Description overdue on 05/29/2014
- Latin name: Nifuroxazide
- ATC code: A07AX03
- Active substance: Nifuroxazide (Nifuroxazide)
- Manufacturer: Gedeon Richter Romania, S.A. (Romania); Warsaw FZ Ternopharm of (Poland); Jurabek Laboratories Ltd (Uzbekistan)
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions on nifuroxazide
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- For children
- Newborns
- With alcohol
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
One tablet Nifuroxazide It contains the active substance: nifuroxazide - 100 mg (Richter nifuroxazide in tablet form, has an identical composition).
Excipients: gelatin, starch, talc, magnesium stearate, silica colloidal anhydrous .
The composition of the shell: titanium dioxide, polyethylene glycol, hydroxypropylmethyl cellulose , Quinoline yellow dye, talc .
In 100 grams of suspension Nifuroxazide Richter It contains the active substance: nifuroxazide - 4 grams.
Excipients: sodium hydroxide, sucrose, carboxy polymethylene, citric acid monohydrate, methyl parahydroxybenzoate, antifoaming emulsion , Banana flavor, purified water.
Product form
Tablets yellow, biconcave, round and smooth, without any damage or stains are coated shell. 24 pieces in a blister. 1 blister in a cardboard box.
The suspension (syrup, as it is sometimes called) of a yellow color, with a sweet taste and smell of banana. Available in bottles of 90 ml (with measuring spoon); 1 bottle in a cardboard package.
Pharmacological action
The drug has bactericidal and antibakterialnoym action.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics
The drug has antibacterial activity and for the treatment of infectious diseases of the digestive tract. Inhibits the activity of enzymes dehydrogenases and inhibits production of the protein in the cells of bacteria. It weakens the synthesis of toxins by microorganisms.
Affects Gram-positive microorganisms : Staphylococcus spp. ; Gram-negative enterobacteria : Salmonella spp., Klebsiella spp., Escherichia coli, Enterobacter spp., Citrobacter spp., Shigella spp., Proteus spp., Yersinia spp.
No effect on the normal flora of the gastrointestinal tract, without provoking dysbiosis . It is not conducive to the emergence of resistant strains.
The drug has no systemic effects on the body and does not alter blood parameters.
Pharmacokinetics
After taking the drug is not absorbed in the intestine, creating a significant concentration of the active substance in the digestive tract, and soon enough exhibits therapeutic effect. Excreted in the feces.
Indications
- Diarrhea (chronic and acute), caused by Gram-positive ( streptococci and staphylococci ) And some Gram ( Shigella, Escherichia coli, Klebsiella, Salmonella ) Bacteria.
- Diarrhea after Antibiotic Changes the normal bacterial flora of the colon.
- Diarrhea at appendicitis , Food poisoning, autoimmune chronic gastritis .
- Toxic diarrhea (pathogens - Gram-negative bacteria ( Salmonella, Klebsiella, Shigella, Escherichia coli ) In children aged 2 months.
Contraindications
- Allergies to the drug or any of its components.
- Age up to 2 months.
Side effects
Rarely - nausea, stomach pain.
Individual sensitivity to the drug: skin rash, shortness of breath, itching (required drug discontinuation and symptomatic treatment).
Instructions on nifuroxazide
Instructions for use Nifuroxazide (tablets) and instruction on suspension Nifuroxazide Richter (syrup) They point out that the drug is used inside the mouth.
Receive Mode suspension : For children from 2 to 6 months, the recommended dose - 2, 5-5 ml twice a day, from 6 months to 6 years - 5 ml three times a day (8 hours). Children from 6 years and adults - 5 ml every 6 hours.
Pills Nifuroxazide recommended for adults and children from 6 years to 2 tablets four times a day for 6 days.
Overdose
Overdose cases are not fixed.
Cooperation
Do not use the drug at the same time sorbents and an alcohol.
Terms of sale
In Ukraine, drug prescription in Russia - without a prescription.
Storage conditions
Keep away from children. Store at temperatures up to 25 degrees, in a dark place.
Shelf life
Two years.
Cautions
In the case of symptoms of dehydration is necessary to conduct rehydration therapy in addition to standard drug therapy.
Analogs nifuroxazide
Ersefuril
Stopdiar
Entoban
Known analogues of the drug: Enterofuril (Bosnia and Herzegovina), Nifurozid-Health (Ukraine) Lekor (Ukraine) Ersefuril (France).
For children
Note allows for the possibility of using the syrup for children between the ages of 2 months. Suspension for children from 2 to 6 months of 2.5-5 mL taken twice a day; 6 months and older - 5 ml three times a day.
Newborns
Prohibited use of the drug in infants up to 1 month and preterm infants.
With alcohol
At the time of treatment should abandon admission alcohol.
During pregnancy and lactation
Use with caution.
Reviews nifuroxazide
Reviews nifuroxazide show a sufficiently high therapeutic effect of the drug in the majority of cases when used as indicated. Reported side effects are rare.
Nifuroxazide - an antibiotic or not?
The drug is a derivative of nitrofuran. It belongs to the group of antimicrobials ( antibiotics ).
Is it better or nifuroxazide Enterofuril?
Nifuroxazide (nifuroxazide Richter) and Enterofuril are complete analogues, their price is approximately comparable. Reviews of preparations do not allow to give preference to any of them. However Enterofuril has a greater variety of forms-release tablets on the number in the package (№8, 16 and 30) and dosing (100 and 200 mg). Using the tablets in a dosage of 200 mg of the more convenient and can reduce the dosing frequency of the drug twice.
Price nifuroxazide
In Ukraine, the price Nifuroxazide Richter tablets (№24) will cost 53, 5 hryvnia, and the price suspension for children It will be about 81 hryvnia. In Russia, the price of the drug in the form of tablets - 330 rubles, in the form of syrup - 500 rubles.
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