Description overdue on 11/24/2014
- Latin name: Naklofen Duo
- ATC code: M01AB05
- Active substance: Diclofenac (Diclofenac)
- Manufacturer: KRKA, d.d., Slovenia
- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for Naklofena Duo (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Reviews
- Price, where to buy
Composition
As part of the funds is one capsule diclofenac sodium in two forms: enteric pellets - 25 mg + sustained action pellets at - 50 mg.
Also, the preparation contains auxiliary elements sucrose in sugar spheres, hydroxypropylcellulose, heavy magnesium carbonate, etilkrilat, talc, sodium carboxymethylcellulose, sodium hydroxide, ammonium methacrylate copolymer (type A and type B), triethyl citrate, methacrylic acid, triethyl citrate, titanium dioxide, macrogol, gelatin, dye indigo carmine (E132).
Product form
Naklofen Duo manufactured as a modified release capsules diclofenac . The capsules are opaque white, with a blue lid, the contents - white and orange pellets. The drug is sold in packs of 20 pieces.
Pharmacological action
The analgesic, antipyretic . anti-inflammatory .
Pharmacodynamics and pharmacokinetics
Active substance means - diclofenac - It has a strong analgesic, antipyretic and anti-inflammatory effect. With the ability to inhibit the synthesis of prostaglandins Responsible for specific body's response to inflammation, the drug quickly relieves pain, reduces temperature and reduces edema in the affected area.
At therapeutic doses agent does not affect the process of biosynthesis proteoglycans in cartilage.
The drug reduces inflammation, swelling, relieves pain in the rheumatism . In the case of postoperative application after, if necessary, to apply Opioids , The drug significantly reduces the patient's need for strong painkillers. With dysmenorrhea the drug can reduce the severity of blood loss and eliminate the pain.
After penetration of the drug into the body quickly and completely absorbed. Due to the presence of capsules prolonged the effect of the means of action lasts twice as long.
Repeated application Pharmacokinetics It does not change, no active ingredient koumouliruet . The tool has a high degree of binding to plasma proteins, bioavailability - 50 %.
The first passage through the liver, the active substance metabolized with the participation of R450CYP2C9 . Plasma half-life is 2 hours.
Withdrawal of the drug in an unchanged form, in the form metabolites , Bile and through the kidneys.
Individuals suffering from kidney disease, the number of metabolites with bile output is increased, but the concentration diclofenac levels remain constant.
Diclofenac It has the ability to penetrate synovial fluid and breast milk.
Indications
The medicine is prescribed for inflammatory and degenerative diseases of the musculoskeletal system (if rheumatoid arthritis . juvenile arthritis . rheumatic soft tissue lesions, osteoarthritis . tenosynovitis . ankylosing spondylitis . bursitis . synovitis . myositis ).
Also, the means used for the relief of pain in neuralgia . myalgia , After surgery, headache and migraines . proctitis . adnexitis , Toothache, various types colic .
Naklofen Duo may designate a part of an integrated treatment pharyngitis . otitis . tonsillitis at fever .
Contraindications
The drug is contraindicated in:
- at allergies on diclofenac ;
- when recovering coronary artery bypass grafting ;
- at stomach ulcer and gastric bleeding;
- liver and kidney;
- 3 trimester pregnancy during Lactation ;
- Children up to 18 years;
- at hyperkalemia ;
- heart failure (decompensation).
Caution should be exercised when abuse alcohol ; smoking ; CHD ; cerebrovascular diseases ; diabetes ; elderly patients; persons receiving long- NSAIDs ; in the first two trimesters of pregnancy; in combination with other drugs; at induced porphyria ; in the presence of bacteria Helicobacter at GI .
Side effects
Depending on the frequency of occurrence may occur following side effects:
- pain epigastric region, headache, cramps, diarrhea , Vomiting and nausea, anorexia . flatulence, dizziness . vertigo , Skin rash;
- gastritis , Diarrhea and vomiting with blood, ulcer , A strong decline BP . anaphylactic shock . bronchial asthma , Cough, hives , Jaundice, increased liver enzymes, drowsiness , Impaired vision, hearing or taste;
- stomatitis , Dry mouth, glossitis . hemorrhagic colitis . constipation . pancreatitis . paresthesia . tremor . disorientation , Memory impairment, hematuria , Swelling, proteinuria . agranulocytosis . leukopenia . eosinophilia . depression , Violation of sleep, tachycardia , Chest pain, heart failure, heart attack , Irritability, nightmares, thrombocytopenia , Anxiety;
- pneumonitis . purpura . eczema . exfoliative dermatitis . photosensitivity . itching .
Instructions for Naklofena Duo (method and dosage)
The dosage and mode of administration of the drug should be prescribed by a doctor depending on the disease and the individual patient.
The capsules are taken as a whole, without opening them, after or during meals. If pain occurs mainly in the morning or at night, it is recommended to drink the capsule before bedtime.
According to the instructions for use Naklofen Duo, the daily dosage ranges from 75 mg to 150 mg. Prolonged treatment, as a rule, 1 capsule per day.
Overdose
The most likely symptoms of overdose are: nausea, diarrhea, headache, ringing in the ears, cramps, abdominal pain, vomiting. When you receive a super-high doses - acute renal failure , Hepatotoxicity.
In overdose produce gastric lavage, give the victim Activated carbon Produce symptomatic therapy. Hemodialysis and diuresis ineffective.
Cooperation
Tools such as Alteplase . Urokinase and Streptokinase , Other antiagregatnye funds and anticoagulants when combined with the drug increases the risk of bleeding.
Effectiveness antihypertensive and sleeping pills under the influence of Naklofen Duo reduced.
Concentration digoxin, methotrexate, cyclosporine and lithium preparations in combination with diclofenac increases.
The risk of hyperkalemia in combination with means potassium-sparing diuretics significantly increased.
With combined with caution Aspirin ( acetylsalicylic acid ) Paracetamol . hypoglycemic agents . Tsefamadonom . Tsefotetanom . Plicamycin . Ceftazidime . Valproic acid .
When combined with Cyclosporine gold and drugs increases the load on the kidneys.
Antibacterials group quinolone significantly increase the risk of seizures.
Ethanol in combination with the drug increases the risk of bleeding.
Also, if you are taking Colchicine St. John's wort, or agents that block tubular secretion, be sure to tell your doctor.
Terms of sale
Prescription.
Storage conditions
Store at temperatures below 30 degrees Celsius, away from small children.
Shelf life
3 years.
Cautions
It should appoint a drug to people with diabetes and intolerance fructose .
Patients suffering asthma , Seasonal allergic rhinitis , Chronic respiratory tract infection, the likelihood of angioedema or hives It increases considerably.
In people with kidney disease, heart failure, advanced age and after serious operations should monitor renal function.
Chronic administration of the drug is necessary to periodically control blood parameters.
NSAIDs not recommended for women with infertility or planning to become pregnant soon, as a means to influence this group fertility .
Naklofen may mask the symptoms of infectious diseases.
The risk of allergic reactions including skin rash and angioedema It increases with prolonged use of tools. If these allergic reactions evident, stop taking the medication.
For elderly patients recommended minimum active and effective dosage.
Analogs
Olfen 100
Olfen-75
Neurodiclovit
Nayzilat
Fanigan
Aertal
Indomethacin
Ortofen
Voltaren
Dikloberl
Ketanov
Analogs of the drug: Diklo duo, Diklorapid, diclofenac sodium, Dikloberl Retard, Olfen, Almiral, Voltaren, Diklak, Naklofen Other preparations containing diclofenac.
Reviews Naklofene Duo
The drug has a wide range of applications, effective analgesic after taking the first two tablets. The drug is mostly good reviews. Capsules modified release means allow to drink less. Doctors recommend combine the drug with lowering the acidity of the digestive tract or the enveloping means in order to avoid negative impacts on the stomach. Some write that the drug is addictive and after its cancellation occur more severe pain. In this case, it should be remembered that Naklofen does not treat the cause of pain, but only reduces inflammation and pain.
Price Naklofen Duo
The price of the drug is 121 rubles per 20 capsules of 75 mg.
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