each patient, so even if you have not approached Omaron, experienced doctor without any problems will select its analogue.

Price Omarona where to buy

In Russia Omarona pills you can buy, depending on the region of:

• №30 - 100 rubles;
• №60 - 150 rubles;
• №90 - 200 rubles.

Price Omarona in Ukraine is:

• №30 - 35 hryvnia;
• №60 - 50 hryvnia;
• №90 - 80 hryvnia.

Get the best price and buy