Cere

Description overdue on 08/12/2014

• Latin name: Cerebrolysin
• ATC code: N06BX
• Active substance: Cere (Cerebrolysin)
• Manufacturer: EVER Neuro Pharma GmbH, Austria

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications Cere
• Contraindications
• Side effects
• Injections Cere: instructions for use
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• For children
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

The structure consists of one milliliter of solution 215, 2 mg concentrate Cere   (peptide drug, derived from porcine brain) and auxiliary components: Caustic Soda (Natrii hydroxidum), water for injection (Aqua pro injectionibus).

Product form

The drug is available in the form of injection with a 5% concentration. The drug enters the pharmacy apmulah   (5 mL Cerebrolysin №5; №10 1 ml; 2 ml №10; №5 10 mL) and sealed with a rubber stopper coated with fluoropolymer volumetric brown glass bottles of 30 or 50 ml.

Please be aware that Cere tablets are not produced .

Pharmacological action

The drug is stimulator neurometabolic processes   (nootropic effect).

Deproteined hydrolyzate pig brain substance stimulates cell differentiation, improves the functional state cells of the nervous system   and activates the mechanisms for the protection and renewal.

Conducted animal experiments have shown that contained in Cerebrolysin biologically active amino acids   and Peptides   have a direct effect on neuronal plasticity of synaptic and that in turn helps to improve higher brain functions .

Pharmacodynamics and pharmacokinetics

The studies using models of cerebral ischemia brain was found that the use of the drug allows:

• reduce heart attack ;
• prevent edema ;
• stabilized microcirculation;
• normalize cognitive and neurological disorders ;
• double the survival rates.

Based on studies using models Alzheimer   led to the following conclusion: in addition to the fact that the drug has a direct effect on Neurons It also increases the number of molecules transports glucose across BBB   (blood-brain barrier), and consequently compensates for critical energy deficit in the organism.

Quantitative analysis encephalograms healthy people and patients diagnosed vascular dementia It showed that treatment with the drug Cere:

• significantly increased neuronal activity   (indicators of activity are dose-dependent);
• objectively improved higher brain functions ;
• increased capacity for self-care and daily tasks (as a consequence - to a lesser extent a patient in need of constant care);

The drug has neurotrophic activity That can significantly slow down, and in some cases stop progression of neurodegenerative processes .

During the experiments, it was revealed that Cerebrolysin not provoke the formation of antibodies or the development of anaphylactic reactions, does not affect the immune system Not stimulated histamine receptors   and it has no effect on hemagglutination of erythrocytes .

As derived from porcine brain proteolytic peptide fraction includes short biologically active peptides Similar or identical to those produced in the body, an accurate drug pharmacokinetic analysis is not possible.

Based on the data of pharmacodynamic drug it was concluded that after single administration neurotrophic activity hydrolyzate plasma   determined over 24 hours.

Cere components have the ability to penetrate through BBB . Preclinical in vivo studies have established an identical effect of the drug on farmakodinamichekoe CNS   when administered in brain ventricles   and upon peripheral administration. These studies are an indirect confirmation of the ability to pass through Cere the cell membranes of the BBB .

Indications Cere

Indications for use Cere are:

• organic lesions, metabolic disorders and degenerative diseases of the National Assembly (in particular disease Altsegeymera );
• Complications developed on the background of suffering stroke ;
• brain injuries and their consequences (the state after neurosurgical operations transferred concussion   and closed head injury);
• mental retardation in children;
• mental disorders Which are accompanied by memory impairment, distraction, etc ..

Contraindications

The drug is contraindicated in case of hypersensitivity to its components, patients suffering from seizures At severe renal impairment .

Side effects

In rare cases, injections may provoke Cere:

• loss of appetite;
• depression;
• apathy;
• general weakness;
• arterial hypo- or hypertension;
• hyperventilation syndrome;
• the appearance of shortness of breath;
• chest pain;
• fatigue;
• the appearance of flu-like symptoms.

Sometimes, the therapeutic effect may be accompanied by agitation - A strong emotional arousal with aggression, confused mind, insomnia.

Too rapid administration of the drug may cause disorders of the nervous system, skin and subcutaneous tissue disorders: dizziness , Appearance tremor . sleepiness .   headache , Feel heat , Increased sweating, itching   and redness of the skin, skin rash (including including the appearance maculopapular rash ) hives .

In a few cases were noted:

• giperchuvstitelnosti reactions or allergic reactions, angioedema . anaphylactic shock , Chills and fever ;
• Generalized seizures ;
• increase in seizure activity;
• a sense of his own heart, tachycardia , Heart pain, arrhythmia   (similar symptoms occurred at too rapid introduction of the drug);
• dyspepsia ;
• nausea   and   vomiting ;
• constipation   or diarrhea ;
• reaction injection site (erythema, burning sensation, local inflammatory reactions);
• pain in the neck and back (in the lower part), of course.

Because the drug is often used to treat elderly people, some of the side effects occurring during the clinical trials may not have a causal relationship with the reception of Cere (most of them occur in these patients not only during treatment with medication).

Some of the identified adverse effects occurred with similar frequency in patients receiving treatment drug, and patients treated with placebo (change in blood pressure, tremors, nausea, weakness, dizziness, shortness of breath, tremor, diarrhea).

Injections Cere: instructions for use

The drug is intended for intravenous and intramuscular administration.

B / Cerebrolysin administered alone at a dose of 5 to 10 ml. If the patient is a dose of 10 to 50 ml (the maximum tolerated dose), the solution is recommended to inject solely by slow intravenous infusion after prior dilution to 100 ml of a standard solution: Ringer's solution, isotonic NaCl solution, 5% glucose solution.

According to the instructions for use of Cere, in diluted form at room temperature and exposed to sunlight on site preparation is physically and chemically stable for days, but from the microbiological point of view, the solution for infusion should be introduced immediately after cooking.

The duration of treatment typically is from 10 to 20 days (assuming daily administration).

It allowed a one-time administration of the maximum dose of the drug (50 ml), but is considered a more effective course application Cere.

Of fundamental importance to achieve the clinical effect of therapy is the use of adequate doses of the drug diagnoses, as well as the right choice of method of administration.

Recommended daily doses:

• 5 to 30 ml - in the degradation of cognitive function, organic pathologies and metabolic brain disorders;
• 10 to 50 ml - to eliminate the effects of a stroke;
• from 10 to 50 ml - for the treatment of brain injury and its effects.

With neurological diseases children   injections are shown from patient administering 1 to 2 ml.

The recommended dose for children aged up to six months - 0, 1 ml per kilogram of body weight. The maximum daily dose for patients in this age group should not exceed 2 ml.

The effectiveness of treatment increases with each repeated course. Treatment is generally continued until until it is a significant improvement in the patient's condition.

During the initial course, the number of administrations could be reduced to 2 or 3 times a week. By the repeated courses should withstand the interval, the duration of which shall not be less than the duration of the preceding treatment.

The manufacturer does not release the drug in tablet form, so look for instructions on the pill Cere meaningless.

Overdose

Cere overdose cases have been identified.

Cooperation

The product is incompatible:

• medicine, the ability to change its pH (5, 0-8, 0);
• lipid-drugs.

Cere allowed to use with balanced solutions amino acids , from Vitamins , Drugs to treat diseases heart and vascular system However contraindicated to mix the medicaments in one bottle for infusion.

Particular attention is recommended to pay potentially possible pharmacological effects, while applying it to monoamine oxidase inhibitors (MAO) or antidepressants .

Terms of sale

To purchase the drug requires a prescription.

Storage conditions

Cere Guide recommends that you keep in the original packaging at a temperature not exceeding 25 degrees Celsius. Keep away from children.

Shelf life

For preparation in ampoules - 5 years, in the vials - 2 years from the date of issue.

Cautions

The drug is prescribed with caution in patients with allergic (exudative-catarrhal) diathesis .

Evidence that the drug may increase the burden on the kidneys   not, however, should not be administered to patients with severe renal failure .

In clinical studies there was no evidence of any impact of the drug on the ability to engage in activities requiring alertness and psychomotor speed, and the ability to operate a vehicle.

However, in some cases, there is a possibility of adverse side effects from psychiatric and nervous system, which in turn can temporarily disrupt the ability to drive and use machines.

The preparation of the final containers should be dialed immediately prior to injection infusion of ooze. It is allowed only one-time set of solution from ampoule or vial.

When the sludge or impurities in solution, and in the case of changing the color of the solution, its use is forbidden. Under normal circumstances, the color of amber liquid.

Analogs Cere

Match code ATC 4th level:

• Pantokaltsin
• Noben
• Cortexin
• Omaron
• Pantogam
• Pantogam Active
• Tiotsetam
• Noopept
• Kogitum
• Encephabol
• Tserakson
• Pikamilon
• Phenotropil
• Nootropil
• Vinpocetine
• Aminalon
• Fezam
• Pyracetam
• Cavinton
• Semaks

Analogs in Cere ampoules - a drug Amilonosar . Bravinton . Vinpocetine . Cavinton . Cortexin . Pyracetam . Lutset . Nootropil . Piracetam Bufus . Piracetam-Vial . Pikamilon . Tserakson . Tserebrolizat . Eskotropil . Vinpotropil . Tselleks . Tiotsetam .

In the drug also has analogues in tablets: Amilonosar . Lucidril . Vero Vinpocetine . Vinpotropil . Vinpocetine . Vintsetin . Ginkgo Biloba . Glycine . Idebenone . Gopantam . Cavinton . Calcium gopantenat . Ginkoum . Karnitsetin . Kombitropil . Lutset . Memotropil . Neyromet . Noben . Nooke . Noopept . Nootropil . Pantogam . Pikamilon . Pikogam . Piratsezin . Omaron . Pyracetam . Piriditol . Telektol . Pantokaltsin . Fezam . Phenotropil . Encephabol . Korsavin . Tselestab . Karniteps .

Cheaper analogs Cere - Tserebrolizat . Glycine . Nootropil . Tsinnazarin . Instenon .

For children

In pediatric practice Cere   apply where there is reasonable evidence.

During pregnancy (and lactation)

Conducted animal studies found no toxic effect of the drug on the reproductive system. However, data on how Cere may affect human reproduction, to date there.

In this regard it is administered to pregnant women only in those cases where there is no alternative therapy with Cerebrolysin. If necessary, the course of treatment during lactation, it is necessary to decide the issue of termination of breastfeeding.

Reviews cerebrolysin

As is the case with any other drug, reviews of physicians and patients about cerebrolysin can meet the most different. Moreover, many foreign experts believe its expensive pacifier with unproven efficacy. In addition, our doctors prescribe medication is quite common, and patients - if you believe the reviews left - often remain satisfied with the results of treatment.

For children injections are effective in the need to eliminate the effects of birth trauma When perinatal pathology central NA To reduce tension NA . In addition, the drug stimulates brain development and speech in children , Which was delivered diagnosis of "speech delay" .

However, many mothers say that the effectiveness of the medication depends on the correct selection of the dose and duration of treatment. Some believe that Cere works well in high doses or in combination with a complex physiotherapy activities.

According to parents whose children were treated with a drug, especially a pronounced progress in children can occur if the therapy was initiated about one year.

A number of negative reviews about cerebrolysin for children due to the fact that the injections quite painful, pricey and have contraindications.

Reviews adults about the drug rather contradictory. In forums where people discuss certain medicines, left a lot of positive feedback about cerebrolysin as on effective and proven means.

Some patients say they have not seen the desired effect. However, the instruction to cerebrolysin warns that the greatest clinical efficacy observed after not one but several courses of treatment.

Price Cere

Price vials of Cerebrolysin in Ukraine

The cost of 1 ml ampoules №10 - 200 UAH, buy 5 ml ampoules №5 can be around 330 USD. The vials of 10 ml №5 in Ukrainian pharmacies cost an average of 540 UAH.

Price Cere in Russia

Prices for injections Cere on the Russian pharmaceutical market of the following:

• 1 ml ampoules №10 - 660 rubles;
• 2 ml ampoules №10 - 910 rubles;
• 5 ml ampoules №5 - 970 rubles;
• 10 ml ampoules №10 - 1350 rubles.

Search price Cere tablets does not make sense, because the drug is produced exclusively in the form of a solution.

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