- Composition
- Product form
- Pharmacological action
- Pharmacodynamics and pharmacokinetics
- Indications
- Contraindications
- Side effects
- Instructions for use Elidel (method and dosage)
- Overdose
- Cooperation
- Terms of sale
- Storage conditions
- Shelf life
- Cautions
- Analogs
- Babies
- During pregnancy (and lactation)
- Reviews
- Price, where to buy
Composition
1 g of cream contains 10 mg pimecrolimus . As auxiliary component di- and monoglycerides, stearyl alcohol, sodium hydroxide, triglycerides Cetyl alcohol citric acid Sodium tsetilstearilsulfat, oleyl alcohol, propylene glycol , Benzyl alcohol and water.
Product form
Cream white for external use produced in aluminum tubes, and in volume 15, '30
Pharmacological action
Elidel Cream - hormonal or not?
It is a non-hormonal drug. The main mechanism of action - inhibition of the production and release inflammatory mediators . Cytokine mast cells and T lymphocytes . This ensures that the anti-inflammatory effect.
Pimecrolimus inhibits calcineurin (calcium dependent phosphatase), which leads to inhibition of proliferation T-lymphocyte and slow production interleukin-2 . tumor necrosis factor - α . γ - interferon and other cytokines.
The drug reduces the secondary immune response T cells in the skin, which were obtained from patients atopic dermatitis .
The active ingredient of the drug has no effect on the growth of endothelial , Keratinocytes and fibroblasts. Selective effect on the immune cells do not interfere with the function of cells of monocytic origin and Langerhans cells It does not affect the differentiation T cells What distinguishes pimecrolimus from corticosteroids .
The drug showed a high effect in reducing inflammation in systemic and local administration.
With allergic contact dermatitis cream significantly reduces the inflammation reaction of the skin under the effect of stimuli, is equal in efficacy Clobetasol - 17 - propionate and Fluticasone One of the most active corticosteroids. Thus there is no skin atrophy or changes its structure. Cream reduces inflammation in the skin, itching, reduces symptoms histopathology, thus acting selectively on the skin - demonstrates minimal penetration than glucocorticosteroids or tacrolimus .
The main advantage of Elidel is local (on the skin) selective antiinflammatory effect combined with minimal effect on the systemic immune response .
The treatment course of 6 weeks for children of different ages (ranging from three months) makes it possible to significantly reduce the signs of skin inflammation - redness, racoma , Infiltration, lichenification and itching. Application during the year to reduce the number of exacerbations, prevent the development of atrophy and improve skin hypersensitivity.
Elidel Cream is not phototoxic and causes photosensitivity .
Pharmacodynamics and pharmacokinetics
Pimecrolimus It has no systemic action and its blood concentration is so low that it can not estimate the parameters of metabolism.
Indications
Treatment eczema ( atopic dermatitis ) In adults and children from 3 months.
Contraindications
- idiosyncrasy;
- children up to 3 months;
- skin lesion at the site of acute infection of various origins (viral, bacterial, fungal).
Not recommended use:
- systemic erythroderma and Netherton syndrome at risk of increased systemic absorption of the drug;
- with a decrease in immunity, since there is no experience with this category of patients;
- on the skin with suspected malignant or dysplastic lesion.
Side effects
With the highest frequency observed local reactions in the form of burning, irritation, redness and itching of the skin; can be folliculitis (pustular infection).
Sometimes there Dermatitis , Eczema, herpes, paresthesia, molluscum contagiosum , Worsening of the disease.
Rarely - angioedema . hives , Anaphylactic reactions; intolerance alcohol Manifested in itching, rash, redness of the face.
Also, in rare cases, it may be a violation of skin pigmentation.
Instructions for use Elidel (method and dosage)
For the best possible treatment is initiated at the first sign of the disease to prevent progression.
The cream is applied to the skin with a thin layer and rub until completely absorbed. Apply the ointment two times a day until recovery. In case of preservation over 6 weeks of symptoms diagnosed atopic dermatitis It needs to be clarified.
If the treatment was discontinued, but developed symptoms again should resume application of the drug.
Instructions on Elidel recommended tool to soften the skin after cream applied, and in the case of receiving water procedures - before the cream.
The maximum daily dose is not, as its systemic effect is minimal.
In case of contact with mucous membranes or eyes should be washed with water.
For children, the drug is dosed as well as adults.
Overdose
No cases of overdose were reported.
Cooperation
Considering the low systemic absorption of the cream, the risk of interaction with other drugs for systemic use is unlikely.
Using children did not affect the effectiveness of the vaccine. Do not apply to the area of administration of the vaccine.
Elidel Ointment should not be mixed and applied together with other medicines for the local treatment.
Terms of sale
The pharmacy is sold by prescription.
Storage conditions
Keep out of the reach of children, to comply with the temperature not exceeding 25 ° C.
Shelf life
When opening the package store up to 12 months. Shelf life 2 years unopened cream.
Cautions
During treatment calcineurin inhibitors Including Elidel and, in rare cases, seen the emergence of malignant diseases ( lymphoma and skin tumors ). However, the link between drugs and these diseases has not been reliably established.
When lymphadenopathy unknown origin or suspicion of mononucleosis should stop the drug.
Influence of cream on the appearance of skin lesions associated with exposure to ultraviolet light, not installed, but should avoid exposure to the sun during treatment with Elidel.
Analogs of Elidel
Match code ATC 4th level: 
Protopic
The only analogue is Protopic .
However, one can say that glucocorticoids analogues Elidel as their use for the treatment atopic dermatitis . The most popular are: Advantan . Diprosalik . Kenalog . Deperzolon . Akriderm . Lorinden . Flukort . Tselestoderm . Apulein .
Babies
Apply to children from three months. In the younger age effect of the drug has not been studied.
During pregnancy and lactation
The efficacy and safety have not been studied. Because the drug has a very low degree of absorbability, probable risk is negligible.
Nursing women should not put the cream on the breasts.
Comments about Elidel
Major reviews Elidel can be found on the forums of young mothers, as recently in young children diathesis It has become a very common disease, and ointment is often used for infants. Elidel cream reviews suggest that it can quickly go moist crusts on the cheeks, the rash can be easily removed. For newborn medicine is not used up to 3 months because monitoring efficacy and safety have not been carried out.
Many mothers find effective substitute cream ointment with hormones at dermatitis As well as the use of hormones many parents of children is alarming, and they fear that there may be side effects. A disadvantage of some called addictive, and a high price, which is compensated by safety and effect.
Reviews of doctors indicate that Elidel is widely used for children. Doctors point out as an advantage the possibility of long-term use, that distinguishes the ointment from hormonal methods. Outs referred to the high cost of the drug and that it strongly dries the skin. But it can be corrected using the mitigation of ointments and creams. Also, according to the doctors, it is necessary to remember that Elidel can not get rid of allergies Main reason atopic dermatitis . This is a problem of the whole organism and the treatment requires a comprehensive approach, excluding allergens .
Price Elidel where to buy
In Russia, the price of Elidel cream is from 936 rubles. to 990 rubles. 15-gram tube.
In Moscow, the cost of the drug is on average 967 rubles.
Price ointments Elidel in Kiev (Ukraine), about 246 USD. for '15
Buy in Minsk medicine can be for 230 500 rubles.
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