Description overdue on 21/10/2014
- Latin name: Zopiclone
- ATC code: N05CF01
- Active substance: Zopiclone (Zopiclone)
- Manufacturer: New Farm Inc. / Biotec MFPDK (Canada)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use of zopiclone (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Synonyms
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
In zopiclone tablet contains 7, 5 milligrams of the same name of the active drug compound. In addition, such ancillary components as: microcrystalline cellulose, lactose monohydrate, potato starch, colloidal anhydrous silica, magnesium stearate , and talc, aerosil and povidone .
Product form
This drug comes in tablet form, which is applied on top of a special envelope and powder, packaged in special bags sachets.
Pharmacological action
The medicine refers to sedatives and opiates, within the group pirrolopirazinamidov .
Pharmacodynamics and pharmacokinetics
As a Zopiclone hypnotic derivative tsiklopirrolona, preparation is effective agonists so-called benzodiazepine receptors . This medication is different pronounced anxiolytic, and sedation . In addition, HP released its amnesic, anticonvulsant and muscle-relaxing properties.
Due to the chemical characteristics of the drug included in the drug zopiclone , Is amplified GABA-ergieskih processes in the brain human, thereby increasing the threshold of sensitivity to neurotransmitter GABA-receptors due to interaction with the active components benzodiazepine receptors. When receiving the drug reduced the number of awakenings during the night.
In addition, the drug has beneficial effects on the process of falling asleep and increases the duration of sleep. It is worth noting that the drug has no negative impact on the very structure of sleep, that is, It does not change its stage, for example, reduces the duration of REM sleep, and so on. The drug dissolves quickly enough in stomach and reaches its maximum concentration already after a few hours after its administration.
The drug is easily overcome gistogematicalkie barriers and evenly distributed in the tissues and organs of the human body, including the brain. If re-treatment Zopiclone cumulation not shown. Within half an hour after using the drug comes deep sleep, the duration of which is a maximum of eight hours.
It should be noted that while taking zopiclone and medicaments containing composition theophylline , Patients with asthma significantly decreases the duration and furthermore the intensity of asthmatic attacks in early morning hours.
Indications
Typically, the drug is prescribed in the following sleep disorders:
- difficulty falling asleep;
- permanent night or early morning awakening;
- insomnia, including chronic, intermittent or situational kinds of ailments;
- restless sleep;
- sleep disturbances associated with different types of psychiatric disorders.
Contraindications
Absolute contraindications include:
- hypersensitivity;
- pregnancy;
- respiratory failure;
- age 18 years;
- lactation.
In addition, with extreme caution must use this drug patients liver failure, at sleep apnea syndrome, at glucose and galactose malabsorption , In congenital galactosemia At myasthenia And when lactase deficiency .
Side effects
With the correct dosage of the drug zopiclone side effects usually do not appear. However, significant excess doses may experience the following ailments:
- amnesia;
- behavioral disorders;
- aggressiveness;
- Sleepwalking;
- confusion or altered consciousness;
- rebound insomnia;
- psychological or physiological dependence;
- speech disorders;
- depression;
- loss of coordination;
- dizziness;
- ataxia;
- hallucinations;
- euphoria;
- headache;
- decreased sex drive;
- skin rash;
- diplopia;
- hypotension;
- angioedema;
- urticaria and other allergy;
- asthenia;
- dispersion;
- hypotension;
- vomiting;
- anorexia;
- diarrhea;
- weight reduction.
It is worth noting that in overdose patients experience dry mouth and a bitter taste . In some cases, it may be increased liver enzymes .
Instructions for use of zopiclone (method and dosage)
Therapeutic (average) dose according to the instruction on Zopiclone (zopiclone) is 7, 5 mg., Corresponding to a single tablet. The drug is taken just before bedtime. In severe forms insomnia dosage can be increased twice. However, patients in the elderly and people suffering from disorders liver function It should not take more than 3, 75 mg. Zopiclone per day.
Overdose
Drug overdose occurs when exceeding the average recommended therapeutic dose of the drug and can threaten the patient's life. As a rule, in the event of an overdose occurs oppression CNS (central nervous system). Symptoms of overdose may be considered sluggish condition of the patient , and drowsiness, confusion, respiratory depression, ataxia, hypotension and hypotension.
If it has been less than one hour after administration of the drug, it can cause the patient vomiting . In other cases, you should immediately conduct gastric lavage While paying special attention to the protection Respiratory . In order to reduce absorption contained in the drug zopiclone patients discharged Activated carbon .
Cooperation
Zopiclone is forbidden to take simultaneously with alcohol and alcohol-containing medicines. In addition, the drug reduces the effectiveness Trimipramina and a dampening effect on the nervous system drugs with anxiolytic, antidepressant, antihistamine, a sedative, anticonvulsant , and antipsihotropnym effect.
Terms of sale
According to medical prescription.
Storage conditions
Zopiclone is included in the list of drugs B, so the drug should be stored in a dry place, out of reach of children.
Shelf life
2 years.
Cautions
The risk of addiction can develop when too prolonged use of the drug. During the period of use of zopiclone it is forbidden to drink alcohol. The following day, after using this medication should refrain from driving or working with potentially dangerous machinery and apparatus.
Analogs of zopiclone
Imovan
Among the analogues of zopiclone are the following drugs:
- Imovan;
- Relakson;
- Zopiclone 7, 5 - SL;
- Somnol;
- Piklodorm;
- Thorson.
Synonyms zopiclone
Zopiclone
Babies
Not recommended for patients under the age of 18 years.
During pregnancy (and lactation)
The drug is forbidden to take in the period Lactation or during pregnancy .
Reviews of Zopiclone
On the Internet you can find a wide variety of reviews of zopiclone. Many patients taking this hypnotic , Positive about its effectiveness. However, the negative aspects of the drug people often include an impressive list of side effects and note that Zopiclone is not suitable for long-term treatment of sleep disorders.
Price zopiclone, where to buy
The average price of Zopiclone (zopiclone) varies from region. For example, buy Zopiclone in Moscow can be as low as 550 to 1000 rubles.
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