Description overdue on 09/26/2014
- Latin name: Glevo
- ATC code: J01MA12
- Active substance: Levofloxacin (Levofloxacin)
- Manufacturer: Glenmark Pharmaceuticals Ltd., India
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Glewe, instructions for use (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
Glewe Tablets contain 250 mg or 500 mg levofloxacin That is presented in the form of a hemihydrate.
Auxiliaries are the Avicel pH 101, MCC, crospovidone, starch, magnesium stearate, povidone.
The composition of the shell of the tablet Glewe 500 mg : Macrogol, talc, iron oxide red dye, hypromellose, titanium dioxide, dibutyl phthalate.
The composition of the shell of the tablet Glewe 250 mg : Macrogol, talc, dye iron oxide red, yellow, hypromellose, titanium dioxide, dibutyl phthalate.
Product form
Tablets Film-coated red (250 mg) or light-orange (500 mg). 250 mg tablets have a round biconvex shape, with one side of the band has a fault, the surface is smooth. Tablets 500 mg oval, biconcave, on the one hand as well strip fault, have a rough surface.
Available in 5 pieces. in a blister in a cardboard box is 1 or 5 blisters.
Pharmacological action
Glewe preparation is a broad spectrum bactericide, having antimicrobial effects .
Pharmacodynamics and pharmacokinetics
The active ingredient of the drug is an antibiotic levofloxacin Belonging to the group ftorhinolinov. It promotes the inhibition of DNA gyrase poison microbes and bacteria, disrupting the synthesis of a protein, whereby the bacteria are killed. Glewe effective in the treatment of infectious diseases caused by both gram-positive and gram-negative microorganisms, including bacteria that are resistant to cephalosporins, penicillins and aminoglycosides.
It has a wide range of actions: Escherichia coli, Proteus mirabilis, Providencia rettgeri et stuartii, Staphylococcus aureus, Enterobacter agglomerans, Acinetobacter calcoaceticus, Streptococcus pyogenes, Clostridium perfringens, Staphylococcus epidermidis, Staphylococcus epidermidis, Acinetobacter baumannii, Klebsiella oxytoca, Enterococcus faecalis, Proteus vulgaris, Pseudomonas aeruginosa, Streptococcus agalactiae, Bordetella -pertussis, Viridans group streptococci, Streptococcus pneumoniae, Morganella morganii, Enterobacter cloacae, Serratia marcescens, Mycoplasma pneumoniae, Citrobacter diversus, Enterobacter aerogenes, Citrobacter freundii, Enterobacter sakazakii, Legionella pneumopnia, Haemophilus influenzae, Acinetobacter anitratus, Moraxella catarrhalis, Chlamydophila pneumoniae, Haemophilus parainfluenzae, Pseudomonas fluorescens .
The spirochetes are insensitive to the action levofloxacin .
Absorbed by ingestion quickly and almost completely. For speed and completeness of the suction meal almost no effect. Bioavailability is 99%. Maximum concentration in the blood observed after 1-2 hours.
Associated with the plasma protein by about 30-40%. The high level of penetration in tissues and organs (bronchial mucosa, alveolar macrophages, organs of the urogenital system, lungs, polymorphonuclear leukocytes, sputum).
A small portion of the substance is oxidized or deacetylated in the liver.
Of total clearance renal clearance is about 70%. The half-life takes an average of 6-8 hours. Derived mainly from the body using the kidneys. Excreted in the urine of approximately 70% of the dose per day (unmodified), 87% of the dose - for two days, less than 4% is excreted within three days from the faeces.
Indications
Glewe antibiotic indicated in the treatment of infectious and inflammatory diseases caused by microorganisms sensitive to the drug:
- lower respiratory tract disease (including outpatient pneumonia and exacerbation chronic bronchitis );
- diseases of the genital organs (including prostatitis );
- ENT diseases (including acute sinusitis );
- diseases of the skin and soft tissues ( furunculosis . abscess , Festering atheroma );
- kidney and urinary tract (including acute pyelonephritis ).
In combination with other drugs that act on the anaerobic flora, an antibiotic used to treat intra-abdominal infections.
Contraindications
Glewe The drug is not recommended in the following cases:
- pregnancy;
- epilepsy ;
- age 18 years;
- tendon damage (while held earlier treatment quinolones);
- breast-feeding;
- sensitivity levofloxacin .
Precautions medication prescribed to patients in the elderly (as it increases the likelihood of decreased kidney function) and in the presence deficiency of glucose-6-phosphate dehydrogenase .
Side effects
During therapy, the drug may develop the following adverse effects:
- fungal infections ;
- eosinophilia . hemolytic anemia . leukopenia . neutropenia . pancytopenia . thrombocytopenia . agranulocytosis ;
- angioedema Hypersensitivity reactions (including anaphylactic or anaphylactoid shock ), In some cases, anaphylactic and anaphylactoid reactions may occur after the first dose;
- hypoglycemia . hypoglycemic coma . anorexia . hyperglycemia ;
- depression , Abnormal dreams, anxiety, nervousness, insomnia , Nightmares, agitation , Psychotic disorder (including paranoia and hallucinations ), Confusion, anxiety, self-destructive behavior, including suicidal thoughts or actions direction;
- dyskinesia . drowsiness , Benign intracranial hypertension, tremor . dysgeusia . ageusia . parosmiya . anosmia , Convulsions, extrapyramidal disorder, sensory or sensorimotor peripheral neuropathy, impaired coordination of movements;
- blurred, blurred vision, temporary loss of vision;
- tinnitus, hearing loss or violation, vertigo ;
- palpitations, ventricular arrhythmia . tachycardia , Ventricular tachycardia (may lead to cardiac arrest);
- leykotsitoklastichny vasculitis . hypotension ;
- breathlessness . hypersensitivity pneumonitis . bronchospasm ;
- vomiting, dyspepsia . diarrhea , Abdominal pain, nausea, bloating, diarrhea gemoragichnaya, which may be indicative of enterocolitis , abdominal pain;
- hepatitis, hepatic enzymes increase performance, increased blood bilirubin, jaundice , Liver injury, including cases of hepatic failure;
- itching, increased sensitivity to the sun and ultraviolet rays, photosensitivity, rash, toxic epidermal necrolysis . hyperhidrosis . Stevens-Johnson syndrome , Mucocutaneous reactions may occur after the first dosing;
- tendon damage (inflammation) myalgia . arthritis . arthralgia , Rupture of ligaments, muscles, tendons, muscle weakness;
- increased rates of creatine in the blood, kidney failure;
- fever, attacks porphyria . asthenia , Pain in the back, legs, chest.
Glewe, instructions for use (method and dosage)
The tablets are taken orally, washed down with 1 glass of water before taking the tablet do not share or crushed. Should take regardless of the meal. The size of the dose and duration of drug administration set specialist. After the disappearance of symptoms it is recommended to take the drug for 2-3 days.
Instructions for use 500 mg Glewe
Accepted at sinusitis . intra-abdominal infections and prostatitis one tablet per day. Thus in the treatment of intra-abdominal infections in parallel appointed other antimicrobials. Duration of typically 7-10 days.
Patients with septicemia , Infectious diseases of soft tissues . skin and urinary tract And nebolnichnoy pneumonia appointed one pill 2 times per day. The course of treatment lasts up to two weeks.
Instructions for use 250 mg Glewe
In uncomplicated urinary tract infections advised to take one tablet every day for 3 days.
During exacerbation chronic bronchitis prescribed 1-2 tablets per day. Duration of reception is from 7 to 10 days.
Additional doses are required after hemodialysis and CAPD.
No dose adjustment is required in patients with impaired hepatic function, as the substance is metabolized in the liver to a small extent.
The dosage regimen for elderly patients remains unchanged.
If the drug was missing, you should immediately take the pill, regardless of the time of the next appointment. Then continue taking the drug at the statutory scheme.
Overdose
When high doses of the drug may develop nausea, shock syndrome, dizziness, impairment of consciousness, seizures.
No antidote to the drug. Symptomatic treatment and measures to maintain the cardiovascular system. Treatment is carried out in a hospital environment, and the need to control the ECG. Hemodialysis is not effective in case of overdose. If after receiving the high dose was not more than an hour, carry out gastric lavage, and then assigned to receive enterosorbents.
Cooperation
At simultaneous reception levofloxacin and cyclosporine increases the half-life of the latter.
Efficacy is reduced at the same time taking a sucralfate , Means oppressive intestinal motility, iron salts, aluminum and magnesium products. It should be between the administration of these funds to make a break of at least 2:00.
Seizure may increase the parallel application levofloxacin and theophylline or NSAIDs .
Increases the possibility of tendon rupture while taking Glewe and GCS .
Excretion Levofloxacin slows when concomitantly with drugs that block tubular secretion, and tsimedina .
The development of hyper- and hypoglycemia possible using both levofloxacin and hypoglycemic agents. It is necessary to strictly control glucose levels.
Terms of sale
Glewe released from pharmacies by prescription.
Storage conditions
The drug should be stored in a dark, dry place at temperatures not exceeding 25 ° C.
Shelf life
Shelf life Glewe - 24 months.
Cautions
Despite the fact that the solubility of levofloxacin is higher than the other quinolones, patients are recommended to conduct hydration of the body .
Avoid direct exposure to sun and UV rays to prevent skin damage.
Cancel treatment and therapy should immediately conduct when evidence tendinitis .
Development of possible seizures in patients undergoing stroke or severe brain injury .
Be careful when driving because of the risk of side effects from the medication.
Analogs Glewe
Floratsid
Avelox
Fleksid
Levolet P
Norbaktin
Tsiprinol
Ofloksin
TSifran
Tavanic
Nolitsin
Ofloxacin
Analogs of the drug: Zolev . Lebel . Levobaks . Levobakt . Levokilz . Levoksa . Levoksimed . Levolet . Levomak . Levostad . Levotor . Levofloks . Levofloxacin . Toksof . Taygeron . Fleksid . Floksium . These drugs have a similar structure and pharmacological effect.
Reviews Glewe
Average rating of preparation 250 and 500 mg for the evaluation of patients, it takes - 3, 5 points. Reviews Glewe consumers can be divided into two groups: some are satisfied with the action of the drug, as it helped to cope with the disease with minimal side effects, the drug is often considered ineffective, as evident when taking adverse action.
Reviews of doctors are reduced to what Glewe - strong antibiotic, which can be taken only after consultation with a specialist. Also it notes that the parallel is recommended to take probiotics Not to disturb the intestinal microflora in the treatment.
Price Glewe
In Moscow, the price of 250 mg of the antibiotic Glewe leaves about 170 rubles.
Price Glewe 500 mg 5 tablets - from 170-214 rubles., 10 tablets - 438-510 rub., 25 tablets - 475-571 rub.
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