Description overdue on 08/18/2014
- Latin name: Trittico
- ATC code: N06AX05
- Active substance: Trazodone (Trazodone)
- Manufacturer: Aziende Chimiche Riunite ANGELINI FRANCESCO ACRAF, Italy
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on Trittiko
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One tablet contains 75 or 150 mg trazodone hydrochloride .
Other ingredients: carnauba wax, sucrose, polyvinylpyrrolidone, magnesium stearate .
Product form
Trittico Tablets Controlled release is typically a white or white-yellow, oval-shaped, with two parallel strips on both poles.
Form release tablet dosage of 75 mg:
- 15 tablets in a blister, 2 blisters in such paper packaging;
- 30 tablets in a blister, 1 blister in a paper box.
Method of production for tablets 150 mg:
- 10 tablets in a blister, 2 or 6 of blisters in the paper packaging;
- 20 tablets in a blister, 1 or 3 of the blister package in the paper.
Pharmacological action
The drug has Trittico antidepressant action.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
Trazodone - derivative triazolopyridine It has antidepressant and weak sedative and anxiolytic effects. It has no effect on the MAO , Unlike tricyclic antidepressants Inhibiting MAO-inhibitors .
Quick action on mental (irritability, insomnia , Affective tension, fear) and somatic anxiety symptoms (headache, heartbeat , Muscle aches, sweating, frequent urination, hyperventilation ).
The drug is also effective for sleep disorders in patients with depression . Increases the duration of sleep, normalizes its physiological structure.
Trazodone has a stabilizing effect on the emotional state, reduces the craving for alcohol in patients with chronic alcoholism It improves mood. Not addictive. It helps strengthen libido and potency .
Trazodone is highly affinity a number of subtypes of serotonin receptor, with which it comes into agonistic or antagonistic interaction, and can cause suppression of the reuptake Serotonin .
Pharmacokinetics
The extent of absorption of the drug from the intestine after taking high. Admission during or after a meal slows the rate of absorption. The maximum concentration of drug in the blood occurs within 2 hours after consuming means.
Penetrates gistogematicalkie barriers, as well as in saliva, bile, breast milk.
Interaction with plasma proteins - 90-95%. The preparation is transformed in the liver. The half-life is 6-9 hours. Excretion through the kidneys (75%) and in bile (20%).
Indications
- Psychogenic depression (including neurotic and reactive depression ).
- Alcohol depression.
- Anxiety and depression.
- Depressions at the expressed painful syndrome.
- Anxiety-depressive states combined with organic lesions of the nervous system ( Alzheimer's disease, dementia, atherosclerosis of brain ).
- Benzodiazepine dependence.
- Fouls libido and potency .
Contraindications
- Allergies Trittiko tablets.
- Lactation.
- Pregnancy.
- Age less than 6 years.
Be wary appoint persons with AV block, ventricular arrhythmia . myocardial infarction, hypertension, hepatic or renal failure As well as persons under the age of 18, due to the risk of suicidal behavior pattern (aggressiveness, suicidal plans, anger).
Side effects
The drug can cause side effects listed below:
- the nervous system - fatigue, dizziness, agitation, headache, myalgia Weakness, paraesthesia, tremor ;
- from the circulatory system and blood formation - orthostatic hypotension, bradycardia, pressure drop, conduction disturbances, arrhythmia ; neutropenia and leukopenia ;
- on the part of the digestive system - nausea, dry mouth, diarrhea ;
- Other - eye irritation, Allergic reaction.
Instructions on Trittiko
Instructions for use Trittiko prescribes use the drug inside, a half hour before or 2 hours after a meal, not chewing and drinking water.
The initial dose Trittico - 50-100 mg once a day at bedtime. After 3 days, the dose can be increased to 150 mg per day. A further increase to 50 mg daily can be performed every 3 days until the desired effect. The daily dose of more than 150 mg divided into 2 doses, a smaller dose is used in the afternoon, and the majority - before going to bed.
The maximum daily dose in stationary conditions - 600 mg, in ambulatory - 450 mg.
Babies aged 6-18 years, initial dose 1, 5 mg per kilogram body weight per day divided into multiple doses. If necessary, the dose was increased to 6 mg per kilogram body weight per day.
Elderly and immunocompromised individuals : An initial dose of 100 mg per day. If necessary, the dose can be increased to 300 mg per day.
Therapy disorders libido : Daily dose of 50 mg.
Treatment Erectile Dysfunction : Monotherapy daily dose - 200 mg, in combination therapy - 50 mg.
Overdose
Symptoms: drowsiness, nausea, hypotension .
Treatment: symptomatic therapy. Specific antidote It is not known.
Cooperation
Trazodone It enhances the action of a number of antihypertensive funds and requires reduction of their doses.
Joint reception with drugs depressing nervous system ( clonidine . metilodopa ), Activates the latter.
Antihistamines drugs and holinoliticheskie means reinforce anticholinergic action trazodone.
Trazodone increases anticholinergic and sedative effects haloperidol . tricyclic antidepressants, loxapine, phenothiazines, maprotiline, pimozidana and t ioksantena .
Joint reception MAO inhibitors It increases the risk of side effects.
Increases concentration phenytoin and Digoxin in blood while using.
Blockers CYP3A4 may lead to increased levels of trazodone in the plasma, increasing the likelihood of side effects.
Carbamazepine reduces the content trazodone in plasma.
Terms of sale
It sold strictly on prescription.
Storage conditions
Keep away from children. Store at temperatures up to 25 degrees.
Shelf life
Three years.
Cautions
Since the vehicle has adrenoliticheskoy activity, while taking may cause bradycardia and reducing the pressure, so patients with conduction disorders, AV block . myocardial infarction care must be taken.
The drug has sedative activity therefore may reduce the reaction rate and attention. During treatment should refrain from activities requiring attention and psychomotor speed reactions.
Analogs
Despres
Gelarium Hypericum
Negrustin
Agomelatine
Azafen
Neyroplant
Analogues of drugs are Velaksin, Venlaksor, Melitor, Mirzaten, Mirtastadin, Prefaksin and others.
Babies
The drug must be used with caution in patients who have not attained the age of 18.
With alcohol
In the period of treatment is recommended to abstain from alcohol-containing beverages.
During pregnancy (and lactation)
The drug is not recommended for lactating and pregnant women.
Reviews Trittiko
Reviews on the forums about Trittiko quite ambiguous and often draw pictures of polar efficacy. Doctors about Trittiko frequently reported side effects, such as complaints of weight gain, high blood pressure and loss of libido.
Price Trittiko
In Russia, the price Trittiko 150 mg №20 is 391-515 rubles, and the Ukraine to buy the drug of the same dosage cost an average of 217 hryvnia.
No comments:
Post a Comment