Tizalud

Description overdue on 11/27/2014

• Latin name: Tisalud
• ATC code: M03BX02
• Active substance: Tizanidine (Tizanidine)
• Manufacturer: OAO Veropharm (Russia)

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• Composition
• Product form
• Pharmacological action
• Pharmacodynamics and pharmacokinetics
• Indications
• Contraindications
• Side effects
• Tablets Tizalud, instructions for use
• Overdose
• Cooperation
• Terms of sale
• Storage conditions
• Shelf life
• Cautions
• Analogs
• Babies
• With alcohol
• During pregnancy (and lactation)
• Reviews
• Price, where to buy

Composition

One tablet contains 2 mg or 4 mg Tizanidine   - The active ingredient.

Additional ingredients: sodium carboxymethyl starch, lactose anhydrous, magnesium stearate, microcrystalline cellulose.

Product form

Tizalud drug comes in the form of tablets of 2 and 4 mg of 30 pieces in the same package.

Pharmacological action

Muscle relaxant, the central action.

Pharmacodynamics and pharmacokinetics

Tizalud is relaxant exhibiting the central action.

Effects tizanidine on presynaptic α2-adrenergic receptors   causes inhibition of the allocation process spinal   intermediate neurons   excitatory amino acids Which leads to inhibition of the polysynaptic pulse propagation in spinal cord . Through this mechanism of action is reduced muscle tone . In parallel with the miorelaksiruyuschim effect tizanidine It shows moderate severity analgesic   action.

Tablets Tizaluda effective in acute painful muscle spasms , and chronic spasms cerebral and spinal etiology . The drug reduces the clonic seizures   and spasticity muscle, resulting in decreased resistance to passive movements and increases the possibility of action.

Indications

Muscle spasms   pathologies of the spine, accompanied pain , including hemiplegia . spondylosis . osteochondrosis . syringomyelia , Lumbar and cervical syndrome.

Postoperative period after surgical interventions for hip osteoarthritis   joint and intervertebral hernia .

Pain syndrome   and spasticity muscle provoked neurological diseases Including chronic myelopathy . multiple sclerosis .   cerebral palsy , Degenerative changes in the spinal cord, stroke , Violations Brain circulation , Head injuries, convulsions central genesis.

Contraindications

• hypersensitivity tizanidine or other components of the tablet ingredients Tizalud;
• severe liver disease;
• periods breast-feeding   and pregnancy ;
• age up to 18 years;
• receiving concurrent therapy with Ciprofloxacin . Fluvoxamine and other strong isoenzyme CYP1A2 inhibitors .

Carefully:

• age over 65 years;
• renal failure ;
• bradycardia ;
• hypotension ;
• application oral contraceptives .

Side effects

CNS:

• dizziness ;
• drowsiness ;
• hallucinations ;
• sleep disorders;
• insomnia .

Cardiovascular system:

• lowering blood pressure;
• bradycardia .

Digestive system:

• dryness of the mouth;
• dyspepsia ;
• nausea ;
• hepatitis ;
• increased activity of "liver" transaminases;
• hepatic failure .

Musculoskeletal system:

• muscular weakness .

Others:

• hypercreatininemia ;
• fatigue.

Abrupt withdrawal after the combination Tizaluda reception antihypertensive drugs   and long-term treatment and / or large doses, can cause increased blood pressure . tachycardia And, in some cases, an acute poor circulation of the brain .

Tablets Tizalud, instructions for use

The tablets of the drug taken by mouth (orally), drinking water, regardless of meals.

Instructions for use when Tizaluda neurological pathologies Causing spastic painful muscle contraction It recommends to begin treatment with a daily dose of 6 mg taken in three steps. Each subsequent 3-7 days, depending on the nature pain and spasm , Increasing the dose of 2-4 mg. The maximum therapeutic effect is observed when taking a daily dose of 12-24 mg. The dose of 36 mg is the maximum daily dose.

For relief pain spasm   skeletal muscle   administered 3 times a day daily intake of 2-4 mg Tizaluda. In particularly difficult situations recommend additional intake of 2-4 mg per night.

Duration of Tizaluda depends on the dynamics pain and musculo-tonic   manifestations. Acute muscle aches   usually require therapy for 7-21 days. Chronic pain , Depending on the origin and severity, may require a more long-term treatment, which is determined on an individual basis and sometimes continues for up to 1 year.

Overdose

In flagrant violation of dosage regimen and higher doses Tizaluda observed: nausea Passing into vomiting , Development hypotension . drowsiness , Dizziness, corestenoma . respiratory disorders , Anxiety, whom .

Recommends the immediate   gastric lavage . bowel clean   via enema reception Activated Carbon Holding forced diuresis   and further symptomatic therapy.

Cooperation

Not allowed simultaneous reception with Tizaluda Ciprofloxacin . Fluvoxamine and other strong inhibitors of CYP1A2 isoenzyme , including Amiodarone . Propafenone . Mexiletine . Cimetidine . Enoxacin . Norfloxacin . Pefloksatsina . Rofecoxib . Ticlopidine   and oral contraceptives .

Preparations antihypertensive   actions increase the risk of bradycardia and lowering blood pressure .

Sedatives   and ethanol May strengthen sedative effects of tizanidine .

Terms of sale

Tablets Tizaluda dispensed from pharmacies in the presence of a doctor's prescription.

Storage conditions

Tizalud drug store in a dark, dry place at ambient temperatures up to 25 ° C.

Shelf life

The tablets in the original packaging, can be stored for 24 months.

Cautions

During the long-term treatment Tizaludom should check your liver at least the 1st time in a month, especially during the first 4 months of therapy.

Because of the threat of " withdrawal ", In case of failure of therapy, the dose tizanidine reduce gradually.

If the pill is better to give up driving and transportation of precision or dangerous work.

Analogs Tizaluda

Match code ATC 4th level:

• Baklosan
• Sirdalud
• Baclofen

Similar in their effect analogues are presented Tizaluda drugs: Liorezal . Baklosan . Mydocalm . Tolperisone . Tolperil and some others.

Babies

Tizalud not be appointed until the age of 18 years.

With alcohol

Joint reception Tizaluda and alcohol is not recommended.

During pregnancy (and lactation)

Do not use this pills Tizaluda in times breast-feeding   and pregnancy .

Reviews Tizalude

In the user forums there are both positive and negative reviews about Tizalude. Tellingly, the negative reviews are often related adverse drug events that occur immediately after the first dose, and manifesting lowering blood pressure . weakness . dizziness . retardation and sleepiness . Such effects are possible while taking the drug at high doses, or the patient has no contraindications. Therefore, even if you completely trust your doctor, it is better to start therapy with receiving half or even a quarter of the recommended doses and under normal tolerability go to the full application.

Many patients are quite effective Tizaluda, noted his quick action and lack of side effects. Of course, any medication individually for each patient and if Tizalud not cause you negative reactions, it is likely to be of the effective means.

Price Tizaluda where to buy

Price Tizaluda pharmacies in Russia on average 130 rubles for 30 tablets of 2 mg and 175 rubles for 30 tablets of 4 mg.

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